ISSN:
1432-0738
Keywords:
Carbromal
;
2-Brom-2-ethylbutyrylcarbamide
;
2-Brom-2-ethyl-3-hydroxybutyramide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Erythro-2-Brom-2-ethyl-3-hydroxybutyramide has been isolated from the urines of patients with Carbromal intoxications as well as from the urine of rat, mouse and dog treated with either Carbromal or with 2-Brom-2-ethylacetamide. The identification of the excreted and synthetized metabolite was carried out by means of IR, Mass and NMR spectroscopy. Along with the erythro-2-Brom-2-ethyl-3-hydroxybutyramide one other bromine containing compound was isolated after Carbromal application only, its mass spectrum and rel. RF values having the same characteristics as the synthetized erythro-2-Brom-2-ethyl-3-hydroxybutyrylcarbamide. However, the purification of this metabolite so far has not been successful.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00352033
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