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  • 1
    Electronic Resource
    Electronic Resource
    Increased platelet thromboxane receptor sensitivity in diabetic patients with proliferative retinopathy (1986)
    Springer
    Diabetologia 29 (1986), S. 471-474 
    Details
    ISSN: 1432-0428
    Keywords: Platelets ; thromboxane sensitivity ; cAMP ; proliferative retinopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Platelet aggregation to collagen in 12 Type 1 (insulin-dependent) diabetic patients with background retinopathy and 12 Type 1 diabetic patients with proliferative retinopathy was compared with an age- and sex-matched control group. An analogue of prostaglandin H2, 11,9 epoxymethano-prostaglandin H2, which directly stimulates thromboxane receptors, and EP 092, which is a competitive thromboxane A2 receptor antagonist, were used to investigate changes at platelet thromboxane receptor level in these groups. The concentration of collagen (EC50) required to give 50% of maximum aggregation did not differ between the two diabetic groups and the control group. However, platelets from the proliferative retinopathy group were significantly more sensitive to the thromboxane mimetic (11,9 epoxymethano-prostaglandin H2) (p 〈 0.005) than the background retinopathy and control groups. This change may be a factor in the development of proliferative retinopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00453495
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Fluid requirements of patients with burns and inhalation injuries in an intensive care unit (1989)
    Springer
    Intensive care medicine 15 (1989), S. 464-466 
    Details
    ISSN: 1432-1238
    Keywords: Burns ; Inhalation injury ; Resuscitation ; Fluid Replacement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have studied 9 patients with burns (20%–75%) who had inhalation injuries and compared their actual fluid requirements with their requirements calculated from the Muir and Barclay formula. All patients were resuscitated with plasma protein fraction at a rate sufficient to keep their physiological variables within the following range: heart rate 〈120/min, central venous pressure 8–12 cm H2O, urine output 〉30–50 ml/h, systolic blood pressure 〉90 mm Hg and diastolic blood pressure 〉60 mm Hg. The amount of plasma protein fraction needed was 4.38±1.26 ml/kg/% burn in the first 24 h and 2.15±0.97 ml/kg/% burn in the second 24 h. This is an increase of 75% and 110% respectively above values predicted from the formula. We suggest that the observed difference is due to a combination of the presence of an inhalation injury which increases fluid requirements by approximately 30% in the first 24 h and the use of plasma protein fraction rather than the dried plasma used in the original Muir and Barclay formula.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00255603
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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