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  • 2000-2004  (3)
  • 1990-1994  (2)
  • 1955-1959  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Shock on T Versus Direct Current Voltage for Induction of Ventricular Fibrillation: (2004)
    350 Main Street , Malden , MA 02148-5018 , USA and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Futura Publishing, Inc.
    Pacing and clinical electrophysiology 27 (2004), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: VF is induced during ICD implantation to determine efficacy of therapy. Establishing the best clinical method of induction of VF would potentially be beneficial in reducing the number of induction attempts and reducing the frequency of inadvertent induction of VT. Commonly used methods to induce VF include shock in the T wave vulnerable period (T shock) and high frequency stimulation. This study compared the efficacy of T shock with a new induction method using a 9-V DC pulse. The study was a randomized, prospective, case crossover trial in patients receiving ICDs. VF was induced by T shock and DC in a randomized sequence during an ICD implant. VF was induced at least four times in each patient (two T shocks and two DC inductions) and with each induction; attempts were continued with modifications until successful. A paired evaluation between the T shock/DC induction was performed in 37 patients (28 men, age 64 ± 12 years) with a left ventricular ejection fraction of 0.40 ± 0.20. Arrhythmia indications were VT (n = 23), VF (n = 10), and VT/VF (n = 4). Drug therapy included amiodarone (n = 10), metoprolol (n = 6), digoxin (n = 1), and lidocaine (n = 1). The average T shock voltage was 207.0 ± 16.1 V. The S1 cycle drive length was consistently 400 ms, and the mean S2 coupling interval was 317.8 ± 19.6 ms. The length of time DC applied averaged 3.8 ± 1.4 seconds. A total of 148 episodes of VF were included in the analysis. T shock induced VF with a cycle length of 213.5 ± 35.1 ms, and DC induced VF with a cycle length of 214.6 ± 34.5 ms (P = 0.86). Although VF was eventually induced for each randomization, the number of attempts required were dependent on the method of induction. The successful DC first attempt VF induction rate was 96%, with three patients requiring two attempts during one of the DC inductions. T shock had a 68% first attempt success rate with 21 patients requiring multiple T shocks to induce VF. All nine female patients had at least one unsuccessful first attempt T shock, which contributed to an overall unsuccessful first attempt induction rate significantly higher in women then men (36.1% vs 12.5%, P = 0.001). A constant DC voltage induction of VF may be more effective than T shock for induction of VF in a clinical setting because it reduces the number of attempts required to induce VF. By either method, VF appears to be more difficult to induce in women. DC induction has the advantage of simple programming of only duration of stimulation. These findings have implications particularly for ICD implantation with conscious sedation. (PACE 2004; 27:89–94)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8159.2004.00391.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    One-electron oxidation of methoxylated and hydroxylated indoles by azide. 1. Characterization of the primary indolic radicals (1990)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 94 (1990), S. 6666-6670 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100380a028
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    Paper (German National Licenses)
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  • 3
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    Unknown
    THE HEIKE STORY, by Eiji Yoshikawa (Book Review) (1958)
    Honolulu, etc. : Periodicals Archive Online (PAO)
    Pacific Affairs. 31:3 (1958:Sept.) 308 
    Details
    ISSN: 0030-851X
    Topics: Political Science , Sociology , Economics
    Notes: BOOKS REVIEWED IN THIS NUMBER
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5082-1958-031-03-000010
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  • 4
    Electronic Resource
    Electronic Resource
    Artemisinins target the SERCA of Plasmodium falciparum (2003)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 424 (2003), S. 957-961 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Artemisinins are extracted from sweet wormwood (Artemisia annua) and are the most potent antimalarials available, rapidly killing all asexual stages of Plasmodium falciparum. Artemisinins are sesquiterpene lactones widely used to treat multidrug-resistant malaria, a disease that annually claims ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature01813
