ISSN:
1013-9826
Quelle:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Thema:
Maschinenbau
Notizen:
Titanium has limitations in its clinical performance in dental and orthopaedicapplications. Over the last decade, numerous implant surface modifications have been developedand are currently used with the aim of enhancing bone integration. In the present study, we haveexperimented a bioactive titanium prepared by a simple chemical and moderate heat treatment thatleads to the formation of a bone-like apatite layer on its surface in simulated body fluids. We havedused foetal rat calvaria cell cultures to investigate bone nodule formation on bioactive titanium.Scanning electron microscopy (SEM) showed that cells attached and spread on the bioactivesurfaces. After 22 days of culture, bone nodules were detected on the material surface. Furthermore,the mineralized bone nodules remained attached to the bioactive titanium surface but not tountreated titanium. SEM observations and EDX microanalysis of sectioned squares showed thatbone-like tissue directly bonded to bioactive titanium, but not pure titanium. These results indicatedthe importance of the implant surface composition in supporting differentiation of osteogenic cellsand the subsequent apposition of bone matrix allowing a strong bond to bone. Furthermore, thesefindings may provide promising strategies for the development of biologically active implants
Materialart:
Digitale Medien
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.939.pdf
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