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  • 2005-2009  (2)
  • 1970-1974  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 68 (2006), S. 97-121 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Although there have been important advances in diagnostic modalities and therapeutic strategies for congenital heart defects (CHD), these malformations still lead to significant morbidity and mortality in the human population. Over the past 10 years, characterization of the genetic causes of CHD has begun to elucidate some of the molecular causes of these defects. Linkage analysis and candidate-gene approaches have been used to identify gene mutations that are associated with both familial and sporadic cases of CHD. Complementation of the human studies with developmental studies in mouse models provides information for the roles of these genes in normal development as well as indications for disease pathogenesis. Biochemical analysis of these gene mutations has provided further insight into the molecular effects of these genetic mutations. Here we review genetic, developmental, and biochemical studies of six cardiac transcription factors that have been identified as genetic causes for CHD in humans.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Phytopathology 43 (2005), S. 141-169 
    ISSN: 0066-4286
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Biology
    Notes: Economic, environmental, and technological influences complicate the task of achieving disease-free products in the ornamentals industry. Integrated pest management (IPM) is a cornerstone of floriculture and nursery crop production: strategies include sanitation, clean stock, host resistance, and control through biological, cultural, environmental, chemical, and regulatory means. Sanitation measures and cultural controls must keep pace with new production technologies. Clean stock programs are used for many crops that are propagated vegetatively. Breeding, selection, and biotechnology provide crops resistant to pathogens. Offshore production for economic competitiveness can introduce pathogens that make regulatory programs necessary. New biocontrol and chemical products continue to improve control while meeting the requirement for minimal environmental impact. Continual introduction of new crops and new production technologies creates new opportunities for pathogens to exploit, such that new disease management tactics must be discovered and old ones rediscovered to achieve optimum health management for ornamentals.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    The @international journal of nautical archaeology 2 (1973), S. 0 
    ISSN: 1095-9270
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Archaeology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The structure and polysaccharide constitution of the jelly capsule of the egg of Rana pipiens is described. Microscopic examination of the jelly capsule revealed the presence of five discrete jelly layers that differed clearly in their response to selected cytochemical tests. These layers were classified as M1-through M5 from the inner to the outermost layer. A sixth layer occasionally could be observed between M3 and M4.All layers contain neutral mucopolysaccharides. In addition layers M1 and M3 contain sulphated mucopolysaccharides, M2 and M4 contain non-sulphated acid mucopolysaccharides, and layer M5 contains both sulphated and non-sulphated acid mucopolysaccharides. M2 may also contain a small quantity of sulphated mucopolysaccharides. The layer that occasionally appears between M3 and M4 is probably an area in which free acidic groups are in higher concentration than in adjacent areas rather than being a discrete jelly layer. Neither hyaluronic acid nor sialic acid was localized by the methods employed.The possible significance of some of these constituents is discussed.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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