ISSN:
1432-0428
Keywords:
Hyperinsulinaemia
;
rat adipocytes
;
glucose oxidation
;
glucose transport
;
lipogenesis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Glucose oxidation and lipogenesis were studied in isolated adipocytes from control and nonobese, experimentally hyperinsulinaemic rats. In cells from the hyperinsulinaemic animals oxidation of either [1-14C]- or [6-14C] glucose was increased in the presence or absence of insulin, at substrate concentrations from 0.1 to 20 mmol/l. Glucose incorporation into total triglycerides and fatty acids was also increased. These enhanced rates of glucose metabolism were due to increased activity of the glucose transport system in addition to increased activity of intracellular glucose metabolism. Therefore, these data indicate that insulin can influence long term glucose homoeostasis by augmenting the overall cellular capacity for glucose metabolism at several loci.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01222211
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