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  • 2000-2004  (1)
  • 1980-1984  (3)
  • 1970-1974  (2)
  • 1925-1929
  • Analytical Chemistry and Spectroscopy  (4)
  • Biochemistry and Biotechnology  (1)
  • DNA Methylation  (1)
  • Head and Neck Squamous Cell Carcinoma  (1)
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Material
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  • 2000-2004  (1)
  • 1980-1984  (3)
  • 1970-1974  (2)
  • 1925-1929
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Inactivation of p16INK4a in Primary Tumors and Cell Lines of Head and Neck Squamous Cell Carcinoma (2000)
    Springer
    Molecules and cells 10 (2000), S. 557-565 
    Details
    ISSN: 0219-1032
    Keywords: DNA Methylation ; Head and Neck Squamous Cell Carcinoma ; p16INK4a
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Inactivation of the p16INK4a gene by mutation and deletion is common in head and neck squamous cell carcinoma (HNSCC). The present study demonstrates that hypermethylation of the 5′ CpG islands can serve as an alternative mechanism for the inactivation of the p16INK4a gene in this tumor. We studied 11 HNSCC cell lines and 17 oral squamous cell carcinoma (OSCC) primary tumors for p16INK4a gene status by protein/mRNA and DNA genetic/epigenetic analyses to determine the incidence of its inactivation. Our study indicates that: (1) inactivation of p16 protein is frequent in HNSCC cell lines (6/11, 54.5%) and OSCC primary tumors (15/17, 88.2%), (2) inactivation of p16INK4a protein is commonly associated with the presence of gene alteration such as mutation, homozygous deletion and especially aberrant methylation, and (3) genomic sequencing of bisulfite-modified DNA shows that the carcinoma develops a heterogeneous pattern of hypermethylation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s10059-000-0557-8
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effectiveness factor calculations for immobilized enzyme catalysts (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 15 (1973), S. 879-888 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The steady state, nonlinear diffusion equations which describe reactions in constrained enzyme solutions are of great interest in many biological and engineering applications. As in other types of nonlinear differential equations, exact analytical solutions do not exist except in some simplified cases. In this paper, a general procedure is presented for solving numerically for the substrate concentration profile and effectiveness factor utilizing the transformation method suggested by Na and Na. Design correlations for enzyme solutions constrained within spherical membranes are included. The use of a unique definition of the Thiele Modulus in these charts permits the clear illustration of the effects of substrate concentration and external mass transfer resistances on the overall effectiveness factor for the catalyst particle.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260150505
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of an atypical constitutent of a clandestine opiate (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 350-351 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An unusual morphine analog was extracted and separated from an opium-like sample. The high resolution mass spectrum of the unknown substance confirmed the empirical formula as C17H18O2NCl. Mass spectra and retention factor values in thin-layer chromatography of both unknown and authentic standards were compared, which lead to the identification of the unknown as β-chloromorphide.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010511
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Some calculations of solvent effects on 17O and 19F chemical shifts (1980)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 14 (1980), S. 92-97 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Sum-over-states perturbation and finite perturbation calculations, within the ‘Solvaton’ model, are presented for the variation of some 17O and 19F chemical shifts as a function of the dielectric constant of the medium. In general, the nuclear screening and charge are predicted to increase as the dielectric constant increases. The effects of hydrogen bonding are included by means of minimum energy dimer models in some of the sum-over-states calculations.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270140204
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Solvent effects on the nitrogen screening of some nitroalkanes (1981)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 16 (1981), S. 57-59 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: High precision 14N screening measurements are presented for some nitroalkanes. The screening increases as the dielectric constant of the solvent decreases in all cases considered. The β effect on the nitrogen screening is found to be largely independent of solvent, and is thus an intrinsic property of the nitroalkanes. Good agreement is obtained between the observed solvent effects on nitrogen screening and those calculated by the SOS procedure using INDO/S parameters. It is concluded that the measured nitrogen screening changes monitor the electronic changes which occur in the nitroalkanes as the medium is changed.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270160115
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  • 6
    Electronic Resource
    Electronic Resource
    Some INDO/S—SOS calculations of the effects of hydrogen bonding on the nitrogen shielding of some heterocycles (1983)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 21 (1983), S. 501-504 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Some INDO/S parameterized SOS shielding calculations are reported for the nitrogen nuclei of some N-heterocycles. Hydrogen bonding with H2O and CF3CH2OH is incorporated in a supermolecule approach. The calculated effects of hydrogen bonding are found to be in satisfactory agreement with observed nitrogen shielding variations upon a change of solvent.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/omr.1270210810
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    Paper (German National Licenses)
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