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  • 2000-2004  (3)
  • 1995-1999  (3)
  • 1
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 41 (2000), S. 6007-6025 
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: In this paper we study the Bardeen–Cooper–Schrieffer energy gap equation at finite temperatures. When the kernel is positive representing a phonon-dominant phase in a superconductor, the existence and uniqueness of a gap solution is established in a class which contains solutions obtainable from bounded domain approximations. The critical temperatures that characterize superconducting–normal phase transitions realized by bounded domain approximations and full space solutions are also investigated. It is shown under some sufficient conditions that these temperatures are identical. In this case the uniqueness of a full space solution follows directly. We will also present some examples for the nonuniqueness of solutions. The case of a kernel function with varying signs is also considered. It is shown that, at low temperatures, there exist nonzero gap solutions indicating a superconducting phase, while at high temperatures, the only solution is the zero solution, representing the dominance of the normal phase, which establishes again the existence of a transition temperature. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Tegaserod (HTF 919) is a selective 5-HT4 receptor partial agonist in development for the treatment of irritable bowel syndrome.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:This study aimed to assess the effect of age and gender on the single-dose pharmacokinetics of tegaserod.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:In a parallel-group, open-label study, a single dose of tegaserod (12 mg) was administered to four groups of healthy young male, young female, elderly male and elderly female subjects (n=10 per group). Blood samples were collected from 0 to 24 h postdose. Non-compartmental pharmacokinetics evaluation and statistical analysis (ANOVA and Wilcoxon signed ranks test for tmax) were performed.〈section xml:id="abs1-4"〉〈title type="main"〉Results:Tegaserod was well tolerated in all groups. There was no effect of age or gender on tmax and Cmax. Gender did not affect AUC0–∞ and AUC0–tz; there was a statistically significant effect of age on these parameters. AUC0–∞ and AUC0–tz in the elderly were greater than in the young (AUC0–∞ ratio 1.37, P 〈 0.001; AUC0–tz ratio 1.23, P=0.029). This increase in exposure is judged not to be clinically relevant because it is within the variability in the pharmacokinetics parameters of tegaserod and because the dose–response relationship of tegaserod is relatively shallow.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:No dose adjustment for age or gender is recommended in tegaserod therapy.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 56 (2000), S. 129-133 
    ISSN: 1432-1041
    Keywords: Key words Type-2 diabetes mellitus ; Nateglinide ; Insulin secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objectives: Pharmacodynamic effects of nateglinide, a novel antidiabetic agent, were investigated in patients with type-2 diabetes mellitus. Methods: Ten patients participated in this single-center, double-blind, crossover study. Plasma glucose and insulin levels were measured over 24 h following five 7-day treatment periods with nateglinide (30, 60, or 120 mg) or placebo given three times daily before breakfast, lunch, and dinner. A fifth treatment consisted of 120 mg nateglinide four times daily, with the fourth dose given before an evening snack. Results: Taken 10 min before meals, doses of 30–120 mg nateglinide caused dose-dependent increases in plasma insulin levels that were significantly greater than with placebo. Higher doses were more effective and had a longer duration of action than lower doses. Nateglinide was also significantly better than placebo in lowering plasma glucose levels; the 60-mg and 120-mg doses were similarly effective and superior to the 30-mg nateglinide treatment. Following the fourth 120-mg dose, the glucose-lowering effects of treatment were maintained through the night. No serious adverse events occurred during the study. There were no events of hypoglycemia and no clinically meaningful changes in safety parameters. Conclusions: Nateglinide produced rapid, short-lived, dose-related increases in plasma insulin that significantly lowered mealtime glucose excursions compared with placebo with no incidence of hypoglycemia. The decrease in mealtime glucose levels produced a significant improvement in overall 24-h glycemia.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archive for rational mechanics and analysis 143 (1998), S. 241-271 
