ISSN:
1432-1912
Keywords:
Vasodilator Agents
;
Oxygen Consumption
;
Blood Flow
;
Hindlimb
;
Sympathectomy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The influence of various vasodilating agents on the oxygen consumption was studied in the hindlimb of the cat. During the increase in flow by means of papaverine, acetylcholine, bradykinin, cobaltous chloride, isoprenaline, and phentolamine, an initial increase in the oxygen consumption for about 30 to 60 sec was observed. This phase was immediately followed by a sustained reduction in oxygen uptake below the control value although the blood flow remained increased. The diminution was greater than the initial elevation in oxygen uptake and was correlated with the increase in blood flow. An inhibition of the sympathetic constrictor nerve activity did not influence the biphasic changes in oxygen consumption due to the vasodilating agents. The blockade of the sympathetic vasoconstrictor tone led itself to a vasodilation, which was accompanied by an elevation of oxygen uptake during the whole period of flow increase. It is suggested that a shift in the pattern of flow within the extremity is responsible for these changes in oxygen consumption following the administration of the vasodilating agents tested here.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00500055
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