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  • 2000-2004  (1)
  • 1980-1984  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Heat shock effects on cell cycle progression (2000)
    Springer
    Cellular and molecular life sciences 57 (2000), S. 450-463 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Heat shock; cell cycle; arrest; cell death; thermotolerance; cyclin-dependent protein kinases.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. In mammalian cells, short-term (acute) exposure to a moderate heat shock leads to a transient arrest of cells at mainly two cell cycle checkpoints, the G1/S and G2/M transitions. This is documented by the more or less synchronous resumption of cell cycle progression from these checkpoints during recovery. The reason for the accumulation of cells at these checkpoints may be found in activity thresholds of cyclin-dependent kinases (Cdks) at both transitions which are determined by (i) the amounts of the responsible cyclins, (ii) regulatory phosphorylation of the Cdks and (iii) the inhibition of Cdks by associated regulatory proteins (Ckis). All three regulatory systems may be subject to heat-shock-dependent changes, the amounts of Ckis, in particular, being increased. Cdk-dependent phosphorylation of the retinoblastoma protein and the subsequent release of active S-phase-specific transcription factors E2F/DP are considered as major heat-sensitive steps in cell cycle progression. Furthermore, high acute heat shock and long-term (chronic) heat treatment may lead to cell-type-specific forms of cell death. All types of responses to heat treatment are subject to adaptation after a ‘priming’ treatment, probably due to higher levels of heat shock proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00000707
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of protein synthesis inhibitors on theGonyaulax clock (1980)
    Springer
    Journal of comparative physiology 138 (1980), S. 9-18 
    Details
    ISSN: 1432-136X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Rhythmic cultures ofGonyaulax polyedra Stein (Strain 70) were placed in constant dim light and analyzed for ultrastructural changes over a period of 32 h. Circadian changes were observed in chloroplast shape and distribution within the cell, as measured quantitatively by the percentage of chloroplasts covering the surface area of the cell, the length of the chloroplasts and their penetration into a central area which is occupied by chloroplasts at only one time of day. Chloroplast portions penetrated this area during the entire subjective day but not during the subjective night. Chloroplasts within this region showed expanded interlamellar distances, whereas only slight changes in the interlamellar distances were observed in the other portions (nearer to the periphery of the cell) of the chloroplast. No changes were observed in the intralamellar distances over the course of a day. In addition, circadian rhythms were detected in the percentage of two and three-stacked thylakoid lamellae and in the number of starch granules present in a defined inner and outer region of the cell. Few if any changes could be observed in the measured diameters of the tubular cristae or in the distances between outer and inner membranes of the mitochondria. Exposure to 1 μM cycloheximide for one hour did not immediately affect the ultrastructural parameters measured or other structural features of the cell. However, such pulses phase-shifted the measured rhythms by 8 to 12 h, the amount being dependent on the circadian phase at which the pulses occurred.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688729
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Evidence for cellular circadian rhythms in isolated fluorescent dye-labelled salivary glands of wild type and an arrhythmic mutant ofDrosophila melanogaster (1981)
    Springer
    Journal of comparative physiology 143 (1981), S. 229-235 
    Details
    ISSN: 1432-136X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fluorescence intensity of isolated salivary gland cells of wild-type and arrhythmic (pero)Drosophila melanogaster larvae was measured in constant conditions. The glands were incubated in a medium containing 3.5×10−6M 3,3′-dihexyl-oxacarbocyanine iodide for which cellular concentrations is probably controlled by the membrane potential. In wild-type cells significant rhythmicity of fluorescence intensity was measured over the cytoplasmic as well as the nuclear areas. In pero cells, arrhythmic and rhythmic changes were registered, the latter showing lower amplitudes. We conclude that the decreased amplitude and the lower number of significant cellular rhythms in pero mutants might lead to an apparent arrhythmicity at the behavioural level, i.e. activity and eclosion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00797702
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    Paper (German National Licenses)
    Fulltext
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