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  • 1
    Electronic Resource
    Electronic Resource
    Unsteady magnetohydrodynamic flows in a rotating elastico-viscous fluid (1994)
    Springer
    Astrophysics and space science 219 (1994), S. 257-264 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract This paper points out the errors in the solutions of a research work by N. Nanousis under the same title published in this journal, volume 199, 1993. The correct solutions of the problem for the velocity field and the drag on the plate, by the Laplace transform technique, are presented. The results are discussed for two cases of an arbitrary time-dependent forcing effect. It is shown that the viscoelastic parameterk 〉 0 influences the velocity and introduces reverse flow. For a suddenly accelerated plate,k 〉 0 increases the velocity forz 〈 $$\sqrt {2t} $$ and decreases it forz 〉 $$\sqrt {2t} $$ . In the case of the ramp-type boundary condition,k 〉 0 tends to decrease the velocity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00628242
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  • 2
    Electronic Resource
    Electronic Resource
    Pairwise-balanced, variance-balanced and resistant incomplete block designs revisited (1990)
    Springer
    Annals of the Institute of Statistical Mathematics 42 (1990), S. 163-171 
    Details
    ISSN: 1572-9052
    Keywords: Block design ; pairwise balance ; variance balance ; resistance ; BIB design
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract A general solution is derived to the problem of characterizing block designs that are simultaneously pairwise-balanced and variance-balanced. Applications of the characterizations obtained to some problems concerned with the local resistance of BIB designs are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00050787
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  • 3
    Electronic Resource
    Electronic Resource
    The effects of induced magnetic field on unsteady hydromagnetic flows in a rotating medium (1990)
    Springer
    Astrophysics and space science 174 (1990), S. 121-133 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Unsteady flows of a viscous incompressible electrically conducting fluid filling the semi-infinite space in contact with an infinite conducting plate in a rotating medium in the presence of a transverse induced magnetic field are investigated under an arbitrary time-dependent forcing effect on the motion of the plate where the plate and the fluid rotate uniformly as a rigid body. By using the Laplace transform technique, the Greens function of the problem is determined and certain asymptotic expansions of the exact solutions are analyzed. the steady-state oscillatory flow problem is solved, and structure of waves and displacement thickness of the boundary layers are discussed for different cases of some natural parameters in the problem. The results are compared with similar flows in the presence of a constant magnetic field.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00645658
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  • 4
    Electronic Resource
    Electronic Resource
    Fluctuating flow of a viscous fluid on a porous plate in a rotating medium (1975)
    Springer
    Acta mechanica 21 (1975), S. 153-158 
    Details
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01172834
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  • 5
    Electronic Resource
    Electronic Resource
    Hirschsprung's disease in association with trisomy 21 and duodenal obstruction (1994)
    Springer
    Pediatric surgery international 9 (1994), S. 366-367 
    Details
    ISSN: 1437-9813
    Keywords: Hirschsprung's disease ; Trisomy 21 ; Duodenal obstruction ; Child
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The association of trisomy 21 and Hirschsprung's disease (HD) is well known. In a neonate, HD characteristically presents with delayed passage of meconium and/or intestinal obstruction. However, the presence of duodenal atreasia (DA), which may present similarly, can mask the associated HD. Over an 18-year period, 17 of 135 patients with HD had trisomy 21. Three of these 17 patients presented with duodenal obstruction in the newborn period — 2 had DA and 1 a complete duodenal web. One patient developed a perforation of the jejunum 7 days after laparotomy and duodenoduodenostomy and was found to have HD while the other 2 were later investigated because of persistent unresponsive constipation and confirmed to have HD at 1 and 2 years of age. In spite of associated Down's syndrome and DA, the possibility of HD should be considered in patients who have a complicated postoperative course or persisting abnormal stooling patterns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01686003
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  • 6
    Electronic Resource
    Electronic Resource
    Neonatal intestinal perforation in Hirschsprung's disease (1994)
    Springer
    Pediatric surgery international 9 (1994), S. 501-502 
    Details
    ISSN: 1437-9813
