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Digitale Medien

Inactivation of p16INK4a in Primary Tumors and Cell Lines of Head and Neck Squamous Cell Carcinoma (2000)

Kim, Ho-Seok ; Chung, Woon-Bok ; Hong, Su-Hyung ; [weitere]

Springer

Molecules and cells 10 (2000), S. 557-565

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ISSN: 0219-1032

Schlagwort(e): DNA Methylation ; Head and Neck Squamous Cell Carcinoma ; p16INK4a

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract Inactivation of the p16INK4a gene by mutation and deletion is common in head and neck squamous cell carcinoma (HNSCC). The present study demonstrates that hypermethylation of the 5′ CpG islands can serve as an alternative mechanism for the inactivation of the p16INK4a gene in this tumor. We studied 11 HNSCC cell lines and 17 oral squamous cell carcinoma (OSCC) primary tumors for p16INK4a gene status by protein/mRNA and DNA genetic/epigenetic analyses to determine the incidence of its inactivation. Our study indicates that: (1) inactivation of p16 protein is frequent in HNSCC cell lines (6/11, 54.5%) and OSCC primary tumors (15/17, 88.2%), (2) inactivation of p16INK4a protein is commonly associated with the presence of gene alteration such as mutation, homozygous deletion and especially aberrant methylation, and (3) genomic sequencing of bisulfite-modified DNA shows that the carcinoma develops a heterogeneous pattern of hypermethylation.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s10059-000-0557-8

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Digitale Medien

Identification of an atypical constitutent of a clandestine opiate (1974)

Herman, Gary J. ; Kan, Man-Na N.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 1 (1974), S. 350-351

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: An unusual morphine analog was extracted and separated from an opium-like sample. The high resolution mass spectrum of the unknown substance confirmed the empirical formula as C17H18O2NCl. Mass spectra and retention factor values in thin-layer chromatography of both unknown and authentic standards were compared, which lead to the identification of the unknown as β-chloromorphide.

Zusätzliches Material: 1 Ill.