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  • 2000-2004  (11)
  • 1995-1999  (7)
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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical psychology 10 (2003), S. 0 
    ISSN: 1468-2850
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Notes: Older adults are the fastest growing subpopulation in the United States, and it is likely that the demand for well-trained clinical geropsychologists will expand. This trend has important implications for research and graduate training. One promising area of research concerns the most effective ways of dealing with long-term illness in partners of older adults. With regard to training, we point out that the connection between neuropsychology and geropsychology needs further emphasis. Increasing the number of geropsychology programs is clearly desirable, and further funding to support and increase the number of such programs should be of high priority. Two recent developments are also highlighted. The first involves a federal court case that addresses the relationship between physical and mental illness, an issue particularly important to mental health parity concerning insurance reimbursements. The second issue concerns prescription privileges for psychologists in view of the recently passed law in New Mexico permitting psychologists to prescribe medicine. This article discusses the implications of these developments.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The origin of replication of the P1 plasmid contains five direct, imperfect repeats (iterons) of a 19 bp sequence that binds the P1-encoded RepA initiator protein. RepA binding to these iterons triggers origin initiation and represses transcription from the repA promoter that is nested within the iterons. The origin iterons were replaced with ligated oligonucleotides that insert five perfect 19 bp repeats with identical spacer sequences. This eliminates the natural variation in the iteron and spacer sequences and removes the repA promoter. The reconstructed origin is functional, showing that the repA promoter is not essential for origin function. The method used to make the reconstructed origin allows substitution of identical iterons with altered sequence or spacer length. Single changes of conserved iteron bases gave reduced or non-existent origin activity, as did an increase in spacer length. Like the wild type, most of these mutant arrays retain avid primary binding activity for the RepA protein. However, although the wild-type arrays readily form a mature complex in which all iterons are saturated, the most replication-defective mutants were completely unable to do this, even at very high RepA concentrations. It appears that iteron spacing and contacts involving at least three of the conserved iteron bases play an important role in the assembly of the mature structure in which all sites are occupied. A model is presented in which an allosteric interaction between the DNA site and protein is needed for the saturated, mature complex required for initiation.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Osney Mead, Oxford OX2 0EL, UK : Blackwell Science Ltd
    Molecular microbiology 18 (1995), S. 0 
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The incA locus of plasmid P1 controls plasmid copy number by inhibiting the replication origin, oriR. Both loci contain repeat sequences (iterons) that bind the P1 RepA protein. Regulation appears to occur by contact of incA and oriR loci of daughter plasmids mediated by RepA-bound iterons. Synthetic incA iteron arrays were constructed with altered numbers, sequences or spacing of iterons. Using these in in vitro and in vivo assays, we examined two models: (i) that the origin and incA loci form a stable 1:1 complex in which multiple iterons of each locus are paired with those of the other, and (ii) that individual incA iterons act as freely diffusing nucleoprotein units that contact origin iterons in a random and dynamic fashion. The data presented here strongly favour the latter case. The origin, with its five iterons, acts as a target but not as an effector of regulation. We present a model for replication control based on random, dynamic contacts between incA iterons and the origin. This system would display randomness with respect to choice of templates and timing of initiation if multiple replicon copies were present, but would tend to act in a machine-like fashion in concert with the cell cycle if just two copies were present in a dividing cell.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    On the horizon 9 (2001), S. 2-4 
    ISSN: 1085-4959
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Education , Economics
    Notes: This editorial looks at some of the forces that are acting on the university, both internally and externally. We look at the impact of globalization in this article.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    On the horizon 9 (2001), S. 2-3 
    ISSN: 1085-4959
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Education , Economics
    Notes: This editorial continues our look at some of the forces that are acting on the university, both internally and externally. In this issue we look at the impact of lifelong learning. Universities use great expenses to recruit students, but are not retaining them as part of the community once they have graduated. The loss of alumni from the community is a great disadvantage to the institution and actively discourages collaborative learning.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    On the horizon 9 (2001), S. 2-3 
    ISSN: 1085-4959
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Education , Economics
    Notes: On the Horizon was born in the mind of our current Editor Emeritus, Jim Morrison, as an environmental scanning journal. Published for a number of years by Jossey-Bass, On the Horizon was acquired by a small, selective, house in the UK, Camford. Today we are pleased to announce that OTH will be published by Emerald, http://emeraldinsight.com, a major international publisher of over 130 professional journals. Beginning with Volume 10, in January 2002, OTH becomes a quarterly, doubled in size with expanded features, longer, more in-depth articles, and a global focus, as it adds regional editors to its board.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    On the horizon 9 (2001), S. 2-3 
    ISSN: 1085-4959
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Education , Economics
    Notes: Filtering out useful bits of information, in a world awash with information, is becoming very costly. Not only must we consider the information itself, but we must also consider the factor of time. When in time and space is it important and what is its half-life?
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    On the horizon 11 (2003), S. 3-5 
    ISSN: 1085-4959
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Education , Economics
    Notes: The high cost of academic journals has led researchers to seek alternative venues for both publishing and accessing scholarly research. The Internet will provide an appropriate vehicle once there is a model which is not a simple mapping of brick space into click space. This will require The Academy to apply knowledge management to their own practices.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    On the horizon 9 (2001), S. 2-4 
    ISSN: 1085-4959
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Education , Economics
    Notes: Discusses changes that will affect the Academy in the new Millennium. Explores the impact of the Internet on many aspects of academic life, including scholarly communication and publications, collaborative research, e-education, and entrepreneurship in education.
    Type of Medium: Electronic Resource
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