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  • 2005-2009  (19)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 93 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in exon 1 of the Huntingtin (Htt) gene. We show herein that in an HD transgenic mouse model (R6/2), daily administration of CGS21680 (CGS), an A2A adenosine receptor (A2A-R)-selective agonist, delayed the progressive deterioration of motor performance and prevented a reduction in brain weight. 3D-µMRI analysis revealed that CGS reversed the enlarged ventricle-to-brain ratio of R6/2 mice, with particular improvements in the left and right ventricles. 1H-MRS showed that CGS significantly reduced the increased choline levels in the striatum. Immunohistochemical analyses further demonstrated that CGS reduced the size of ubiquitin-positive neuronal intranuclear inclusions (NIIs) in the striatum of R6/2 mice and ameliorated mutant Htt aggregation in a striatal progenitor cell line overexpressing mutant Htt with expanded polyQ. Moreover, chronic CGS treatment normalized the elevated blood glucose levels and reduced the overactivation of a major metabolic sensor [5′AMP-activated protein kinase (AMPK)] in the striatum of R6/2 mice. Since AMPK is a master switch for energy metabolism, modulation of energy dysfunction caused by the mutant Htt might contribute to the beneficial effects of CGS. Collectively, CGS is a potential drug candidate for the treatment of HD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2005.03029.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Genetic model of selective COX2 inhibition reveals novel heterodimer signaling (2006)
    [s.l.] : Nature Publishing Group
    Nature medicine 12 (2006), S. 699-704 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Selective inhibitors of cyclooxygenase-2 (COX2) have attracted widespread media attention because of evidence of an elevated risk of cardiovascular complications in placebo-controlled trials, resulting in the market withdrawal of some members of this class. These drugs block the cyclooxygenase ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1412
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Meso-Macro Scale Behavior Analysis of Polymeric Systems under their Melting States (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 33-37 (Mar. 2008), p. 1109-1114 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In this study, the meso-scale analysis are conducted by using the Disperse ParticleDynamics(DPD) analysis, and the constitutive equation model between viscosity and shear velocityare obtained by using different constrained mutual sufficient area. The macro-scale analysis areconducted by using Finite Element Method(FEM) based on the Computational FluidDynamics(CFD). The meso-scale model is smoothly coupled with in macro-scale model by using therelationships between the DPD meso-scale model and the FEM macro-scale model
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/40/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.33-37.1109.pdf
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Task Scheduling in Multi-Process with Resource Constraints under MG Workflow (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 33-37 (Mar. 2008), p. 1425-1430 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In manufacturing Grid workflow, multiple tasks share a common and limited resource pool.In order to solve task scheduling in multi-process with resource constraints under MG workflow, theTask-Resource Constrained model is set up to descript the assignment relation between task andresource. The framework of the task scheduling and the scheduling policies are also presented thatcan readjust the tasks according to the priority rules and the time parameters in the process. Then wepresent a heuristic scheduling algorithm that includes multiple policies. The heuristic schedulingalgorithm will update the critical path of DAG (Direct Acyclic Graph) and the beginning time ofpost-tasks. MG Workflow engine can dynamically schedule the resources according the taskrequirement. An example is given to illustrate the method at last
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/40/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.33-37.1425.pdf
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Study on Impact Fatigue Life of 42CrMo Steel with M+F Dual-Phase Structure (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 353-358 (Sept. 2007), p. 54-57 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The effect of undissolved ferrite amount on impact fatigue properties and failure mechanismwere studied by using 42CrMo steel with subcritical quenching process The amount of undissolvedferrite were 0%, 10% and 15%, respectively. The experimental results show that the existence ofundissolved ferrite can not only change the microstructure, but also increase the impact fatigue life Theimpact fatigue life elongates with increasing of amounts of undissolved ferrite The grain can be fined byusing subcritical quenching process and the area of phase boundaries can also be greatly increasedbecause of undissolved spheroidal carbide. The martensite and carbide form can also be changed byusing subcritical quenching process The stress relaxation due to the moving of dislocations inside theferrite and the promotion of strength due to occurring of plastic deformation and the enwindeddislocations are main reasons of improving the impact fatigue life. The impact fatigue life elongateswith the increase of amounts of undissolved ferrite before the amount of undissolved ferrite reaches 10%.Under the experiment conditions, when the amount of undissolved ferrite is 10%, the impact fatigue lifewill be the longest
