ISSN:
1615-6102
Keywords:
Anaphase-promoting complex
;
Proteolysis
;
Skpl-cullin-F-box complex
;
Ubiquitin
;
von Hippel-Lindau tumor suppressor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Cullins are a recently identified protein family whose founder member, CUL-1, controls cell proliferation inCaenorhabditis elegans and which is conserved from yeasts to humans. Cullins have been found to be subunits of three different protein complexes: the Skpl-cullin-F-box complex (SCF), the anaphase-promoting complex (APC), and the CUL-2 elongin B/C-pVHL complex (CBCVHL). The SCF and the APC control progression through the cell cycle by mediating ubiquitin-dependent proteolysis of regulatory proteins. The CBCVHL complex has been identified through characterization of one of its subunits, the von Hippel-Lindau tumor suppressor protein (pVHL). The function of CBCVHL is unknown, but recent observations raise the possibility that also this complex is a component of the ubiquitin system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01279896
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