ZIB

1

Digitale Medien

Rofecoxib as adjunctive therapy for haemophilic arthropathy (2005)

Rattray, B. ; Nugent, D. J. ; Young, G.

Oxford, UK : Blackwell Science Ltd

Haemophilia 11 (2005), S. 0

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ISSN: 1365-2516

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Summary. Joint haemorrhage and subsequent haemophilic arthropathy are significant complications in haemophilia. The pathophysiology involves inflammation and angiogenesis. Cyclooxygenase-2 (COX-2) inhibitors are anti-inflammatory agents, which have potent anti-inflammatory, anti-angiogenic and analgesic properties yet do not affect platelet function in the manner of traditional non-steroidal anti-inflammatory drugs. These properties make such agents potentially useful as adjunctive therapy in haemophilia. There is only one prior report describing rofecoxib treatment in a single haemophilia patient. Our objectives were to determine the safety and efficacy of rofecoxib in treating acute haemarthrosis, chronic synovitis, target joints and pain. We conducted a retrospective medical record review of patients treated with rofecoxib for acute haemarthrosis, chronic synovitis, target joint or pain. The safety and efficacy of rofecoxib treatment were determined based on subjective patient reports and physical examinations during follow-up clinic visits. A total of 28 patients between 3 and 37 years of age were treated for a total of 42 courses of rofecoxib treatment. All courses were evaluated for safety and 31 for efficacy. Rofecoxib was used for eight acute haemarthrosis, four target joints, seven cases of synovitis and 12 episodes of pain. Efficacy was demonstrated particularly for chronic synovitis and pain and no serious adverse events occurred. This is the largest study to date evaluating COX-2 inhibitors as adjunctive therapy in haemophilia and suggests that these agents may be an important adjunctive therapy in the management of haemophilia.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1365-2516.2005.01087.x

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2

Digitale Medien

Prophylactic recombinant factor VIIa in haemophilia patients with inhibitors (2005)

Young, G. ; McDaniel, M. ; Nugent, D. J.

Oxford, UK : Blackwell Science Ltd

Haemophilia 11 (2005), S. 0

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ISSN: 1365-2516

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Summary. Prevention of bleeding, especially into joints, with prophylactic factor infusions is the most effective treatment for severe haemophilia patients. Approximately 15–30% of patients with factor VIII deficiency and 3–5% of patients with factor IX deficiency develop neutralizing antibodies (inhibitors) to factor precluding their use. Such patients often have significant bleeding complications including life- and limb-threatening bleeds and severe joint disease. Prophylaxis for such patients is not generally considered because of the fact that the standard (bypassing) agents for such patients are not as effective as natural factor replacement, because of concerns for thrombotic complications and also because of the very high cost of bypassing agents. We treated two patients with high titre inhibitors with prophylactic recombinant factor VIIa (rFVIIa). The first patient was treated as a result of development of a target joint and to reduce the use of agents that can lead to anamnesis of his inhibitor. The second patient had multiple severe bleeds and was hospitalized 20% of the time over a 2-year period. He had a very poor quality of life. Both patients had shown good responses previously to rFVIIa for treatment of bleeds. Both patients had an outstanding response to prophylaxis albeit at a very high cost. Prophylaxis with rFVIIa can be an effective approach in select inhibitor patients with severe complications related to bleeding.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1365-2516.2005.01096.x

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3

Unbekannt

The Human Condition: Browning's "Cleon" (1969)

Lee, Young G.

Morgantown, W.Va. : Periodicals Archive Online (PAO)

Victorian poetry. 7:1 (1969) 56

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ISSN: 0042-5206

Thema: Anglistik, Amerikanistik

Notizen: BRIEF ARTICLES AND NOTES

URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:d580-1969-007-01-000006

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4

Digitale Medien

Facilitation of Peptide Synthesis by the Use of 4-Picolyl Esters: Synthesis of Val 5 –Angiotensin II (1969)

GARNER, R. ; YOUNG, G. T.

[s.l.] : Nature Publishing Group

Nature 222 (1969), S. 177-178

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Fig. 1. Scheme of synthesis of protected VaP-angiotensin II. All the ammo-acids have the L-con- figuration. Z, Benzyloxycarbonyl; Boc, f-butoxycarbonyl; Bzl, benzyl; Pic, 4-picolyl; OCP? 2,4,5-trichlorophenoxy. Stage la is the first coupling reaction, stage 16 is the removal of the amino-protecting ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/222177a0

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5

Digitale Medien

Novel Facilitation of Peptide Synthesis (1968)

CAMBLE, R. ; GARNER, R. ; YOUNG, G. T.

[s.l.] : Nature Publishing Group

Nature 217 (1968), S. 247-248

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] We are examining a fundamentally different procedure in which reactions are carried out in solution and the protected peptide is then adsorbed on an ion-exchanger while the excess of acylating agent and the co -products are washed away. For this purpose, a weakly basic group has been incorporated ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/217247b0

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6

Digitale Medien

Oscillating reactions in open systems (1969)

Gross, Benjamin ; Kim, Young G.

Springer

Bulletin of mathematical biology 31 (1969), S. 441-452

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ISSN: 1522-9602

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Mathematik

Notizen: Abstract The probable existence of oscillating chemical reactions has been attracting some interest in recent years for their possible role in explaining certain biological phenomena. Perhaps the simplest model of oscillating reactions is that of Lotka (1910), which consists of a chain of autocatalytic reactions. Two “reactor systems” in which such a chain of reactions could take place are considered in this work and are called homogeneous and compartmental models, respectively. The differential equations governing the temporal behavior of the reacting species are solved on an analog computer, and the conditions under which sustained oscillations occur are obtained and discussed. Comparisons of the solution obtained in the two models are discussed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02476629

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7

Digitale Medien

Minimizing the natural fuel requirement for nuclear reactor power systems: A nonstandard optimal control problem (1968)

Nelson, P. ; Young, G.

Springer

Journal of optimization theory and applications 2 (1968), S. 138-154

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ISSN: 1573-2878

Quelle: Springer Online Journal Archives 1860-2000

Thema: Mathematik

Notizen: Abstract A class of model problems in nuclear reactor economics is defined and shown to be equivalent to a linear optimal control problem to which present versions of the maximum principle apparently cannot be applied. It is shown that the search for an optimal control can be restricted tocontrols of maximum fuel utilization (Comfu), and that theComfu's are in a one-to-one correspondence with the functions which satisfy certain inequalities and are solutions of a nonlinear Volterra integral equation containing the value of the cost functional as a parameter. In the general case, one can establish an iterative procedure, involving solution of the integral equation at each iteration, for approximating the optimalComfu. For some important special cases, a point on the solution corresponding to the optimalComfu is knowna priori, and thus the optimalComfu can be obtained by solving the integral equation only once. Some possible generalizations of the original economic model are also discussed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00929589

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