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/55/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.353-358.54.pdf
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of External Loads on the Reliability of Welded Pipe with Circumferential Crack (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 353-358 (Sept. 2007), p. 2513-2516 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The reliability of welded pressure pipe with circumferential surface crack was calculated byusing 3-D stochastic finite element method. This method has overcome the shortcomings of conservativeresults in safety assessment with deterministic fracture mechanics method. The calculation of reliabilitywas based on 3-D elastic-plastic stochastic finite element program which was developed by ourselves.The effects of variables such as bending moment, the inner pressure on the structure reliability werediscussed. The calculation results indicate that the bending moment has great effect on the reliability ofthe welded pipe, and the inner pressure has little effect on the reliability of the welded pipe if the innerpressure is less than 10MPa. If the mean value of the inner pressure changed from 0.5MPa to 30MPa, thefailure probability will changes from 10-6 to 10-2. The bending moment also has great effect on thereliability. When the mean value of moment is changed from10000 Nm to 15000 Nm, the failureprobability of the welded pipe increases dramatically for the same inner pressure. Irrespective of thechanging of moment, the pipe has higher reliability if the inner pressure is less than 6 MPa. The methodhas put forward a new way for safety assessment of welded pipe with circumferential surface crack
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/55/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.353-358.2513.pdf
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    STIM1 is a Ca 2+ sensor that activates CRAC channels and migrates from the Ca 2+ store to the plasma membrane (2005)
    [s.l.] : Nature Publishing Group
    Nature 437 (2005), S. 902-905 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] As the sole Ca2+ entry mechanism in a variety of non-excitable cells, store-operated calcium (SOC) influx is important in Ca2+ signalling and many other cellular processes. A calcium-release-activated calcium (CRAC) channel in T lymphocytes is the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature04147
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    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai (2006)
    [s.l.] : Nature Publishing Group
    Nature 443 (2006), S. 226-229 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Recent RNA interference screens have identified several proteins that are essential for store-operated Ca2+ influx and Ca2+ release-activated Ca2+ (CRAC) channel activity in Drosophila and in mammals, including the transmembrane ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05108
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Directional Solidification of Undercooled Hypoeutectic Silver-Copper Alloy Melt (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 475-479 (Jan. 2005), p. 2607-2610 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Directional solidification of the undercooled melt which combines melt undercooling with conventional directional solidification is a new method of obtaining directional structure. This method is used to realize the directional solidification of the undercooled Ag70.3Cu29.7 melt. The experiment is performed in two steps: The undercooled melt is obtained by glass fluxing, and the above specimen is remelted and excited with Ga-In-Sn coolant. By this method, directional solidification dendrites of Ag70.3Cu29.7 alloy are achieved successfully. The columnar dendrites are straight and fine. The primary arm spacing is 21µm in average for a 65K undercooling, as compared to 38µm for a 32K undercooling. This confirms that higher undercooling promotes finer dendritic microstructures
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/09/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.475-479.2607.pdf
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Study on Bending Fatigue Life of 42CrMo Steel with M+F Dual-Phase Structure (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 324-325 (Nov. 2006), p. 879-882 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The effect of undissolved ferrite amount on bending fatigue properties and failuremechanism were studied by using 42CrMo steel with subcritical quenching process The amount ofundissolved ferrite were 0%, 10% and 15%, respectively. The hardness of the specimen was treatedto medium hardness. The experimental results show that the existence of undissolved ferrite can notonly change the microstructure, but also increase the bending fatigue life. The bending fatigue lifeelongates with increasing of amounts of undissolved ferrite. The grains can be fined by usingsubcritical quenching process and the area of phase boundaries can also be greatly increasedbecause of undissolved spheroidal carbide. The martensite and carbide can also be changed usingsubcritical quenching process. Stress relaxation due to the move of dislocations inside the ferriteand the promotion of strength due to occurring of plastic deformation and enwinded dislocations aremain reasons of improving the bending fatigue life. The bending fatigue life elongates with theincrease of amounts of undissolved ferrite before the amount of undissolved ferrite reaches 10%.Under the experiment conditions, when the amount of undissolved ferrite is 10%, the bendingfatigue life will be the longest
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.324-325.879.pdf
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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