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  • 2000-2004  (1)
  • 1980-1984  (1)
  • 1955-1959  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Physicians' perceptions of possibilities and obstacles prior to implementing a computerised drug prescribing support system (2004)
    Bingley : Emerald
    International journal of health care quality assurance 17 (2004), S. 173-179 
    Details
    ISSN: 0952-6862
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Medicine , Economics
    Notes: Seeks to identify physicians' perceptions of possibilities and obstacles prior to implementing a computerised drug prescribing support system. Details a descriptive, qualitative study, with semi-structured individual interviews of 21 physicians in the Accident and Emergency Department of South Stockholm General Hospital. Identifies four descriptive categories for possibilities and obstacles. Concludes that gaining access to patient drug history enables physicians to carry out work in a professional way - a need the computerised prescription support system was not developed for and thus cannot fulfil. Alerts and producer-independent drug information are valuable in reducing workload. However, technical prerequisites form the base for a successful implementation. Time must be given to adapt to new ways of working.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09526860410541487
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Prenatal and neonatal drug metabolism in man (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 9-15 
    Details
    ISSN: 1432-1041
    Keywords: fetus ; neonate ; oxazepam ; pethidine ; acetaminophen (paracetamol) ; glucuronides ; sulfates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Drug oxidations are catalyzed by the liver microsomal fraction of human fetuses but not by fetal livers from most experimental animals. In contrast, glucuronidation of some substrates is catalyzed by the rat fetal liver in late gestation but not in the human fetal liver. The deficient human fetal glucuronidation seems to be compensated for by early development of sulfation activity. The inconsistency of the results from animal fetuses and human fetuses shows that animal data have little relevance for the human fetus. No generalized statements can be made about drug disposition in the newborn infant as compared to adults. Although most drugs that are oxidized have prolonged plasma half-lives in the neonatal period there are examples of drugs with half-lives similar to, or even shorter than, the average half-lives in adults. Oxazepam is conjugated with glucuronic acid in adults. The neonatal plasma half-life of this drug is considerably prolonged. This is true also for its conjugate as would be expected from the immature renal function in newborns. Adequate pharmacokinetic information is a prerequisite for rational and safe drug treatment in the neonatal period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561473
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Recrystallization of uranium by the action of cyclic heat-treatment (1958)
    Springer
    Atomic energy 4 (1958), S. 729-733 
    Details
    ISSN: 1573-8205
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Physics
    Notes: Abstract During cyclic heat-treatment in the temperature range 100–550 °C with cycles of 50 second duration, recrystallization resulting in a refinement of the original microstructure occurs in uranium quenched from the γ-phase region, as well as in uranium annealed in the γ-phase and in cast uranium, not subjected to additional deformation. Recrystallization commences at places with maximum distortion of the crystal lattice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01515400
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Formation of porosity in uranium under the action of thermal cycling (1957)
    Springer
    Atomic energy 2 (1957), S. 637-643 
    Details
    ISSN: 1573-8205
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Physics
    Notes: Abstract In accelerated thermal cycling with a cycle of 50 sec period, considerable changes appear in uranium after 50–1000 cycles, depending upon the temperature range of the cycle. Cycling in the temperature range of the α-phase (with heating up to between 550 and 600 °C) produces in texturcd uranium (containing about 0.1% carbon) a directional deformation and porosity, accompanied by a drop in density. After 5000 cycles, the drop in density amounts to 8% Thermal cycling with α = ß = γ-transformations produces a pronounced distortion of the original shape of uranium speclmens and intense porosity formation, with a considerable drop in density, which attains 30% after 1000 cycles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01514535
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    Paper (German National Licenses)
    Fulltext
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