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  • 2000-2004
  • 1995-1999  (2)
  • 1975-1979
  • PACS. 71.27.+a Strongly correlated electron systems; heavy fermions - 75.40.Mg Numerical simulation studies  (1)
  • chemotherapy  (1)
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  • 2000-2004
  • 1995-1999  (2)
  • 1975-1979
Year
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  • 1
    ISSN: 1569-8041
    Keywords: chemotherapy ; drugs ; generics ; prioritization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The WHO has previously produced recommendations on the essential drugs required for cancer therapy. Over the last five years several new anti cancer drugs have been aggressively marketed. Most of these are costly and produce only limited benefits. We have divided currently available anti-cancer drugs into three priority groups. Curable cancers and those cancers where the cost-benefit ratio clearly favours drug treatment can be managed appropriately with regimens based on only 17 drugs. All of these are available, at relatively low cost, as generic preparations. The wide availability of these drugs should be the first priority. The second group of drugs may have some advantages in certain clinical situations. Based on current evidence, drugs in the third group are judged as currently not essential for the effective delivery of cancer care. Adequate supportive care programmes with the widespread availability of effective drugs for pain control are of considerably greater importance. The adoption of these priorities will help to optimise the effectiveness and efficiency of chemotherapy and ensure equitable access to essential drugs especially in low resource environments. Clearly this paper represents the views of its contributors. The WHO welcomes feedback from all oncologists so that the advice it gives to governments in prioritising the procurement of anti cancer drugs can be as comprehensive as possible.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-6036
    Keywords: PACS. 71.27.+a Strongly correlated electron systems; heavy fermions - 75.40.Mg Numerical simulation studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: Specific heat (CV) measurements in the spin-1/2 Cu2(C2H12N2)2Cl4 system under a magnetic field up to H =8.25 T are reported and compared to the results of numerical calculations based on the 2-leg antiferromagnetic Heisenberg ladder. While the temperature dependences of both the susceptibility and the low-field specific heat are accurately reproduced by this model, deviations are observed above the critical field HC1 at which the spin gap closes. In this Quantum High Field phase, the contribution of the low-energy quantum fluctuations are stronger than in the Heisenberg ladder model. We argue that this enhancement can be attributed to dynamical lattice fluctuations. Finally, we show that such a Heisenberg ladder, for H 〉 H C1, is unstable, when coupled to the 3D lattice, against a lattice distortion. These results provide an alternative explanation for the observed low temperature ( K-0.8 K) phase (previously interpreted as a 3D magnetic ordering) as a new type of incommensurate gapped state.
    Type of Medium: Electronic Resource
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