    Keywords: Hirschsprung's disease ; Intestinal perforation ; Neonate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Over a period of 18 years, 77 of 135 patients treated for Hirschsprung's disease (HD) presented in the neonatal period. Of these 77 patients, 8 had gastrointestinal (GI) perforations. Seven patients were born at full term and 1 at 32 weeks of gestation. Three patients had associated trisomy 21. The site of perforation included rectum in 1 patient, sigmoid in 1, descending colon in 1, transverse colon in 2, caecum in 2, and jejunum in 1. Perforations occurred in ganglionic bowel in 7 patients and in the aganglionic segment in 1. One patient died in the newborn period of overwhelming sepsis secondary to enterocolitis, and histology of the bowel confirmed HD. In 6 patients HD was confirmed on barium enema and suction rectal biopsy, and they subsequently underwent a definitive pull-through operation. The 1 patient in whom the initial barium enema was normal continued to suffer from constipation until the age of 7 years, when the diagnosis of HD was established. He then underwent a pull-through procedure with no further problems. An association between neonatal intestinal perforation and HD must therefore be recognised to avoid delay in the management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179451
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of hyperoxia on surfactant protein gene expression in hypoplastic lung in nitrofen-induced diaphragmatic hernia in rats (2000)
    Springer
    Pediatric surgery international 16 (2000), S. 473-477 
    Details
    ISSN: 1437-9813
    Keywords: Key words Congenital diaphragmatic hernia (CDH) ; Surfactant-associated protein ; Hypoplastic lung ; Ventilation ; Oxygen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The hypoplastic lung in congenital diaphragmatic hernia (CDH) has both a quantitative and qualitative reduction in surfactant. Recently, the role of oxygen (O2) as a regulator of pulmonary surfactant-associated protein (SP) gene expression has been reported. The mRNA level of SP has been demonstrated to be increased in the lungs of animals exposed to hyperoxia. The aim of this study was to investigate SP mRNA expression in hypoplastic CDH lung in rats during mechanical ventilation in order to determine the effect of O2 on SP synthesis in CDH. A CDH model was induced in pregnant rats following administration of nitrofen. The newborn rats with CDH and controls were intubated and ventilated. Ventilation was continued for 6 h under 100% oxygen. Reverse-transcription polymerase chain reaction (RT-PCR) was performed to evaluate the relative amounts of mRNA expression of SP-A, SP-B, SP-C, and SP-D. Relative amounts of SP-A, SP-B, and SP-D mRNA expression in CDH lung were significantly decreased compared to controls at birth and 6 h after ventilation. There was no significant difference in SP-C mRNA expression between CDH animals and controls. Upregulated mRNA expression of SP-A, SP-B, and SP-D in lungs of control animals at 6 h after ventilation suggests that oxygenation accelerates postnatal SP synthesis in normal lungs. The inability of O2 to increase SP mRNA expression in hypoplastic CDH lung suggests that the hypoplastic lung is not responsive to increased oxygenation for the synthesis of SP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003830000427
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  • 8
    Electronic Resource
    Electronic Resource
    The hypoplastic heart in congenital diaphragmatic hernia: reduced expression of basic fibroblast growth factor and platelet-derived growth factor (2000)
    Springer
    Pediatric surgery international 16 (2000), S. 243-246 
    Details
    ISSN: 1437-9813
    Keywords: Key words CDH ; Heart ; Basic fibroblast growth factor ; Platelet-derived growth factor ; Polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Newborn infants with congenital diaphragmatic hernia (CDH) still have high mortality. Recently, the possible role of a cardiac maldevelopment in the high mortality has been suggested. Human and animal studies have demonstrated that heart weight is significantly reduced in the presence of CDH. Basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) are pleiotropic regulatory peptides that are expressed in myocardium in precise developmental and spatial programs. PDGF and bFGF both stimulate cardiac growth by inducing cell proliferation and stimulating the synthesis of extracellular matrix. The aim of this study was to investigate the presence of heart hypoplasia in nitrofen-induced CDH in rats and the role of specific tissue growth factors (bFGF and PDGF) in its genesis. CDH was induced in pregnant rats following administration of 100 mg nitrofen on day 9.5 of gestation (term 22 days). In control animals the same dose of olive oil was given without nitrofen. Cesarean section was performed on day 21 of gestation. The fetuses were divided in two groups: normal controls (n = 8) and nitrofen-induced CDH (n = 8). Total RNA, DNA, and soluble proteins were extracted from the heart in each group and measured. mRNA was extracted from total RNA and a reverse transcription-polymerase chain reaction (RT-PCR) was performed to evaluate mRNA expression of bFGF and PDGF. The heart/body weight ratio (HBWR) and DNA content were significantly decreased (P 〈 0.01) in CDH animals compared to controls. RNA and protein content were also reduced in CDH. The expression of bFGF and PDGF mRNA was significantly reduced in the CDH group compared to controls (P 〈 0.01). The decreased HBWR, DNA, RNA, and protein content in the CDH heart indicates that the heart is hypoplastic in nitrofen-induced left CDH. The downregulation of bFGF and PDGF gene expression in the CDH heart suggests that these regulating peptides may play an important role in the genesis of cardiac hypoplasia in CDH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003830050737
