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  • 2005-2009  (99)
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  • 1
    Electronic Resource
    Electronic Resource
    Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 94 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Although of clinical importance, little is known about the mechanism of seizure in neuronal ceroid lipofuscinosis (NCL). In the present study, we have attempted to elucidate the mechanism underlying the seizure of cathepsin D-deficient (CD–/–) mice that show a novel type of lysosomal storage disease with a phenotype resembling late infantile NCL. In hippocampal slices prepared from CD–/– mice at post-natal day (P)24, spontaneous burst discharges were recorded from CA3 pyramidal cells. At P24, the mean amplitude of IPSPs after stimulation of the mossy fibres was significantly smaller than that of wild-type mice, which was substantiated by the decreased level of γ-aminobutyric acid (GABA) contents in the hippocampus measured by high-performance liquid chromatography (HPLC). At this stage, activated microglia were found to accumulate in the pyramidal cell layer of the hippocampal CA3 subfield of CD–/– mice. However, there was no significant change in the numerical density of GABAergic interneurons in the CA3 subfield of CD–/– mice at P24, estimated by counting the number of glutamate decarboxylase (GAD) 67-immunoreactive somata. In the hippocampus and the cortex of CD–/– mice at P24, some GABAergic interneurons displayed extremely high somatic granular immunoreactivites for GAD67, suggesting the lysosomal accumulation of GAD67. GAD67 levels in axon terminals abutting on to perisomatic regions of hippocampal CA3 pyramidal cells was not significantly changed in CD–/– mice even at P24, whereas the total protein levels of GAD67 in both the hippocampus and the cortex of CD–/– mice after P24 were significantly decreased as a result of degradation. Furthermore, the recombinant human GAD65/67 was rapidly digested by the lysosomal fraction prepared from the whole brain of wild-type and CD–/– mice. These observations strongly suggest that the reduction of GABA contents, presumably because of lysosomal degradation of GAD67 and lysosomal accumulation of its degraded forms, are responsible for the dysfunction of GABAergic interneurons in the hippocampal CA3 subfield of CD–/– mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2005.03250.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Implementing value-transparency in supply relations (2005)
    Bingley : Emerald
    Management decision 43 (2005), S. 810-820 
    Details
    ISSN: 0025-1747
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Purpose - To explore and identify the strategic approaches firms may follow in their pursuit of value transparency (VT) in inter-organisational relations in supply networks. Design/methodology/approach - Through the use of game theory an understanding of the difficulties of co-operation and information transfer is developed. Game theory and marginal analysis facilitate an advanced application of VT. Findings - While the article acknowledges the limitations of prescriptive precision in strategy matters, it is not proposed that firms would follow any single part of the outlined strategies. However, through rational analysis of the strategic options presented it may be possible to foresee potential negative outcomes, and through structuring undesirable scenarios managers may be able to reduce the risk of their occurrence. Practical implications - A model is proposed that aids firms in the selection of supply partners for VT and VT modes. Recognising that certain conditions will be more likely to support a more rapid and extensive adoption of VT, the paper identifies the role that aspects of organisations' economic environments may play. Originality/value - The article acknowledges the limitations of modelling and game theory-based approaches but suggests that through considering the interests and benefits of the other party, practical insights may be developed and the likely outcomes of various scenarios considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/00251740510603574
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4–binding residues (2006)
    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 13 (2006), S. 77-84 
    Details
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The four mammalian SPRY domain–containing SOCS box proteins (SSB-1 to SSB-4) are characterized by a C-terminal SOCS box and a central SPRY domain. We have determined the first SPRY-domain structure, as part of SSB-2, by NMR. This domain adopts a novel fold consisting of a β-sandwich ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nsmb1034
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Preparation and Upconversion Properties of Yb3+, Ho3+: Lu2O3 Nanocrystalline Powders (2005)
    Oxford, UK : Blackwell Science Inc
    Journal of the American Ceramic Society 88 (2005), S. 0 
    Details
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Yb3+, Ho3+: Lu2O3 nanocrystalline powders were synthesized by a reverse-strike co-precipitation method using NH4HCO3 and NH3·H2O as precipitators. X-ray diffraction analysis and field emission scanning electron microscopy observation showed that the phase composition of the powders was cubic and the particle size was 30–50 nm. Under the excitation of a 980 nm continuous wave diode laser, green and red emissions centered around 548 and 667 nm, respectively, were observed and the green emission dominated the upconversion spectrum. Power studies revealed that a two-photon process was involved in the upconversion emissions and the possible upconversion mechanisms were discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1551-2916.2005.00192.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The Influences of Size and Anisotropy Strength on Hysteresis Scaling for Anisotropy Heisenberg Multilayer Films (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 121-123 (Mar. 2007), p. 1085-1088 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: In this paper, we simulate the magnetization dynamic processes of the multilayer films,and calculate their hysteresis loop areas using Monte Carlo method. The simulated results indicatethat, the size and anisotropy strength of the anisotropy multilayer films influence evidently thedynamic phase transition, and the phase transition temperature increases with enhancing values ofthe anisotropy constant and layer thickness. It is also found that, with increasing number of layers offilms, the value of α decreases, while the magnitudes of β and γ increase. On the contrary, withincreasing anisotropy strength, the value of α increases, while the magnitudes of β and γ reduce
