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  • 1
    Electronic Resource
    Electronic Resource
    A randomised controlled trial of cytological surveillance versus patient choice between surveillance and colposcopy in managing mildly abnormal cervical smears (2004)
    Oxford, UK and Malden, USA : Blackwell Science Ltd
    BJOG 111 (2004), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective  To determine whether choice of colposcopy or six month cytological surveillance would be beneficial to women with mildly abnormal smears when compared with the national policy of six months surveillance in terms of psychological morbidity.Design  A randomised trial based on the Zelen design.Setting  A hospital-based research clinic.Population  Four hundred and seventy-six women who had had a recurrent borderline or mildly dyskaryotic smear on routine cervical screening in primary care.Methods  Women were randomised either to six months cytological surveillance or to make a choice between that or colposcopy and were followed up for 1 year.Main outcome measures  The primary outcome measure was caseness (score ≥4) on the General Health Questionnaire at 12 months follow up. Other measures were the Spielberger State and Trait scores, default rates and cytology/colposcopy outcomes.Results  There was no significant difference between the arms for General Health Questionnaire (GHQ) scores and Spielberger State and Trait at 12 months. There was a significant reduction in psychometric morbidity between baseline and 12 months in both arms. Overall rates of default from the protocol were the same in both arms, but default that led to uncertain ascertainment of cervical pathology was greater in the no-choice arm.Conclusions  This trial indicates that having choice did not impact favourably or harmfully on anxiety or feelings of wellbeing. If a patient is anxious, allowing the patient to choose immediate colposcopy may be preferable because it will improve ascertainment of underlying disease in a group who are more likely to default.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-0528.2003.00007.x
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  • 2
    Electronic Resource
    Electronic Resource
    Prenatal Exposure to Alcohol Modifies Central Opioid Analgesia Systems in the Rat (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 467 (1986), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1986.tb14649.x
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  • 3
    Electronic Resource
    Electronic Resource
    Hamiltonization for singular and nonsingular mechanics (1987)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 28 (1987), S. 807-809 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: A Hamiltonization procedure valid for both singular and nonsingular mechanics is proposed. A comparison with Dirac's theory (for singular systems) is developed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.527622
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  • 4
    Electronic Resource
    Electronic Resource
    Determination of nitrogen-15 enrichment of nitrate and nitrite using thermospray liquid chromatography-mass spectrometry (1986)
    s.l. : American Chemical Society
    Analytical chemistry 58 (1986), S. 2782-2784 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00126a043
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  • 5
    Electronic Resource
    Electronic Resource
    Linearization of the Hamilton–Jacobi equation (1986)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 27 (1986), S. 1754-1755 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: Through a canonoid transformation the integration for the Hamilton–Jacobi equations is transformed into a two step procedure: the first being a linear problem and the second a quasilinear one. Examples are given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.527040
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  • 6
    Electronic Resource
    Electronic Resource
    On the generation of equivalent Hamiltonians (1986)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 27 (1986), S. 151-152 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: A new approach to the equivalence problem (in phase space) is presented. Given a Hamiltonian describing a system of particles with two degrees of freedom (and the corresponding Hamilton–Jacobi equation), it is shown how to find the most general family of Hamiltonian functions that generates a new Hamilton–Jacobi equation with the following (and essential) characteristic, here defined as equivalence: Every new solution is also a solution of the original Hamilton–Jacobi equation and vice versa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.527382
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  • 7
    Electronic Resource
    Electronic Resource
    Thromboxane A2 receptor gene polymorphism is associated with the serum concentration of cat-specific immunoglobulin E as well as the development and severity of asthma in Chinese children (2002)
    Copenhagen, Denmark : Munksgaard International Publishers
    Pediatric allergy and immunology 13 (2002), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thromboxane A2 and its receptor (TBXA2R) are involved in the constriction of vascular and respiratory smooth muscles. The T924C polymorphism in the TBXA2R gene was recently found to be associated with asthma in Japanese adults but not in children. Its relationship with atopy or asthma severity in children has not been defined. To investigate this further, we first assessed the severity of asthma in Chinese children using a standardized questionnaire modified from the Disease Severity Score and spirometric evaluation. Then, peripheral blood was analyzed for serum total and aeroallergen-specific immunoglobulin E (IgE) levels, and TBXA2R T924C genotypes were determined by restriction fragment length polymorphism (RFLP) analysis. One-hundred and fifty three asthmatic patients and 57 control children were recruited, of respective mean ages 9.9 and 11.0 years (p = 0.07). The mean logarithmic serum total IgE concentration was 2.57 and 2.09, respectively, for the asthmatic group and control group (p 〈 0.0001). Atopy was detected in 132 (86%) asthmatics and 33 (58%) controls. A significant association was observed between T924C and the diagnosis of atopic asthma (p = 0.044; odds ratio: 1.84). In addition, those asthmatics homozygous for the mutant allele in T924C had a lower forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) (p = 0.032 and 0.002, respectively). Among our asthmatic patients, the TBXA2R T924C polymorphism correlated with the concentration of cat-specific IgE in serum (p = 0.046). Nonetheless, this gene marker did not show an association with the serum total IgE concentration or any clinical indicator of asthma severity. In conclusion, our results suggest that the T924C marker in the TBXA2R gene is associated, in Chinese children, with an increased susceptibility of developing atopic asthma. This marker is also associated with the extent of allergic sensitization to cat, as well as with reduced FEV1 and FVC values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1399-3038.2002.01033.x
