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  • 2000-2004  (1)
  • 1980-1984  (1)
  • 1925-1929
  • Engineering General  (1)
  • Head and Neck Squamous Cell Carcinoma  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Optimal shape remodelling of linearly elastic plates using finite element methods (1984)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 20 (1984), S. 1823-1840 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The optimality conditions for the optimal shape remodelling of linearly elastic plates are obtained by introducing the total variation of a function defined on a variable domain, although the variation of a function has been taken on a fixed domain in most literature on calculus of variations. Using these optimality conditions, a solution scheme involving an iterative algorithm is proposed, together with several numerical examples.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620201006
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inactivation of p16INK4a in Primary Tumors and Cell Lines of Head and Neck Squamous Cell Carcinoma (2000)
    Springer
    Molecules and cells 10 (2000), S. 557-565 
    Details
    ISSN: 0219-1032
    Keywords: DNA Methylation ; Head and Neck Squamous Cell Carcinoma ; p16INK4a
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Inactivation of the p16INK4a gene by mutation and deletion is common in head and neck squamous cell carcinoma (HNSCC). The present study demonstrates that hypermethylation of the 5′ CpG islands can serve as an alternative mechanism for the inactivation of the p16INK4a gene in this tumor. We studied 11 HNSCC cell lines and 17 oral squamous cell carcinoma (OSCC) primary tumors for p16INK4a gene status by protein/mRNA and DNA genetic/epigenetic analyses to determine the incidence of its inactivation. Our study indicates that: (1) inactivation of p16 protein is frequent in HNSCC cell lines (6/11, 54.5%) and OSCC primary tumors (15/17, 88.2%), (2) inactivation of p16INK4a protein is commonly associated with the presence of gene alteration such as mutation, homozygous deletion and especially aberrant methylation, and (3) genomic sequencing of bisulfite-modified DNA shows that the carcinoma develops a heterogeneous pattern of hypermethylation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s10059-000-0557-8
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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