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  • 2000-2004  (1)
  • 1980-1984  (1)
  • 1890-1899
  • Clinical effects  (1)
  • Homosexuality  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A clinical and pharmacodynamic evaluation of sulpiride (1981)
    Springer
    Psychopharmacology 73 (1981), S. 77-80 
    Details
    ISSN: 1432-2072
    Keywords: Double-blind ; Sulpiride ; Haloperidol ; Chronic schizophrenia ; Drug concentration ; Prolactin level ; Clinical effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a double-blind study the therapeutic efficacy of sulpiride was compared to that of haloperidol — an established neuroleptic agent. A total of 30 female patients with a diagnosis of chronic schizophrenia were initially stabilised on the dosage of haloperidol which produced optimum therapeutic response when given once or twice daily. The patients were then randomly allocated to receive either sulpiride or haloperidol over a period of 12 weeks. Plasma drug concentrations and prolactin levels were determined. Clinical effects were evaluated by Brief Psychiatric Rating Scale (BPRS), Wing Rating Scale, and Extrapyramidal Symptoms Rating Scale (EPS). A standardised side-effects checklist was used. Treatment with sulpiride was associated with a significant rise in plasma prolactin level, but paradoxically these patients had significantly reduced extrapyramidal symptoms. No significant correlation was found between plasma sulpiride concentration and prolactin level or any of the clinical variables. The study confirms the antipsychotic activity of sulpiride.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431106
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Measurement Models for Sexual Orientation in a Community Twin Sample (2000)
    Springer
    Behavior genetics 30 (2000), S. 345-356 
    Details
    ISSN: 1573-3297
    Keywords: Homosexuality ; sexual orientation ; heritability ; twins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Multivariate structural equation modeling techniques have been applied to examine the causes of individual differences in responses to several items concerning sexual orientation. To minimize potential ascertainment and response biases, the study sample involved a large (N = 4901) community-based cohort of Australian twins aged 18–52 who answered an anonymous questionnaire on sexual behavior and attitudes. The statistical power of the analysis was increased by the availability of multiple measures of sexual orientation (behaviors, attitudes and feelings), providing stronger evidence for the existence of additive genetic influences on this phenotype than in a previous analysis (Bailey et al., 2000). Estimates of the heritability of homosexuality in this sample ranged between 50 and 60% in females but were significantly lower (heritability of approximately 30%) in males.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026557719181
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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