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  • 2000-2004  (1)
  • 1990-1994  (1)
  • 1
    ISSN: 1432-2013
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Whole cell currents were recorded in single myocytes dissociated from guinea-pig ventricles, and caged compounds were loaded intracellularly through the patch electrodes. Flash photolysis of caged cyclic GMP (cGMP) increased the amplitudes of both catecholamine-induced Cl− (ICl) and Ca2+ currents (ICa) which were pre-activated by submaximum doses of isoprenaline. Transient activation of ICl by photo-release of cyclic AMP (cAMP) showed a half decay time (t1/2) of 16.7±1.4 sec (mean±S.E.M., n=14). This decay was markedly delayed by inhibiting phosphodiesterases using 3-isobutyl-1-methyl-xanthine (IBMX). The intracellular application of cGMP (10–50μ M)also prolonged the decay of the ICl response to caged cAMP (t1/2=38.0±7.1 sec, n=12). These findings strongly support the hypothesis that cGMP facilitates theβ-adrenergic response of ionic currents through the inhibition of phosphodiesterase in mammalian cardiac myocytes.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International journal of fracture 105 (2000), S. 49-56 
    ISSN: 1573-2673
    Keywords: Transversely isotropic piezoelectric material ; general solution ; potential of a simple layer ; penny-shaped crack.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract This paper reconsiders the problem of a penny-shaped crack in a piezoelectric medium under uniform mechanical as well as electric loadings applied at infinity (mode I). The analysis is based on the general solution of three-dimensional piezoelasticity, which is represented by four quasi-harmonic displacement functions. It is shown that these harmonics can be expressed in terms of two potentials of a simple layer. By using the previous results in potential theory, exact solution of the mode I crack is obtained. In particular, the solution is complete and in terms of elementary functions.
    Type of Medium: Electronic Resource
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