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Renal handling of oxalate a micropuncture study in the rat (1978)

Hautmann, R. ; Osswald, H.

Springer

Naunyn-Schmiedeberg's archives of pharmacology 304 (1978), S. 277-281

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ISSN: 1432-1912

Keywords: Oxalate excretion ; Probenecid ; Micropuncture ; Microperfusion ; Rat kidney

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Clearance and micropuncture experiments were performed in rats to study the renal handling of oxalate. The 14C-oxalate to 3H-inulin clearance ratio (C ox /C in ) was 1.36±0.04 and was lowered by probenecid (200 mg/kg) to 1.11±0.03 (±S.E., n=6, P〈0.005). an attempt was made to localize the assumed secretion of oxalate in three different micropuncture protocols. In free flow micropuncture experiments single nephron clearance of oxalate was not different when obtained from proximal or distal tubular puncture sites. The fractional delivery of oxalate averaged 0.84 ±0.03 regardless of the puncture site from midproximal to late distal. This finding indicates a net outflux of oxalate in an early proximal loop since oxalate is freely ultrafilterable. In microperfusion experiments the mean recovery of oxalate ranged from 79–90%. The outflux of oxalate correlated linearly with the tubular load (r=0.95). The results suggest that no net secretion occurs in superficial nephron segments accessible for micropuncture. Since whole kidney clearances of oxalate always exceeded glomerular filtration rate, it is concluded that net addition of oxalate into the tubular fluid can occur at sites beyond the superficial late distal tubules or is due to higher delivery of oxalate by deep cortical nephrons.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00507969

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Studies for the Development of a Simulation Basis for Numerically Controlled Driving of Sheet Metal (2005)

Hoffmann, Hartmut ; Hautmann, R. ; Petry, R.

s.l. ; Stafa-Zurich, Switzerland

Advanced materials research Vol. 6-8 (May 2005), p. 517-524

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ISSN: 1662-8985

Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: The manufacturing technique of driving is one of the oldest procedures for sheet metal forming and has been used in the ancient world for the production of copper pots and vases. This technique is still utilized for niche applications but today has lost its importance. The process of driving is almost completely carried out manually and thus is only appropriate for very small quantities or in case of failure of other production processes. Since individualization of products is strongly gaining in significance, forming processes have to be found, which are independent from expensive tools and equipment. Using driving as the process of choice to form sheet metal, the grade of automation of the forming process has to be increased. Numerically controlled driving, i.e. automated positioning and handling of the work piece during the production process, will need a conclusive simulation base. This paper provides results of the analysis of sheet steel angles formed by the driving sub groups of shrinking and stretching