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  • 2000-2004
  • 1990-1994  (2)
  • Biperiden  (1)
  • Hanche  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 111 (1993), S. 27-32 
    ISSN: 1432-2072
    Keywords: Pharmacokinetic ; Pharmacodynamic ; Interaction ; Remoxipride ; Biperiden
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twelve healthy male volunteers took part in a double-blind randomised cross-over study composed of three treatment sessions: remoxipride 100 mg; remoxipride 100 mg plus biperiden 4 mg; and biperiden 4 mg. Plasma and urine concentrations of remoxipride and biperiden, plasma prolactin levels, salivary flow and adverse events were recorded to assess pharmacodynamic interactions. Remoxipride and biperiden had no effect on each other's plasma concentrations. Biperiden did not affect the urinary recovery or renal clearance of remoxipride. Prolactin levels were unaffected by biperiden but increased following remoxipride administration. Differences in prolactin Cmax and tmax following remoxipride versus concomitant (remoxipride + biperiden) treatment were not statistically significant. However, a slight but statistically significant (P=0.04) increase in prolactin AUC was observed after concomitant treatment. No significant differences could be observed between the recorded salivary flow in all the treatment sessions. Single doses of remoxipride and biperiden showed no pharmacokinetic or pharmacodynamic interaction.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of orthopaedic surgery & traumatology 3 (1993), S. 313-315 
    ISSN: 1432-1068
    Keywords: Hanche ; Fracture ; Ostéosynthèse ; Infection ; Staphylocoques ; Hip ; Fracture ; Osteosynthesis ; Infection ; Staphylococci
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary During the last decade a decrease in postoperative infections in femoral neck fracture osteosynthesis was noted which led us to review all femoral neck fractures for infection. In a retrospective series of 1894 femoral neck fractures, the majority of which were included in other limited prospective studies, a total of 15 deep infections were diagnosed (0.8%). Staph. aureus was the most common bacterium cultured, and the diagnosis was established more than 4 months postoperatively in 9 of the patients. A total of 658 of the 1894 patients, who had pre- or peroperative tetracycline administration for measuring bone turnover, had two deep infections (0.3%). Among the remaining 1236 patients without antibiotic prophylaxis, 13 deep infections were diagnosed (1.0%). This difference suggests considering antibiotic prophylaxis in femoral neck fracture osteosynthesis. Eight of the infections led to THR, usually two-stage ; no signs of recurrent infection ensued, and the hip function of these patients was restored. The remaining 7 patients had Girdlestone procedures, also without recurrent infection, but with inferior functional outcome.
    Notes: Résumé On a noté pendant les dix dernières années une chute du nombre d'infections postopératoires dans les ostéosynthèses des fractures du col fémoral, ce qui nous a amené à revoir tous les cas infectés de ces fractures. Lors d'une série rétrospective de 1 894 fractures du col fémoral, dont la plupart étaient dans d'autres études prospectives limitées, on a diagnostiqué un total de 15 infections profondes (0,8 %). Le staphylocoque doré était la bactérie la plus souvent en cause ; le diagnostic était établi plus de 4 mois après l'intervention chez 9 des patients. 658 patients sur les 1 894, auxquels il avait été administré des tétracyclines per-opératoires pour mesurer le renouvellement osseux, ont présenté deux infections profondes (0,3 %). Parmi les 1 236 patients restants, sans antibioprophylaxie, on a comptabilisé 13 infections profondes (1,0 %). Cette différence incite à recommander la prophylaxie antibiotique dans l'ostéosynthèse de la fracture du col du fémur. Huit des infections ont conduit à une arthroplastie totale de la hanche, habituellement en deux étapes ; il n'y eut pas de récidive d'infection, et la fonction de la hanche fut rétablie chez ces patients. Les 7 patients restants ayant subi une résection de type Girdlestone, n'eurent aucune récidive d'infection, mais leur résultat fonctionnel fut moins bon.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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