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  • 2000-2004  (1)
  • 1980-1984  (1)
  • 1950-1954
  • 1915-1919
  • DRIS  (1)
  • Double-blind  (1)
  • Drug concentration  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 73 (1981), S. 77-80 
    ISSN: 1432-2072
    Keywords: Double-blind ; Sulpiride ; Haloperidol ; Chronic schizophrenia ; Drug concentration ; Prolactin level ; Clinical effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a double-blind study the therapeutic efficacy of sulpiride was compared to that of haloperidol — an established neuroleptic agent. A total of 30 female patients with a diagnosis of chronic schizophrenia were initially stabilised on the dosage of haloperidol which produced optimum therapeutic response when given once or twice daily. The patients were then randomly allocated to receive either sulpiride or haloperidol over a period of 12 weeks. Plasma drug concentrations and prolactin levels were determined. Clinical effects were evaluated by Brief Psychiatric Rating Scale (BPRS), Wing Rating Scale, and Extrapyramidal Symptoms Rating Scale (EPS). A standardised side-effects checklist was used. Treatment with sulpiride was associated with a significant rise in plasma prolactin level, but paradoxically these patients had significantly reduced extrapyramidal symptoms. No significant correlation was found between plasma sulpiride concentration and prolactin level or any of the clinical variables. The study confirms the antipsychotic activity of sulpiride.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-5036
    Keywords: basaltic soils ; DRIS ; perennial ryegrass ; phosphorus recommendations ; soil P test ; soil type
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Perennial ryegrass is the most important species of forage grass in both continental Europe and the British Isles. An investigation was carried out to see if the DRIS model developed for this species was able to diagnose crop nutrient sufficiency status, at harvest time, using data for herbage samples collected 2 weeks earlier. A re-evaluation of P fertiliser recommendations for silage, based on the ‘Olsen’ soil P-test, was then carried out using DRIS diagnoses of P sufficiency status as the criteria with which to judge if swards had been adequately, under, or over-supplied with fertiliser P. The results confirmed that reliable (DRIS) diagnoses of N, P, K and S sufficiency statuses of silage swards may be made from herbage clippings taken 2 weeks prior to harvest. Current P recommendations for silage swards proved to be excessive for non-basaltic sandy textured soils at first cut, correct for this group of soils at second cut, and more or less correct for non-basaltic clay textured soils at both cuts. For basaltic soils, however, P recommendations at both cuts appeared to be unrelated to plant P status, and it was concluded that the ‘Olsen’ soil P-test had provided an erroneous assessment of plant available P in these exceptionally iron-rich soils.
    Type of Medium: Electronic Resource
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