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  • 2000-2004  (3)
  • 1995-1999  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Gene expression patterns in Atlantic salmon Salmo salar: gene expression during osmoregulation in intestine tissue (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Journal of fish biology 65 (2004), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Ireland has the world's largest stocks of wild Atlantic salmon. A better understanding of gene expression will benefit conservation of wild stock as well as salmon aquaculture. We describe the PRTLI project designed to advance the fundamental understanding of the genome of Atlantic Salmon Salmo salar. The major objective is to create the first comprehensive database of gene expression and functional information using cDNA libraries and Microarray technology. One key area of interest to salmon biology is osmoregulation, which is critical to the ability of salmon to adapt in seawater. Tissues implicated in this process are the gills, intestine and skin. To initiate studies, SSH (suppression subtractive hybridization) libraries were constructed from intestine RNA extracted from smolts sampled in January and May. A number of potentially interesting clones have been identified, among those a heat shock protein, hsp90 in the reverse library. Others SSH libraries from various tissues (pituitary, hypothalamus, brain, gill, intestine, head kidney and spleen) have also been constructed and will be used to construct a 5000 clone microarray slide. This slide will then be used to elucidate gene expression profiles in various tissues. Further sample collection has been carried out to answer questions regarding biologicaldifferences between one- year and two-year old parr and wild and hatchery smolt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.2004.559aj.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Changes in mucus cell numbers in the epidermis of the Atlantic salmon at the onset of smoltification (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of fish biology 63 (2003), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: A sharp decrease to 〈50% in the numbers of mucus cells mm−2 of epidermis was observed in the skin of Atlantic salmon Salmo salar at the beginning of the smoltification period in 1997 and 1999. Average numbers decreased in 1997 from 662 mm−2 on 6 March to 275 mm−2 on 20 March and in 1999 from 828 mm−2 on 3 March to 388 mm2 on 24 March. A second smaller decrease was observed towards the end of smoltification in both years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.2003.00273.x
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  • 3
    Electronic Resource
    Electronic Resource
    Differential lifetime success and performance of native and non-native Atlantic salmon examined under communal natural conditions (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Journal of fish biology 65 (2004), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The lifetime success and performance characteristics of communally reared offspring of wild native Burrishoole (native), ranched native (ranched) and non-native (non-native) Atlantic salmon Salmo salar from the adjacent Owenmore River were compared. Non-native 0+ year parr showed a substantial downstream migration, which was not shown by native and ranched parr. This appears to have been an active migration rather than competitive displacement and may reflect an adaptation to environmental or physiographic conditions within the Owenmore River catchment where the main nursery habitat is downstream of the spawning area. There were no differences between native and ranched in smolt output or adult return. Both of these measures, however, were significantly lower for the non-native group. A greater proportion of the non-native Atlantic salmon was taken in the coastal drift nets compared to the return to the Burrishoole system, probably as a result of the greater size of the non-native fish. The overall lifetime success of the non-native group, from fertilized egg to returning adult, was some 35% of native and ranched. The ranched group showed a significantly greater male parr maturity, a greater proportion of 1+ year smolts, and differences in sex ratio and timing of freshwater entry of returning adults compared to native, which may have fitness implications under specific conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0022-1112.2004.00557.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Disturbance of Notch-1 and Wnt signalling proteins in neuroglial balloon cells and abnormal large neurons in focal cortical dysplasia in human cortex (1999)
    Springer
    Acta neuropathologica 98 (1999), S. 465-472 
    Details
    ISSN: 1432-0533
    Keywords: Key words Focal ; Cortical ; Dysplasia ; Wnt ; Notch
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Determination of neuroglial cell fate and neural tube development during embryogenesis is influenced by the Notch/Wnt signalling pathway. We have studied the localisation of several proteins in the Wnt pathway in focal cortical dysplasia (FCD). This disorder, thought to be due to abnormalities of neuronal migration and differentiation, contains regions of morphologically normal neocortex interrupted by areas of neuronal laminar disorganisation, heterotopic white matter neurons, abnormal large neurons and balloon cells of uncertain histogenesis. We found that the subcellular distribution of several proteins involved in the Wnt pathway differed in regions of FCD from normal cortex, and that within the areas of FCD, the pattern varied with cellular phenotype. Thus, in balloon cells, elevated cytoplasmic levels of dishevelled (Dvl-1) protein were accompanied by an absence of Notch-1, increased adenomatous poliposis coli (APC), altered cytoplasmic β-catenin, and reduced nuclear expression of β-catenin. A contrasting pattern of expression was found in abnormal large neurons, which demonstrated elevated levels of Notch-1, and glycogen synthase kinase-3β (GSK-3β), and normal levels of APC. Our results are consistent with the notion that Wnt/Notch signalling influences neuroglial cell fate, and suggest that a perturbation of Wnt/Notch signalling may contribute to the neuropathology of FCD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051111
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The assessment of postmortem brain volume; a comparison of stereological and planimetric methodologies (1999)
    Springer
    Neuroradiology 41 (1999), S. 493-496 
    Details
    ISSN: 1432-1920
    Keywords: Key words Magnetic resonance imaging ; Stereology ; Planimetry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We compared two methods of estimating the volume of 10 formalin-fixed brains using MRI. MRI was performed and total brain volume was then assessed using two distinct techniques: a stereological point-counting technique based on the Cavalieri principle, and an edge-tracing technique. The total brain volumes obtained using these two techniques were similar and correlated closely with each other (r = 0.97). Both methods could be optimised to a similar degree while maintaining the coefficient of error at an acceptably low level. However, the stereological assessment of brain volume required between 20 min and 30 min per brain, depending on the number of points per sampling grid, compared with 1 h per brain using the planimetric method. Thus, while planimetric and stereological approaches yield very similar results, the stereological method has the advantage of greater speed and, therefore, efficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050789
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    Paper (German National Licenses)
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