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Digitale Medien

Effect of 6-hydroxydopamine on in vitro hippocampal corticosterone binding capacity in the male rat (1983)

Weidenfeld, J. ; Siegel, R. A. ; Corcos, A. P. ; [weitere]

Springer

Experimental brain research 52 (1983), S. 121-124

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Details

ISSN: 1432-1106

Schlagwort(e): Hippocampus ; Corticosterone ; Nuclear binding ; 6-Hydroxydopamine ; Noradrenaline

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Adult male rats were injected with 6-hydroxydopamine, either into the lateral brain ventricle or directly into the dorsal hippocampus. They were adrenalectomized 5–7 days later, and following an additional 24 hours, the specific in vitro 3H- corticosterone binding capacity of dorsal hippocampal slices was determined by estimation of uptake of radioactivity by the nuclear fraction. Specific corticosterone binding was reduced by 40–50% in both experimental groups, as compared to vehicle-treated controls. These results suggest that the maintenance of normal dorsal hippocampal Corticosterone binding capacity is dependent upon the integrity of endogenous brain catecholaminergic neural systems.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00237156

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