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  • 2005-2009  (1)
  • 1975-1979  (2)
  • 1
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Pregnancy frequently interferes with the course of bronchial asthma, and asthmatic pregnant women experience less successful pregnancies. T lymphocytes synthesizing IL-4 or IFN-γ are important in allergic mechanisms of the airways as well as in materno-fetal immunity.Objective We hypothesized that pregnancy (a T helper-2 polarized state) of asthmatics will enhance the number of circulating T2 lymphocytes, but decrease the subset-producing IFN-γ (T1 lymphocytes) and thereby cause a culminating T2 dominance with possible clinical consequences.Methods IL-4- or IFN-γ-producing T lymphocytes were determined by flow cytometry in healthy (n=8) and asthmatic (n=13) non-pregnant women and healthy (n=18) and asthmatic (n=48) pregnant women of similar chronological and gestational (2nd–3rd trimester) age and asthma severity (Global Initiative for Asthma II–III).Results In the blood of non-pregnant women – healthy or asthmatic – the numbers of IL-4- and IFN-γ+ T cells were very low (〈10/μL blood). In contrast, in asthmatic pregnant women, the cell counts were 182±27 and 39±6 for IFN-γ+ and IL-4+ T cells/μL blood, respectively (both P〈0.05 vs. respective control values of non-pregnant asthmatics). Within the asthmatic pregnant group, significant negative correlations were revealed between the numbers of IFN-γ+ or IL-4+ T cells and maternal peak expiratory flow as well as birth weight of newborns (both P〈0.05).Conclusion These data show a previously unknown immunological interference between asthma and pregnancy. The culminating proliferation of IFN-γ+ and IL-4+ T lymphocytes may potentially impair maternal airway symptoms as well as fetal development.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 35 (1979), S. 413-414 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Mild acidic treatment increases the rheumatoid factor titre of some sera and synovial fluids (SF) in rheumatoid arthritis (RA), juvenile RA (JRA) and most frequently in rheumatoid vasculitis. This unmasking of ‘hidden’ RF in serum and SF samples correlated with the RF-immune complexes (RF-IC) and complexed C4 present in the 3% polyethylene glycol (PEG) precipitates, indicating that by means of ‘hidden’ RF measurements RF-ICs are possibly detected. This method seems to provide a diagnostic tool for detecting RF-ICs in RA and other related diseases.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 221 (1978), S. 105-113 
    ISSN: 1434-4726
    Keywords: Tonsilläre Lymphozyten ; E-Rosetten ; EA-Rosetten ; Tonsillitis ; Alter ; Tonsillar lymphocytes ; E-rosette ; EA-rosette ; Tonsillitis ; Age
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Tonsillar E and EA rosette forming lymphocyte subpopulations were studied in 120 tonsillectomized patients. T cell ratio was usually lower in the tonsils than in the blood. EA binding cells were studied with indicator systems of human or rabbit antibody sensitized red cells, respectively. Poorly sensitized human RBCs (EArabbit) bind much better to tonsillar cells than to blood lymphocytes and so this system proved to be specially suitable to study tonsillar EA binding cells. Increase in E and EArabbit rosette forming cell frequencies were found with the age of patients. Decrease in percentage of T cells and EArabbit rosette binding cells were found with high frequency of acut tonsillitis and with clinical symptoms of chronic local inflammation. The variation of these lymphocyte subpopulations with the local tonsillar inflammatory processes suggest a considerable clinical immunological role of local T cells and of this portion of Fc receptor positive lymphocytes.
    Notes: Zusammenfassung Tonsilläre E- und EA-Rosetten bildende Lymphozytensubpopulation untersuchten die Verfasser bei 120 tonsillektomierten Patienten. Die T-Zellen-Ratio war gewöhnlich niedriger in den Tonsillen als im Blut. EA bindende Zellen wurden im Indikatorsystem der mit humanen oder Kaninchen-Antikörper sensibilisierten Erythrozyten untersucht. Schwächer sensibilisierte humane Erythrozyten (EAKaninchen) binden sich besser an Tonsillenzellen als an Blutlymphozyten. Verstärkt wurden E- und EAKaninchen-Rosetten bildende Zellen, frequentiert mit zunehmendem Alter der Patienten gefunden. Prozentuale Herabsetzung der T-Zellen und EAKaninchen-Rosetten bildenden Zellen wurde bei sehr häufig auftretender akuter Tonsillitis und im Falle klinischer Symptome der chronischen lokalen Entzündung beobachtet.
    Type of Medium: Electronic Resource
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