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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 418 (2002), S. 826-827 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Understanding the role of clouds is one of the major obstacles to successfully modelling Earth's climate. Clouds in the troposphere, the lowest region of Earth's atmosphere, contain water droplets and ice particles ranging in diameter from a few micrometres to tens of millimetres. In Physical ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 55 (1982), S. 301-308 
    ISSN: 1435-1463
    Keywords: Tetrahydrobiopterin ; Parkinson's disease ; endogenous depression ; dopamine ; serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary One patient with agitated, 2 patients with inhibited endogenous depression, and 2 patients with Parkinson's disease were treated with tetrahydrobiopterin (BH4) in single oral doses of 0.9–1 g. Part of the clinical symptoms disappeared in the 2 patients with inhibited endogenous depression after 4–5 hours and the symptoms reappeared approximately 10 hours after the loading. In these two patients urinary free dopamine and serotonin increased from low to high normal values parallel to the clinical improvement. Both patients with Parkinson's disease lost their hypokinesia and rigidity and part of the tremor 4 hours after BH4 for a period of approximately 5 hours. These observations support the theories that depression may be related to a relative lack of certain biogenic amine neurotransmitters and that Parkinson's disease is primarily related to the loss of dopamine neurons. Furthermore, the potential causal role of altered BH4 metabolism in certain cases of depression and Parkinson's disease should be considered. The administration of BH4 may also be of diagnostic importance in diseases related to altered biogenic amine metabolism.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1436-5073
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Der Aufschluß mit Lithiummetaborat wurde zur Auflösung und nachfolgenden AAS von Zn, Sr, Ba, Pb, Co, Cu und Cr in U. S. Geological Survey-Standards G-2 und BCR-1 sowie in Soil-5-Standard der IAEA verwendet. Flammenzerstäubung wurde für Zn und Sr, elektrothermische Zerstäubung für die anderen Elemente verwendet. Die Abweichung der gemessenen Werte von den erwarteten war geringer als 7%. Die rel. Standardabweichung für 5 Wiederholungen war geringer als 17%. Die gleiche Probelösung kann zur Bestimmung der Hauptbestandteile verwendet werden.
    Notes: Summary The lithium metaborate flux-fusion sample preparation was used for dissolution and subsequent atomic absorption determination of Zn, Sr, Ba, Pb, Co, Cu and Cr in the U. S. Geological Survey standards G-2 and BCR-1 and in the Soil-5 standard from the International Atomic Energy Agency. Flame atomization was used for Zn and Sr and electrothermal atomization for the other elements. The deviations of the measured values from the expected ones were less than 7%. The relative standard deviations for 5 replicates were bellow 17%. The same sample solution can be used for the determination of the major constituents.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1436-5073
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung In salzreichen Wässern enthaltenes Barium wird von störenden Ionen durch Ionen-Austausch-Chromatographie über Dowex 50 W-X8 getrennt und mit 0,1M EDTA ausgewaschen. Mineralwässer mit geringem Salzge- halt werden unmittelbar in den Ofen eingebracht und die Standard-Zugabe- Methode angewendet. Die Nachweisgrenze liegt bei 90pg/10νl. Die Methode wurde zur Untersuchung von Proben aus dem Atlantischen Ozean sowie aus dem Araruama-See angewendet. Außerdem wurde Barium in handelsüblichen Trinkwässern bestimmt.
    Notes: Summary A simple method for the determination of barium in natural waters by flameless atomic absorption spectrometry using the carbon rod is proposed. Barium in highly salted waters is previously separated from the interfering ions by ion-exchange chromatography, using Dowex 50 W-X8 resin, and eluted with 0.1M EDTA solution. Mineral waters with low salinity are transferred directly to the furnace and the standard addition method is performed. The detection limit is 90 pg Ba for 10νl injections. The method was applied to samples from the Atlantic Ocean and from Araruama Lake. Barium in commercially available waters was also determined.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1076
    Keywords: Atypical phenylketonuria ; Dihydropteridine reductase deficiency ; Hyperphenylalaninemia ; Screening ; Tetrahydrobiopterin ; Therapy ; Biopterin ; Neopterin ; Sepiapterin ; Phenylalanine ; Serotonin ; Metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Administration of a single dose of tetrahydrobiopterin dihydrochloride, 10–20 mg/kg orally, to a patient with dihydrobiopterin deficiency led to disappearance of clinical symptoms for 4 days, normalization of urinary phenylalanine and serotonin and decrease of elevated neopterin for 2–3 days. A dose-dependent stimulation of serotonin production was observed. A similar effect was note with even lower doses of L-sepiapterin. The patient is now under monotherapy with tetrahydrobiopterin·2 HCl, 2.5 mg/kg daily. Other patients with this disease may not respond as well. Results of screening for tetrahydrobiopterin deficiency in 228 cases with hyperphenylalaninemia, including 140 newborns, are reported. There is evidence that biopterin biosynthesis in human kidney and liver proceeds via a dioxo compound and L-sepiapterin.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 71 (1984), S. 321-322 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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