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/23/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.121-123.1085.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    AF/PSTM and Its Application in Nanometer Material Measurement (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 121-123 (Mar. 2007), p. 859-862 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/23/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.121-123.859.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Stochastic Characteristics of Fatigue Crack Propagation for 2024-T3 Aluminium Alloy in Corrosive Environments (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 348-349 (Sept. 2007), p. 517-520 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Crack propagation tests were conducted with CCT specimens made by 2024-T3 Aluminumalloy in benign and corrosive environments to investigate the stochastic characteristics of crackgrowth. A random variable probability crack growth model, base on the modified form of Paris law,was used to characterize the stochastic performance. Distribution significance test has been done,which shows that the random variable X can be considered reasonably to follow log-normaldistribution in all the 4 kind of environments. Variance analysis indicates that the scatter in wet air isgreater than that in laboratory air significantly. Expressions for the probability distribution of cracksize at any given loading cycle and the probability distribution of the random fatigue life at which agiven crack size is reached were discussed. The corresponding calculations for the crack lengthdistribution and P-a-N curves with certain reliability were carried out. The comparisons withexperimental data indicate the validity of the proposed method
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/55/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.348-349.517.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Modeling and Testing Strain Rate-Dependent Tensile Strength of Carbon/Epoxy Composites (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 353-358 (Sept. 2007), p. 1418-1421 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Tensile strength is an important material property and usually can be determinedexperimentally. The strain rate dependent behavior of T300 carbon/epoxy matrix composite wascharacterized over a wide strain rate range (10×10-5 s-1to10×104s-1). The low to moderate strain rateexperiments were carried out on a MTS machine, while the high strain rate experiment wasconducted with a split Hopkinson tensile bar. A rate dependent model was introduced to simulatethe material response. Two kinds of stacking sequence of composite specimens [(45/-45)4]s and[(0/45/90/-45)2]s were tested at different strain rates, and the results were used to determineparameters of the model. The predictions of the model showed to agree fairly well with theexperimental results. The tensile strength and initial elastic modulus of the composites increasewhen the strain rate increases
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/55/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.353-358.1418.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Preparation and Characterization of Cr〈sub〉2〈/sub〉O〈sub〉3〈/sub〉 Nano-Powders by Sol-Gel Method (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 353-358 (Sept. 2007), p. 2111-2114 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Cr2O3 nano-powders were successfully fabricated with using chromium nitrate andaqueous ammonia as starting material and urea as dispersant agent by sol-gel method. Theformation of crystalline phase during heat treatment of dry gel was characterized by differentialthermogravimetry (DTG) and X-ray diffraction (XRD) techniques and the temperature ofcalcination was determined as 400°C. Scanning electron microscopy (SEM) was utilized to observethe morphology of the as-fabricated Cr2O3 particles. The results showed that Cr2O3 particles arespherical or square with little agglomeration and a diameter of about 30 nm. The specific surfacearea of Cr2O3 particles was measured as 44.23 m2/g by Brunauer-Emmett-Teller (BET)
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/55/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.353-358.2111.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Fabrication of WC-6Co-1.5Al (wt%) Hardmetal by High Energy Milling and Electrical Current Sintering (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 359-360 (Nov. 2007), p. 409-413 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Ultrafine grain WC hardmetals were manufactured successfully from mixed powders ofnominal composition of WC-6Co-1.5Al(wt%). To manufacture bulk ultrafine grain WC alloys,nanocrystalline WC powders as precursor were prepared for sintering from the mixed commerciallyavailable powders by high energy milling of 15 h. Then the electrical current sintering process ofthe milled powders was further studied. Experimental results showed that the density, hardness andtransverse rupture strength of the sintered alloys reached 14.224 g/cm3, HRA 94 and 1660 MPa,respectively, by a appropriate coupling of pulse- and subsequent constant-current sintering and withthe total sintering time of 6 min. It seemed difficult to obtain desirable sintered hardmetal by asingle type of electric current sintering. However, the application of intensive pulse electric currentwas favorable to sintering, although it was difficult to achieve good WC alloys only by the pulseelectric current sintering. A higher density WC alloy could be prepared by enlarging the electriccurrent when only constant electric current was applied to sinter the milled powders. Unfortunately,the WC grains substantially coarsened concurrently so that the mechanical properties of the assintered alloy decreased obviously
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/55/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.359-360.409.pdf
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