ISSN:
1432-1106
Keywords:
Hippocampus
;
Corticosterone
;
Nuclear binding
;
6-Hydroxydopamine
;
Noradrenaline
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Adult male rats were injected with 6-hydroxydopamine, either into the lateral brain ventricle or directly into the dorsal hippocampus. They were adrenalectomized 5–7 days later, and following an additional 24 hours, the specific in vitro 3H- corticosterone binding capacity of dorsal hippocampal slices was determined by estimation of uptake of radioactivity by the nuclear fraction. Specific corticosterone binding was reduced by 40–50% in both experimental groups, as compared to vehicle-treated controls. These results suggest that the maintenance of normal dorsal hippocampal Corticosterone binding capacity is dependent upon the integrity of endogenous brain catecholaminergic neural systems.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00237156
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