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  • 2000-2004
  • 1980-1984  (3)
  • Chronotherapy  (1)
  • Dexamethasone suppression test  (1)
  • Ehrlich ascites-tumor  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 43 (1981), S. 85-88 
    ISSN: 1432-0584
    Keywords: Lewis lung carcinoma ; Circadian growth rhythm ; Cyclophosphamide ; Chronotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lewis lung carcinoma cells show marked diurnal growth variations with a peak of DNA synthetizing activity between 8.00 and 12.00 p.m. Therapy with cyclophosphamide is most effective at 8.00 a.m. and 8.00 p.m. Preliminary results show that this diurnal rhythm cannot be altered by abolition of the light and dark periods.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Ehrlich ascites-tumor ; Hypercaloric feeding ; Proliferation kinetics of tumor cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Oral feeding of mice with hypercaloric diets inhibited growth of a hyperdiploid Ehrlich ascites tumor significantly and modified proliferation kinetics of tumor cells if feeding started 7 days before tumor transplantation. Furthermore, the tumor take rate was significantly reduced. The 4 hypercaloric diets contained as main energy sources carbohydrates, or unsaturated fatty acids, or saturated fatty acids, or a mixture of these substrates. Inhibition of tumor growth was not observed if hypercaloric feeding started on the same day the tumor transplantation occurred. Tumor bearing animals lived significantly longer compared to controls if they are on a hypercaloric diet with unsaturated fatty acids as main energy source. Survival was not influenced by the time feeding started. That means that partial prevention of cachexia was the main reason for longer survival. Feeding with a diet poor in proteins led in both experimental sets to a statistically not significant shortening of the median survival time compared to controls.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1984), S. 137-146 
    ISSN: 1433-8491
    Keywords: Dexamethasone suppression test ; Psychiatric disorders ; Intervening variables ; Dexamethason-Suppressions-Test ; Psychiatrische Erkrankungen ; intervenierende Variable
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In den letzten Jahren wurde in zahlreichen Publikationen der Dexamethason-Suppressions-Test (DST) als geeignetes Instrument zur Diagnostik endogener Depressionen dargestellt. Eigene Untersuchungen an 333 psychiatrischen Patienten und 121 gesunden Kontrollpersonen sprechen gegen eine differentialdiagnostische Wertigkeit des DST. Diese Aussage wird durch neuere Befunde anderer Arbeitsgruppen gestützt. Diagnoseunabhängige Variable wie Schweregrad der Erkrankung, Gewichtsverlust, Schlafstörungen, situativer Stress, Medikamenten- und Alkohol-Entzug sowie die Pharmakokinetik von Dexamethason scheinen entscheidend das Testergebnis zu beeinflussen.
    Notes: Summary In the past few years there have been numerous publications, which have stressed the value of the Dexamethasone Suppression Test (DST) as a diagnostic marker of endonous depression. Our own studies in 333 psychiatric inpatients and 121 healthy subjects did not reveal a differential diagnostic use for the DST. This result is in good agreement with recent results published in the literature. Our own data demonstrate, however, that intervening variables, such as severity of illness, weight loss, sleep disturbances, situational stress, drug and alcohol withdrawal and the pharmacokinetics of dexamethasone, have an important influence on the DST results, regardless of the diagnostic classification.
    Type of Medium: Electronic Resource
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