    ISSN: 1432-0673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract. In this work we propose a new method for investigating connection problems for the class of nonlinear second‐order differential equations known as the Painlevé equations. Such problems can be characterized by the question as to how the asymptotic behaviours of solutions are related as the independent variable is allowed to pass towards infinity along different directions in the complex plane. Connection problems have been previously tackled by a variety of methods. Frequently these are based on the ideas of isomonodromic deformation and the matching of WKB solutions. However, the implementation of these methods often tends to be heuristic in nature and so the task of rigorising the process is complicated. The method we propose here develops uniform approximations to solutions. This removes the need to match solutions, is rigorous, and can lead to the solution of connection problems with minimal computational effort. Our method relies on finding uniform approximations of differ ential equations of the generic form $$ \frac{{\text d}^2\phi}{{\text d}\eta^2} = - \xi^2F(\eta,\xi)\phi $$ as the complex‐valued parameter $\xi \to \infty$ . The details of the treatment rely heavily on the locations of the zeros of the function F in this limit. If they are isolated, then a uniform approximation to solutions can be derived in terms of Airy functions of suitable argument. On the other hand, if two of the zeros of F coalesce as $|\xi| \to \infty$ , then an approximation can be derived in terms of parabolic cylinder functions. In this paper we discuss both cases, but illustrate our technique in action by applying the parabolic cylinder case to the “classical” connection problem associated with the second Painlevé transcendent. Future papers will show how the technique can be applied with very little change to the other Painlevé equations, and to the wider problem of the asymptotic behavio ur of the general solution to any of these equations.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archive for rational mechanics and analysis 133 (1996), S. 199-247 
    ISSN: 1432-0673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract We study the dynamics of pattern formation in the one-dimensional partial differential equation $$u_u - (W'(u_x ))_x - u_{xxt} + u = 0{\text{ (}}u = u(x,t),{\text{ }}x \in (0,1),{\text{ }}t 〉 0)$$ proposed recently by Ball, Holmes, James, Pego & Swart [BHJPS] as a mathematical “cartoon” for the dynamic formation of microstructures observed in various crystalline solids. Here W is a double-well potential like 1/4((u x )2 −1)2. What makes this equation interesting and unusual is that it possesses as a Lyapunov function a free energy (consisting of kinetic energy plus a nonconvex “elastic” energy, but no interfacial energy contribution) which does not attain a minimum but favours the formation of finer and finer phase mixtures: $$E[u,u_t ] = \int\limits_0^1 {(\frac{{u_t^2 }}{2} + W(u_x ) + \frac{{u^2 }}{2})dx.}$$ Our analysis of the dynamics confirms the following surprising and striking difference between statics and dynamics, conjectured in [BHJPS] on the basis of numerical simulations of Swart & Holmes [SH]: •While minimizing the above energy predicts infinitely fine patterns (mathematically: weak but not strong convergence of all minimizing sequences (u nvn) of E[u,v] in the Sobolev space W 1 p(0, 1)×L2(0,1)), solutions to the evolution equation of ball et al. typically develop patterns of small but finite length scale (mathematically: strong convergence in W 1 p(0,1)×L2(0,1) of all solutions (u(t),ut(t)) with low initial energy as time t → ∞). Moreover, in order to understand the finer details of why the dynamics fails to mimic the behaviour of minimizing sequences and how solutions select their limiting pattern, we present a detailed analysis of the evolution of a restricted class of initial data — those where the strain field u x has a transition layer structure; our analysis includes proofs that •at low energy, the number of phases is in fact exactly preserved, that is, there is no nucleation or coarsening •transition layers lock in and steepen exponentially fast, converging to discontinuous stationary sharp interfaces as time t → ∞ •the limiting patterns — while not minimizing energy globally — are ‘relative minimizers’ in the weak sense of the calculus of variations, that is, minimizers among all patterns which share the same strain interface positions.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Archive for rational mechanics and analysis 147 (1999), S. 179-196 
    ISSN: 1432-0673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Type of Medium: Electronic Resource
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