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  • 2000-2004  (3)
  • 1985-1989  (1)
  • Complement component 9 (C9)  (1)
  • Culex pipiens fatigans  (1)
  • Medical factors  (1)
  • Rheumatoid arthritis  (1)
  • Gliostatin
Source
Material
Years
  • 2000-2004  (3)
  • 1985-1989  (1)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Synovial inflammation and hyperplasia induced by gliostatin/platelet-derived endothelial cell growth factor in rabbit knees (2000)
    Springer
    Rheumatology international 20 (2000), S. 13-19 
    Details
    ISSN: 1437-160X
    Keywords: Key words Gliostatin ; Thymidine phosphorylase ; Platelet-derived endothelial cell growth factor ; Rheumatoid arthritis ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neovascularization, proliferation of synovial cells, and mononuclear cell influx and activation are characteristic events observed in synovial joints in the pathohistology of rheumatoid arthritis (RA). The objective of this study was to examine synovial inflammation in rabbit knees induced by intra-articular administration of human gliostatin/platelet-derived endothelial cell growth factor (GLS/PD-ECGF), which shares a high degree of chemical homology with thymidine phosphorylase (dThdPase) and is known to have angiogenic activity. Purified recombinant human gliostatin (rHuGLS) and its mutant protein, which was prepared by site-directed mutagenesis and which lacks dThdPase activity, were administered at various doses to rabbit knee joints. The effects of rHuGLS and the mutant were examined histologically. Intra-articular injection of rHuGLS resulted in the development of diffuse synovitis resembling RA. The mutant protein also brought about the same effect. These findings suggest that human GLS can cause RA-like synovitis in rabbit knee joints via a mechanism other than its dThdPase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002960000067
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Factors correlated with emotional instability in SLE outpatients (2000)
    Springer
    Modern rheumatology 10 (2000), S. 31-37 
    Details
    ISSN: 1439-7609
    Keywords: Key words Systemic lupus erythematosus ; Emotional instability ; Social factors ; Medical factors ; Physical factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eighty-four female outpatients with systemic lupus erythematosus (SLE) who are able to live on their own were investigated. We statistically analyzed the relationship between emotional instability based on psychological tests (Cornell Medical Index), and physical, medical, and social factors based on both our clinical records and original questionnaires. The emotional instability was related to not "working," an older "age at the time of SLE diagnosis," being "anxious about the adverse effects of steroids," or not "understanding the details of the disease and treatment at the time SLE treatment was started." No relationship with previously experienced physical factors was observed. In addition, no relationship with disease activity was observed either. We identified the characteristic correlation between emotional instability and medical and social factors in this study. Paying close attention to these factors may thus be useful in both preventing the appearance of psychological problems and developing effective early treatment strategies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101650070036
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Behçet's disease associated with complement component 9 (C9) deficiency (2000)
    Springer
    Modern rheumatology 10 (2000), S. 276-278 
    Details
    ISSN: 1439-7609
    Keywords: Key words Behçet's disease ; Complement component 9 (C9) ; Complement deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Behçet's disease is a multisystem inflammatory disorder with unknown etiology. It has been shown that the titer of plasma complement component 9 (C9) is a good indicator of the disease activity. Therefore, the involvement of C9 in the pathogenesis of Behçet's disease has been suggested. We report a case of Behçet's disease associated with complete C9 deficiency (C9D) carrying the homozygous nonsense mutation at Arg-95 of C9 (R95X). The patient presented the typical characteristics of Behçet's disease, such as uveitis, recurrent oral aphthae and genital ulcers, and arthritis, suggesting that C9 does not play an essential role in the pathogenesis of Behçet's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101650070017
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Absolute configuration of mosquito oviposition attractant pheromone, 6-acetoxy-5-hexadecanolide (1985)
    Springer
    Journal of chemical ecology 11 (1985), S. 643-648 
    Details
    ISSN: 1573-1561
    Keywords: Mosquito ; Culex pipiens fatigans ; Diptera ; Culicidae ; oviposition ; attractant ; pheromone ; chiral chromatography ; acetoxyhexadecanolide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract 6-Acetoxy-5-hexadecanolide (Ia) in the oviposition attractant pheromone released from egg apical droplets of the mosquitoCulex pipiens fatigans Wied. is shown to be the (−)-(5R,6S)- enantiomer. Identification was by chromatography of the 6-trifluoroacetoxy derivatives of the natural pheromone and of the synthetic (−)-(5R,6S)- (Ib) and (+)-(5S,6R)- (IIb) enantiomers on a capillary column having a chiral stationary phase comprising a derivative of (1S,3S)-chrysanthemic acid. The synthetic (−)-(5R,6S)- enantiomer (Ia) attracted oviposition of four fold more mosquito egg rafts than the control (P 〈 0.01) whereas for the (5S,6R)- enantiomer (IIa) there was no statistically significant oviposition attraction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00988573
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    Paper (German National Licenses)
    Fulltext
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