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  • 2005-2009  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Determinants of nitric oxide steady-state levels during anaerobic respiration by Neisseria gonorrhoeae (2005)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 58 (2005), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Nitric oxide (NO) is an important host defence molecule that varies its immune stimulatory effects depending on the concentrations at which it is produced, with low concentrations (〈 1 µM) promoting an anti-inflammatory host response while higher concentrations (〉1 µM) lead to inflammatory responses. Neisseria gonorrhoeae grows anaerobically by anaerobic respiration using nitrite reductase (Nir) to convert nitrite to NO and nitric oxide reductase (Nor) to convert NO to nitrous oxide. As N. gonorrhoeae can both produce and degrade NO, we have begun a study of NO metabolism in this bacterium to understand how gonococcal manipulation of NO concentration may influence the inflammatory response during infection. N. gonorrhoeae has an apparent Nir Km of 33 µM nitrite and an apparent Nor Km of 1.2 µM NO. The maximum specific activities for Nir and Nor were 135 nmoles nitrite reduced per minute per OD600 (pH 6.7) and 270 nmoles NO reduced per minute per OD600 (pH 7.5) respectively. N. gonorrhoeae established a steady-state concentration of NO after nitrite addition that was dependent on the nitrite concentration until saturation at 1 mM nitrite. The NO steady-state level decreased as pH increased, and the ratio of activities of Nir and Nor correlated to the NO steady-state level. When the NO donor DETA/NO was used to simulate host NO production, N. gonorrhoeae also established a NO steady-state level. The concentration of NO at steady state was found to be a function of the concentration of NO generated by DETA/NO, with N. gonorrhoeae reducing the NO from proinflammatory (〉1 µM) to anti-inflammatory (∼100 nM) concentrations. The implications of the ability of N. gonorrhoeae to maintain an anti-inflammatory NO concentration is discussed in relation to asymptomatic infection in women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.2005.04807.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Finding the balance: Living with memory loss (2005)
    Melbourne, Australia : Blackwell Science Pty
    International journal of nursing practice 11 (2005), S. 0 
    Details
    ISSN: 1440-172X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Since the late 1980s, it has been increasingly recognized that the experiences of people with dementia have been omitted from research in the area of dementia and memory loss. More recently, it has been accepted that people with dementia have insight into their condition and, therefore, the ability to contribute to research. A qualitative research project was undertaken with nine participants to explore the experiences and coping strategies of people with dementia. Interviews were undertaken and the data analysed using thematic analysis. Three major themes emerged: coming to terms with memory loss, maintaining control and independence, and the impact of illness on relationships. Understanding the reality for people is essential given that representations of the catastrophic impact of dementia generate high levels of anxiety and depression. Implications for nurses’ practice include the need for skilled, well-paced, sensitive and ongoing information about the condition, along with the need to recognize and support the active coping strategies of people with memory loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-172X.2005.00511.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    p53 is regulated by the lysine demethylase LSD1 (2007)
    [s.l.] : Nature Publishing Group
    Nature 449 (2007), S. 105-108 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] p53, the tumour suppressor and transcriptional activator, is regulated by numerous post-translational modifications, including lysine methylation. Histone lysine methylation has recently been shown to be reversible; however, it is not known whether non-histone proteins are substrates for ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature06092
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Repression of p53 activity by Smyd2-mediated methylation (2006)
    [s.l.] : Nature Publishing Group
    Nature 444 (2006), S. 629-632 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Specific sites of lysine methylation on histones correlate with either activation or repression of transcription. The tumour suppressor p53 (refs 4–7) is one of only a few non-histone proteins known to be regulated by lysine methylation. Here we report a lysine ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05287
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    Paper (German National Licenses)
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