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In Vitro Metabolism of Fumonisin B1 by Ruminal Microflora (2000)

Caloni, F. ; Spotti, M. ; Auerbach, H. ; [et al.]

Springer

Veterinary research communications 24 (2000), S. 379-387

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ISSN: 1573-7446

Keywords: biodegradation ; fumonisin B1 ; metabolites ; microflora ; mycotoxin ; rumen ; short-chain fatty acid

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium moniliforme and F. proliferatum. Little is known of its metabolic fate after oral ingestion in ruminants, but these animals are reported to be tolerant towards FB1. The metabolism of this mycotoxin was evaluated following incubation (1 μg/ml) in ruminal fluid for up to 72 h, in the presence or absence of alfalfa as a substrate for microbial growth, using a model rumen (sealed flask, anaerobic conditions, exclusion of light, gentle agitation, 39°C). The decrease in FB1 concentration and the production of short-chain fatty acids were determined. FB1 had no effect on SCFA production. After 72 h incubation, FB1 depletion was 12% and 18% in samples with and without alfalfa, respectively. No hydrolysed metabolites (aminopolyols or aminopentol) were detected. These results indicate that FB1 is poorly metabolized in the rumen and suggest that such metabolism is not the cause of the tolerance to this toxin displayed by ruminants.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1006422200226

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Notizen zur Synthese von 2-Aminophenylsulfonen (1980)

Courtin, Alfred ; von Tobel, Hans-Rudolf ; Auerbach, Günther

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 63 (1980), S. 1412-1419

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ISSN: 0018-019X

Keywords: Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Syntheses of some Alkyl, Cycloalkyl and Aryl 2-Aminophenyl SulfonesSyntheses of the alkyl, cycloalkyl and aryl 2-aminophenyl sulfones 10 were achieved by oxidation of the corresponding 2-nitrophenyl sulfides 7 to the 2-nitrophenyl sulfones 9 followed by ethanolic Béchamp-reduction. The sulfides 7 in turn were obtained either by reactions of 2-nitro-thiophenol (8) with the appropriate alkyl and cycloalkyl halides or of 2-chloro-nitrobenzene (5) with the relevant thiols. Condensation of 2-nitrobenzenesulfinic acid (3) with bromoacetic acid in aqueous alkaline solution led - presumably via 2-nitrophenylsulfonylacetic acid (4) - to methyl 2 nitrophenyl sulfone (1), reduction of which gave 2-aminophenyl methyl sulfone (2). Treatment of 2-aminothiophenol (11) with t-butyl alcohol in aqueous sulfuric acid gave 2-aminophenyl t-butyl sulfide (12), which was acetylated to o-t-butylthio-acetanilide (13). Oxidation of the latter to o-t-butylsulfonyl-acetanilide (14) followed by hydrolysis led to 2-aminophenyl t-butyl sulfone (15).