Electronic Resource
Oxford, UK; Malden, USA
:
Blackwell Science Inc
Wound repair and regeneration
13 (2005), S. 0
ISSN:
1524-475X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Aims: Recent studies have demonstrated that administration of recombinant IL-12 induces cytotoxicity against regenerating hepatocytes. We measured transcription levels of IL-12 in the remnant liver in a model of partial hepatectomy (PHx) to elucidate the mechanism of already reported facilitation of liver regeneration by recombinant human G-CSF (rhG-CSF).Methods: After PHx of F344 rats, total RNA of the remnant liver was extracted and mRNA levels of IL-12p35 and G-CSF were quantified by RT-real time PCR.Results: G-CSF mRNA levels increased and IL12p35 mRNA levels decreased at 6 and 20 hours after PHx (P 〈 0.01). Pre-PHx rhG-CSF treatment significantly further down-regulated IL12p35 mRNA levels at 20 hours (P 〈 0.01).Conclusions: This result suggests that rhG-CSF pretreatment accelerates tissue repair of the liver at least partially through regulation of cellular immunity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1067-1927.2005.130116ab.x
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