Electronic Resource
Palo Alto, Calif.
:
Annual Reviews
Annual Review of Microbiology
59 (2005), S. 357-377
ISSN:
0066-4227
Source:
Annual Reviews Electronic Back Volume Collection 1932-2001ff
Topics:
Biology
Notes:
Genome-wide studies of mRNA regulation and phenotypic responses have shown that eukaryotic cells mount a robust and multifaceted response upon exposure to DNA-damaging agents. The integration of theses studies over frameworks provided by protein-protein interactions, protein-DNA interactions, and subcellular localization information have led to the identification of networked responses to damage. Taken together, these studies illustrate that cellular protection from DNA and other macromolecular damage involves an intricate network of proteins involved in many different cellular functions, some of them expected (e.g., DNA repair and cell cycle checkpoints) but many of them unexpected (e.g., protein trafficking and degradation). This review highlights many of the studies that detail genome-wide responses to DNA-damaging agents and examines how these datasets have been used to build a systems view of cellular responses to damage.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1146/annurev.micro.59.031805.133658
Permalink
Library |
Location |
Call Number |
Volume/Issue/Year |
Availability |