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  • 9
    Electronic Resource
    Electronic Resource
    Antenatal dexamethasone improves atrial natriuretic peptide receptors in hypoplastic lung in nitrofen-induced diaphragmatic hernia in rats (2000)
    Springer
    Pediatric surgery international 16 (2000), S. 252-255 
    Details
    ISSN: 1437-9813
    Keywords: Key words Atrial natriuretic peptide ; Congenital diaphragmatic hernia ; Hypoplastic lung ; Reverse transcription polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Atrial natriuretic peptide (ANP) plays a major role in electrolyte and volume homeostasis through potent biological effects including vasorelaxation, bronchorelaxation, lung permeability, and clearance. There are two distinct biochemical and functional classes of ANP receptors, guanylate cyclase receptor (GC-R) and clearance receptors (clearance-R). Two subtypes of GC-R have been described, GCA-R and GCB-R. Antenatal glucocorticoid therapy (AGT) has been demonstrated to improve pulmonary immaturity and abnormal structure of pulmonary arteries in animal models of congenital diaphragmatic hernia (CDH). The aim of this study was to investigate the effect of antenatal glucocorticoid administration on the ANP system in nitrofen-induced CDH hypoplastic lung in rats. A CDH model was induced in pregnant rats following administration of nitrofen on day 9.5 of gestation. Dexamethasone (Dex) was given intraperitoneally on days 18.5 and 19.5; cesarean section was performed on day 21. Reverse transcription polymerase chain reaction was performed to evaluate the relative amounts of GCA-R, GCB-R and clearance-R mRNA expression. The mRNA expression of GCA-R, GCB-R, and clearance-R was significantly increased in CDH compared to control lung. ANP receptor mRNA expression was significantly decreased in CDH lung with compared to without Dex treatment. Our finding of increased ANP receptor mRNA expression in CDH lung suggests that the hypoplastic lung has high sensitivity for ANP. Decreased mRNA expression of ANP receptors in CDH lung after Dex treatment suggests that AGT may improve pulmonary physiological function of ANP in hypoplastic CDH lung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003830050739
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  • 10
    Electronic Resource
    Electronic Resource
    Muscarinic acetylcholine receptor expression in aganglionic bowel (2000)
    Springer
    Pediatric surgery international 16 (2000), S. 267-271 
    Details
    ISSN: 1437-9813
    Keywords: Key words Hirschsprung's disease ; Acetylcholine ; Muscarinic receptor ; mRNA ; Immunohistochemisty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In Hirschsprung's disease (HD) there exists an overabundance of acetylcholine (ACh), which in turn stimulates excessive production of the enzyme acetylcholinesterase. Muscarinic ACh receptors (mAChRs) play an important role in smooth-muscle contraction. Recent studies have indicated five different subtypes of mAChRs encoded by five different genes, m1 to m5. The purpose of this study was to investigate the expression of each mAChR subtype in aganglionic (AG) colon to further understand the pathophysiology of HD. Entire colon resected at the time of pull-through operation for HD was obtained from 14 patients. Specimens obtained at autopsy from 8 age-matched patients without gastrointestinal disease acted as controls. Frozen sections were used for indirect immunohistochemistry as well as in-situ hybridization. Immunohistochemistry was performed using specific antiserum against each mAChR subtype and in-situ hybridization was performed using specific oligonucleotide probes against m1 to m5 subtypes. Messenger RNA (mRNA) was extracted from normoganglionic (NG) and AG bowel of HD patients and normal control bowel. Reverse transcription-polymerase chain reaction was performed to evaluate mRNA levels of each mAChR subtype. To adjust the levels of mRNA expression, a housekeeping gene G3PDH, known to be expressed normally, was used as an internal control. Strong m2 and m3 immunoreactivity was observed in the mucosal layer, smooth-muscle layers, and myenteric plexus of NG bowel, whereas m1 immunoreactivity was only detected in the mucosal layer. The most striking finding was the abundance of m3-immunoreactive fibers in muscle layers of NG bowel while there was a total lack of m3 fibers in smooth-muscle of AG bowel. Intense mRNA signals encoding m2 and m3 and to a lesser degree m1 were detected in NG bowel, and these signals were weak in AG bowel. Immunoreactivity and mRNA expression of m4 and m5 was not detected in NG or AG bowel. The lack of m3-immunoreactive fibers in the smooth-muscle layers of AG bowel and decreased m2 and m3 mRNA expression in AG bowel may be responsible for the motility dysfunction in the aganglionic segment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003830050742
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