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Aging in the hypothalamo-neurohypophysial-renal system (1993)
    Springer
    Geriatric nephrology and urology 3 (1993), S. 93-106 
    Details
    ISSN: 1573-7306
    Keywords: aging ; hypothalamus ; neurohypophysis ; kidney ; arginine vasopressin ; morphology ; physiology ; review
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This review examines the age-changes in the hypothalamo-neurohypophysial-renal system (HNRS) and their role in age-associated alterations in the regulation of water homeostasis. A comparative approach has been adopted. The structural characteristics of the magnocellular nuclei are well preserved and there is no evidence for a significant loss of neurons from this region. Studies of the release of anti-diuretic hormone from the neurohypophysis are contradictory. In rodents there is a decline in neuroaxonal transport of hormone from the hypothalamus to the neurohypophysis. It is concluded that for most purposes the ability to respond to acute changes in plasma osmolality are preserved in rodents and humans. There is little evidence to suggest an alteration in the pharmacokinetics of anti-diuretic hormone with advancing age. The renal medullary collecting ducts of rodents, and possibly humans, show a reduced sensitivity to hormonal stimulation. However the complexities of kidney regulation, regarding changes in blood flow, medullary osmotic gradients, and so forth, have barely been investigated. The review indicates the complexity of the age-associated changes that can be found between, and within, species in the HNRS. Whatever the explanation for the differences between species clearly there is a decline in function with time. This results in micro-environmental changes within the older organism that in turn will influence the efficiency and accuracy of other metabolic processes controlling homeostasis and the functions of other systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01509278
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Neurotrophin receptors and nerve growth factor are differentially expressed in adjacent nonneuronal cells of normal and injured tooth pulp (2000)
    Springer
    Cell & tissue research 299 (2000), S. 225-236 
    Details
    ISSN: 1432-0878
    Keywords: trkA p75 Odontoblast Fibroblast Inflammation Leukocyte Polymorphonuclear leukocytes Rat (Sprague Dawley)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. High-affinity tyrosine kinase A (trkA) neurotrophin receptors on neurons and nonneuronal cells elicit differentiation or survival functions in response to nerve growth factor (NGF), whereas the low-affinity neurotrophin (p75) receptor modulates trkA activity or can independently cause apoptosis or NFκB-mediated survival functions. We examined dental tissues for the presence of trkA-like immunoreactivity (trkA-IR), to determine which nonneuronal cell types express it in normal compared with inflamed teeth and how the trkA-positive cells relate to those expressing the p75 receptor and/or NGF. Normal and injured rat molars (dentin cavity for 4 h, 16–24 h, 3 days, 16 days, or 5 weeks) were immunoreacted using the ABC detection system for two anti-trkA antibodies (sTA, Santa Cruz Biotechnology; rTA, L. Reichardt) and antibodies against p75 and NGF, all of which also stained pulpal nerve fibers. We report that, when using the sTA antibody (recognizing the intracellular carboxy terminal), nonneuronal trkA-IR was found in odontoblasts of normal teeth and also in invading polymorphonuclear leukocytes (PMNs) and reparative odontoblasts after injury. When using rTA (recognizing the extracellular domain of the receptor), nonneuronal trkA-IR was only found in odontoblasts. Odontoblasts also had NGF-IR but did not label for NGF mRNA. The lack of odontoblast NGF mRNA suggests that NGF is passed from fibroblasts to the adjacent odontoblasts, where it is picked up by receptor-mediated mechanisms for regulation of odontoblast function. Tooth injury disrupts this system such that trkA-IR decreases in injured odontoblasts, p75 decreases in fibroblasts, and NGF is upregulated by fibroblasts and accumulates in the injured pulp and surviving odontoblasts. Pulpal NGF may contribute to chemoattraction for the invading leukocytes or their sTA-IR may have been induced in response to pulpal NGF. Thus, tooth pulp has a different distribution of nonneuronal NGF and its paracrine receptors during inflammation compared with normal conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004419900129
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