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  • 2005-2009  (1)
  • 1985-1989  (2)
  • 1
    Electronic Resource
    Electronic Resource
    New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : In functional gastrointestinal (GI) disorders including functional dyspepsia (FD) and irritable bowel syndrome (IBS), there might be no small extent of contributions of psychosomatic factors. As a therapy for IBS patients, the effectiveness of antidepressants has been reported.Aim : In this study, we evaluated the efficacy of H2-receptor antagonist (famotidine) and 5-HT4 receptor agonist (mosapride citrate). In addition, the effect of antidepressants was assessed as the second-step therapy.Methods : Patients complaining upper GI symptoms were diagnosed as FD excluding organic diseases. Randomized patients received 20 mg/day of famotidine or 15 mg/day of mosapride citrate for 4 weeks and the efficacy was compared between the two groups based on a 10-point visual analogue scale. When symptoms were not relieved (score improvement 0–2 points), patients received amitriptyline (30 mg/day) or no medication for 4 weeks randomly. Patients who had depression in psychological test (SDS) were omitted.Results : As the first-step therapy, both famotidine and mosapride showed beneficial effects regardless of FD subtypes, age and gender. The efficacy of these two drugs in relieving FD symptoms was not significantly different. In patients who failed in the first-step therapy, amitriptyline showed beneficial effects.Conclusions : These findings might be clinically important in view of the efficient relief of symptoms in FD patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02473.x
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence for sequential degeneration of the neurons in the intermediate zone of the spinal cord in amyotrophic lateral sclerosis: a topographic and quantitative investigation (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 343-349 
    Details
    ISSN: 1432-0533
    Keywords: ALS ; Spinal cord ; Propriospinal neuron ; Anterior horn cell ; Quantitative study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To elucidate the degenerating mechanism of the neurons in the intermediate zone of the spinal cord in classical amyotrophic lateral sclerosis (ALS), the spinal neurons in a patient with ALS, whose muscular strength was fairly well preserved up to death, were examined quantitatively and topographically, and compared with the data of advanced ALS patients and age-matched control subjects reported previously. In advanced ALS patients, anterior horn cells completely disappeared and the medium-sized (nuclear area; 71–150 μm2) and large (nuclear area; greater than 151 μm2) neurons in the intermediate zone were severely reduced. In the present case, however, the loss of anterior horn cells was severe but the degree was not equal to that of advanced ALS patients, and the neurons in the intermediate zone were quite well preserved. The finding indicates that the primary degeneration may occur in the anterior horn cells and the neurons in the intermediae zone degenerate sequentially in the spinal gray matter in ALS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687368
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Nafion-like thin film plasma-polymerized from perfluorobenzene/SO2 mixture (1989)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 27 (1989), S. 3495-3501 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Plasma polymerization of perfluorobenzene/sulfur dioxide (PFB/SO2) mixture was investigated by elemental analysis, infrared spectroscopy, and XPS. Plasma polymer films like Nafion were obtained from the plasma polymerization of PFB/SO2 mixture. The plasma polymerization deposited fluoropolymers with sulfur moieties including sulfonate and sulfonic acid groups. The elemental composition, F/C, and S/C atomic ratio of the formed plasma polymers were 0.65-0.67 and 0.24-0.27, respectively, which were independent of the starting mixture composition. The polymers showed cation-exchange ability of which the capacity was 0.49 meq/g polymer, and initiated the polymerization of pyrrole.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1989.080271026
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