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  • 2005-2009
  • 1975-1979  (3)
  • 1935-1939
  • Glomerular filtration rate  (2)
  • Chronic persistent and aggressive hepatitis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 365 (1976), S. 81-87 
    ISSN: 1432-2013
    Keywords: Renal failure ; Micropuncture ; Diuretics ; Glomerular filtration rate ; Effective filtration pressure ; Renal blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The renal effects of furosemide in acute renal failure of the rat were studied using clearance and micropuncture techniques. Acute renal failure was induced by an intramuscular injection of 50% glycerol (10 ml/kg). Functional impairement of the glycerol treated animals consisted of a decrease in urinary sodium excretion, renal blood flow, total kidney GFR and effective filtration pressure of superficial nephrons. Effective filtration pressure was calculated from proximal free flow and stop flow pressure measurements. In contrast to control animals furosemide did not increase urine volume during acute renal failure due to a marked fall in GFR. Renal blood flow, as measured by an electromagnetic flowmeter, also decreased after furosemide in glycerol treated rats and increased in control animals. Furosemide reduced effective filtration pressure during acute renal failure to almost zero, whereas in control animals effective filtration pressure virtually remained constant.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 54 (1976), S. 137-140 
    ISSN: 1432-1440
    Keywords: Chronic persistent and aggressive hepatitis ; Aggressive Emperipolesis ; Lymphocyte cytotoxicity ; Cellular immune reaction ; Piecemeal necrosis ; Chronische persistierende und aggressive Hepatitis ; Aggressive Emperipolese ; Lymphozyten-Cytotoxizität ; Zelluläre Immunreaktion ; Mottenfraßnekrose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In Biopsiepräparaten von chronischen Hepatitiden wurde die Penetration und Zerstörung von Hepatocyten durch Lymphocyten (aggressive emperipolese) beschrieben und quantitativ ermittelt. Bei den untersuchten 48 Fällen von chronisch-persistierender Hepatitis spielte die aggressive Emperipolese nur eine untergeordnete Rolle und fehlte in vielen Fällen gänzlich. Demgegenüber ist sie bei den 36 untersuchten Fällen von chronischaggressiver Hepatitis stets deutlich, mitunter sogar in erheblichem Ausmaß vorhanden. Die aggressive Emperipolese ist — neben den Mottenfraßnekrosen — ein morphologisches, im Leberstanzzylinder lichtmikroskopisch nachweisbares Substrat für den Prozeß der „self-perpetuation“ des chronisch-entzündlichen Geschehens und ein weiteres Kriterium für die Abgrenzung der beiden Haupttypen der chronischen Hepatitis.
    Notes: Summary The penetration and destruction of hepatocytes by lymphocytes (aggressive emperipolesis) has been described and examined quantitatively in biopsy specimens of chronic hepatitis. In 48 cases of chronic persistent hepatitis, the aggressive emperipolesis was rare and, obviously, not of great importance; sometimes there was no emperipolesis at all. In 36 cases of chronic aggressive hepatitis, however, emperipolesis was always evident, usually even to a very high extent. The aggressive emperipolesis — as well as the piecemeal necrosis — is a significant phenomenon which can be seen in the light microscope in liver biopsies and gives evidence to the fact that this chronic inflammatory process is a progressive one; furthermore, it is an additional criterion to differentiate the two main types of chronic hepatitis.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 301 (1977), S. 139-143 
    ISSN: 1432-1912
    Keywords: Renal function ; Renal blood flow ; Glomerular filtration rate ; Urine volume ; Urinary sodium excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of the competitive angiotensin II antagonist saralasin (1-sarcosine-8-alanine-5-isoleucine-angiotensin II) on renal function in healthy rats and in rats with myohemoglobinuric acute renal failure were studied. Acute renal failure was induced by an intramuscular injection of 50% glycerol (10 ml ·kg−1). Functional impairment of the glycerol treated animals consisted in a decrease of renal blood flow (electromagnetic flowmeter) and GFR and in an increase of urine volume and arterial blood pressure. In healthy rats saralasin (6 μg·kg−1·min−1 i.v.) had no renal effects by itself but antagonized the angiotensin II (200 ng·kg−1·min i.v.) induced fall of renal blood flow and GFR and the increase of arterial blood pressure. Given to glycerol treated animals saralasin did not induce any change of arterial blood pressure, renal blood flow, GFR or the urinary excretion of fluid and sodium.
    Type of Medium: Electronic Resource
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