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Evaluation of effectiveness of chemotherapy in patients with gastric cancer after curative resection (2000)

Tsujinaka, T. ; Shiozaki, H. ; Inoue, M. ; [et al.]

Springer

International journal of clinical oncology 5 (2000), S. 372-379

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ISSN: 1437-7772

Keywords: Key words p53 ; Gastric cancer ; Adjuvant chemotherapy ; Randomized study

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Background. A prospective randomized study involving gastric cancer patients was undertaken to evaluate combined adjuvant chemotherapy and the prognostic value of biologic markers. Methods. One hundred and eighty-five patients under 75 years of age who underwent a curable resection of pathologic stage II or III gastric cancer were randomly assigned to receive adjuvant chemotherapy containing either: mitomycin C (MMC) plus oral 5-fluorouracil (FU) (MF), epirubicin plus oral FU (EF), or oral FU (F). Tumor tissue collected at surgery was immunohistochemically analyzed for p53 and proliferating cell nuclear antigen, and DNA ploidy was determined. Results. All prognostic factors were equally distributed in each arm. There was no significant difference among the groups in the 5-year overall survival. When the relationship between the biologic markers and prognosis was analyzed, the overall survival of all patients and stage III patients was poorer in those with p53 positivity, but the difference did not achieve significance. For patients with positive nodes, irrespective of the treatment regimen, p53-positivity was significantly associated with poorer prognosis (P = 0.05). In stage III patients, the survival of those with p53-positivity and DNA aneuploidy was significantly worse than that for patients with any other combination (P = 0.02). Conclusion. No survival benefit was observed with the combined chemotherapeutic regimens compared with FU alone. p53 positivity was negatively correlated to survival for node-positive and stage III patients.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/PL00012066

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Growth rate and mitotic index analysis of Vicia faba L. Roots exposed to 60-Hz electric fields (1985)

Inoue, M. ; Miller, Morton W. ; Cox, Christopher ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Bioelectromagnetics 6 (1985), S. 293-303

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ISSN: 0197-8462

Keywords: plant roots ; 60-Hz electric fields ; mitotic index ; Vicia faba L ; growth rate ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Physics

Notes: Growth, mitotic index, and growth rate recovery were determined for Vicia faba L. roots exposed to 60-Hz electric fields of 200, 290, and 360 V/m in an aqueous inorganic nutrient medium (conductivity 0.07-0.09 S/m). Root growth rate decreased in proportion to the increasing strength; the electric field threshold for a growth rate effect was about 230 V/m. The induced transmembrane potential at the threshold exposure was about 4-7 mV. The mitotic index was not affected by an electric field exposure sufficient to reduce root growth rate to about 35% of control. Root growth rate recovery from 31-96% of control occurred in 4 days after cessation of the 360 V/m exposure. The results support the postulate that the site of action of the applied electric fields is the cell membrane.

Additional Material: 5 Ill.