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Assessment of genetic damage induced by dental bleaching agents on mouse lymphoma cells by single cell gel (comet) assay (2005)

RIBEIRO, D. A. ; MARQUES, M. E. A. ; SALVADORI, D. M. F.

Oxford, UK : Blackwell Science Ltd

Journal of oral rehabilitation 32 (2005), S. 0

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ISSN: 1365-2842

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: summary Dental bleaching is a simple and conservative procedure for aesthetic restoration of vital discoloured teeth. However, dental bleaching agents may represent a hazard to human health, especially by causing DNA strand breaks. Genotoxicity tests form an important part of cancer research and risk assessment of potential carcinogens. In the current study, the genotoxic potential associated with exposure to dental bleaching agents was assessed by the single cell gel (comet) assay in vitro. Six commercial dental bleaching agents (Clarigel Gold – Dentsply; Whitespeed – Discus Dental; Nite White – Discus Dental; Magic Bleaching – Vigodent; Whiteness HP – FGM and Lase Peroxide – DMC) were exposed to mouse lymphoma cells in vitro. The results pointed out that all dental bleaching agents tested contributed to the DNA damage as depicted by the mean tail moment. Clear concentration-related effects were obtained for DNA damaging, being the strongest effect observed at the highest dose of the hydrogen peroxide (Whiteness HP and Lase Peroxide, at 35% concentration). On the contrary, Whitespeed (Discus Dental) induced the lowest level of DNA breakage. Taken together, these results suggest that dental bleaching agents may be a factor that increases the level of DNA damage as detected by the single cell gel (comet) assay.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2842.2005.01500.x

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〈i〉In Vitro〈/i〉 Characterization of Porous Ceramic Based Calcium Phosphate Processing with Albumin (2008)

Ribeiro, Christiane ; Rojas-Cabrera, W.I. ; Marques, M. ; [et al.]

s.l. ; Stafa-Zurich, Switzerland

Key engineering materials Vol. 396-398 (Oct. 2008), p. 27-30

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ISSN: 1013-9826

Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: In recent years, the processing of porous ceramic materials for implant applications has motivated the development and optimization of new technologies. To this purpose, a globular protein based (i.e. ovalbumin) consolidation approach has been proposed. In the present study, a porous hydroxyapatite:b-tricalcium phosphate - biphasic ceramics (BCP), was processed by consolidation using the protein-action technique. The processed ceramic materials exhibited appropriate pore configuration in terms of size, morphology and distribution. The in vitro reactivity and dissolution behavior of the ceramics was evaluated in SBF and biocompatibility in an osteoblasts culture, respectively. Overall, the materials tested showed biocompatibility and suitable properties for osteoconduction. A rough surface pattern displayed by the ceramics seemed to have improved both; cell adhesion and proliferation processes. In conclusion, this study revealed that the porous matrices obtained, promoted suitable development of cell metabolism without cellular death