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  • 8
    Electronic Resource
    Electronic Resource
    The C−159T polymorphism in the CD14 promoter is associated with serum total IgE concentration in atopic Chinese children (2003)
    Oxford, UK : Munksgaard International Publishers
    Pediatric allergy and immunology 14 (2003), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Activation of macrophages through CD14 by microbes is crucial in inducing immunity by type 1 T helper cells. A C-to-T polymorphism at position −159 of CD14 was associated with serum total IgE level in Caucasians but not in Japanese subjects. The objective of this study is to determine whether this polymorphic marker is associated with atopy and asthma phenotypes in Chinese children. Restriction fragment length polymorphism was used to characterize CD14/−159 genotypes. Microparticle immunoassay was used to measure serum total IgE level; fluorescent enzyme immunoassay was performed to measure serum concentrations of specific IgE to aeroallergens; and enzyme-linked immunosorbent assay was used to measure serum levels of soluble CD14 (sCD14). Lung function in asthmatics was assessed by spirometry. Two hundred and fifty-eight patients and 92 control children were recruited. Their mean serum total IgE concentrations were 331 and 74 kIU/l, respectively (p 〈 0.0001). Atopy, defined as the presence of at least one allergen-specific IgE in serum, was found in 220 (85%) patients and in 41 (45%) controls (p 〈 0.0001). Serum sCD14 levels were significantly associated with CD14/−159 genotypes (p = 0.004). Atopic subjects with CC genotype in CD14/−159 had the highest serum total IgE levels compared with CT and TT genotypes, with the respective mean values being 661, 427 and 380 kIU/l (p = 0.015). Similarly, a higher proportion of subjects with CC genotype had increased serum total IgE concentration (p = 0.039). This polymorphic marker was not associated with asthma or aeroallergen sensitization in our cohort. Our results suggest that the C−159T of CD14 was associated with serum total IgE concentration in atopic Chinese children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1399-3038.2003.00048.x
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  • 9
    Electronic Resource
    Electronic Resource
    Human safety study of body lotion containing Kathon® CG (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 16 (1987), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The safety of Kathon® CG biocide as a preservative in leave-on body lotions was assessed by 2 double-blind studies, using similar protocols. A total of 209 healthy male and female subjects aged 18 to 65 years, 100 in California (72 test subjects, 28 controls) and 109 in Florida (88 test subjects, 21 controls) completed the studies which included pre- and post-use phase diagnostic patch testing with Kathon CG 100 ppm active ingredient, and 13 weeks daily applications of either a test lotion containing Kathon CG 15 ppm active ingredient or a control lotion without Kathon CG. No evidence of irritation or sensitization attributable to use of the biocide was found during regular dermatological examinations during the use phase. Post-use phase patch testing produced negative results in all subjects with the exception of 1 control subject in Florida who had positive readings at the 2- and 4-week post-use phase patch testing. Overall, these studies show there is minimal, if any, risk of adverse effects associated with the use of Kathon CG 15 ppm active ingredient in a leave-on application.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1987.tb01425.x
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  • 10
    Electronic Resource
    Electronic Resource
    Qualitative Nutritional Intake Analysis of Older Adults with Sjogren's Syndrome (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Gerodontology 7 (1988), S. 0 
    Details
    ISSN: 1741-2358
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Previous studies support certain nutritional inadequacies in the diets of older adults. Studies also identify xerostomia as a contributor to inadequate lubrication, mastication, taste and swallowing. Prior to this study a relationship between xerostomia and inadequate nutritional intake has not been documented. This study qualitatively analyzed the diets of older adults with Sjogren's Syndrome (SS); (n= 28; mean age = 69.1), A control group of age-sex-physical status matched seniors; (n= 24; mean age = 68.2) was also analyzed. The presence of xerostomia was confirmed by both clinical and sialometric techniques for alt subjects. Subjects were interviewed, completed a five-day diet record, and were interviewed again for quantitative analysis. The diets were then analyzed by computer for specific nutrient composition. The results indicated significant inadequacies at the p 〈 0.001 level for all the nutrients assessed in SS subject group as compared to both the controls and the RDAs. The significant differences were for: kilocalories, protein, fiber, potassium, vitamin A, vitamin C, vitamin B-6, thiamin, riboflavin, iron, calcium and zinc. The most striking inadequacies (〉 75% of all subjects) were for: fiber, vitamin B-6, potassium, calcium and zinc. These results support an association between geriatric malnutrition and xerostomia. This study provides an important foundation for future research in the area of xerostomia in the aged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1741-2358.1988.tb00306.x
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