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  • 1
    Electronic Resource
    Electronic Resource
    Redox behavior of transition metal ions in zeolites. I. Reversibility of the hydrogen reduction of copper Y zeolites (1975)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 79 (1975), S. 2388-2394 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100589a009
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  • 2
    Electronic Resource
    Electronic Resource
    Advection of passive particles in the Kolmogorov flow (2001)
    Woodbury, NY : American Institute of Physics (AIP)
    Chaos 11 (2001), S. 774-779 
    Details
    ISSN: 1089-7682
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A statistical analysis of the advection of passive particles in a flow governed by driven two-dimensional Navier–Stokes equations (Kolmogorov flow) is presented. Different regimes are studied, all corresponding to a chaotic behavior of the flow. The diffusion is found to be strongly asymmetric with a very weak transport perpendicular to the forcing direction. The trajectories of the particles are characterized by the presence of traps and flights. The trapping time distributions show algebraic decrease, and strong anomalous diffusion is observed in transient phases. Different regimes lead to different types of diffusion, i.e., no universal behavior of diffusion is observed, and both time and space properties are needed to define anomalous transport. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1406538
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  • 3
    Electronic Resource
    Electronic Resource
    Formation and destruction of cube texture in MgO films using ion beam assisted pulsed laser deposition (2001)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 90 (2001), S. 1035-1039 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Biaxially textured MgO thin films were deposited on amorphous substrates using ion beam assisted pulsed laser deposition. The development of the texture and microstructure was investigated with electron diffraction and atomic force microscopy. After the first few nanometers of growth, a sharp nucleation texture is observed. During further growth a texture change takes place, leading to two texture components, one in the 〈220〉 direction and the other in the 〈111〉 direction parallel to the substrate normal. In both cases the 〈200〉 direction is parallel to the ion beam. This texture change can be explained in terms of the highly anisotropic sputter rate observed in experiments on single crystals, leading to grains having a 〈200〉 direction parallel to the ion beam during growth being preferred. Without ion beam assistance during further growth, one of the two texture components dominates. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1379558
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  • 4
    Electronic Resource
    Electronic Resource
    AMINO ACID CONCENTRATIONS IN THE APLYSIA NERVOUS SYSTEM: NEURONS WITH HIGH GLYCINE CONCENTRATIONS (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 28 (1977), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The levels of the amino acids glycine, aspartic acid and glutamic acid were determined in the ganglia and in identified neurons of A. californica. All of the determinations were done by gas chromatography–mass spectrometry–selected ion monitoring using deuterium-labelled amino acids as internal standards. Aspartate and glutamate concentrations vary 2- to 3-fold among the ganglia and individual neurons. Glycine levels are 3–10 times higher in the abdominal ganglion than in the other ganglia. This is in large part due to the glycine concentrations in the abdominal ganglion neurons R3–R14 being about 20 times higher than in the somata of most other Aplysia neurons. The concentrations of all three amino acids are several times lower in the muscle than in ganglia, and orders of magnitude lower in the hemolymph than in tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1977.tb10666.x
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  • 5
    Electronic Resource
    Electronic Resource
    Membrane receptors for oestrogen in the brain (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 87 (2003), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Oestrogen is important for the development of neuroendocrine centres and other neural networks including limbic and motor systems. Later in adulthood, oestrogen regulates the functional performance of different neural systems and is presumably implicated in the modulation of cognitive efficiency. Although still a matter of controversial discussion, clinical and experimental studies point at a potential neuroprotective role of oestrogen. Concerning the concept of cellular oestrogen action, it is undisputed that it comprises the binding and activation of nuclear receptors. The last decades have, however, immensely broadened the spectrum of steroid signalling within a cell. Novel steroid-activated intracellular signalling mechanisms were described which are usually termed ‘non-classical’ or ‘non-genomic’. The brain appears to be a rich source of this new mode of oestrogen action. Studies from the past years have pinpointed non-classical oestrogen effects in many CNS regions. All available data support the view that non-classical oestrogen action requires interactions with putative membrane binding sites/receptors. In this article, we aim at compiling the most recent findings on the nature and identity of membrane oestrogen receptors with respect to the brain. We also attempt to turn readers attention to the coupling of these ‘novel’ receptors to distinct intracellular signalling pathways.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2003.02042.x
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  • 6
    Electronic Resource
    Electronic Resource
    Phospholipase D2 modulates agonist-induced µ-opioid receptor desensitization and resensitization (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 88 (2004), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Receptor phosphorylation, arrestin binding, uncoupling from G protein and subsequent endocytosis have been implicated in G protein-coupled receptor desensitization after chronic agonist exposure. In search of proteins regulating the µ-opioid receptor endocytosis, we have recently established that activation of phospholipase D (PLD)2 is required for agonist-induced µ-opioid receptor endocytosis. In this study, we determined the effect of PLD2 activity on the desensitization and resensitization rate of the µ-opioid receptor. We clearly demonstrated that inhibition of PLD2-mediated phosphatidic acid formation by alcohol (1-butanol or ethanol) or overexpression of a dominant negative mutant of PLD2 prevented agonist-mediated endocytosis and resulted in a faster desensitization rate of the µ-opioid receptor after chronic (d-Ala2, Me Phe4, Glyol5)enkephalin treatment in human embryonic kidney 293 cells. Moreover, inhibition of PLD2 activity led to an impairment of the resensitization rate of the µ-opioid receptor. In summary, our data strongly suggest that PLD2 is a modulator of agonist-induced endocytosis, desensitization and resensitization of the µ-opioid receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2003.02189.x
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  • 7
    Electronic Resource
    Electronic Resource
    A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 88 (2004), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Apolipoprotein E (apoE) is an important protein involved in lipoprotein clearance and cholesterol redistribution. ApoE is abundantly expressed in astrocytes in the brain and is closely linked to the pathogenesis of Alzheimer's disease (AD). We report here that small molecule ligands that activate either liver X receptors (LXR) or retinoid X receptor (RXR) lead to a dramatic increase in apoE mRNA and protein expression as well as secretion of apoE in a human astrocytoma cell line (CCF-STTG1 cells). Examination of primary mouse astrocytes also revealed significant induction of apoE mRNA, and protein expression and secretion following incubation with LXR/RXR agonists. Moreover, treatment of mice with a specific synthetic LXR agonist T0901317 resulted in up-regulation of apoE mRNA and protein in both hippocampus and cerebral cortex, indicating that apoE expression in brain can be up-regulated by LXR agonists in vivo. Along with a dramatic induction of ABCA1 cholesterol transporter expression, these ligands effectively mediate cholesterol efflux in both CCF-STTG1 cells and mouse astrocytes in the presence or absence of apolipoprotein AI (apoAI). Our studies provide strong evidence that small molecule LXR/RXR agonists can effectively mediate apoE synthesis and secretion as well as cholesterol homeostasis in astrocytes. LXR/RXR agonists may have significant impact on the pathogenesis of multiple neurological diseases, including AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2004.02183.x
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 89 (2004), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The most prevalent single-nucleotide polymorphism (SNP) A118G in the human µ-opioid receptor gene predicts an amino acid change from an asparagine residue to an aspartatic residue in amino acid position 40. This N40D mutation, which has been implicated in the development of opioid addiction, was previously reported to result in an increased β-endorphin binding affinity and a decreased potency of morphine-6-glucuronide. Therefore, in the present study we have investigated whether this mutation might affect the binding affinity, potency, and/or the agonist-induced desensitization, internalization and resensitization of the human µ-opioid receptor stably expressed in human embryonic kidney 293 cells. With the exception of a reduced expression level of N40D compared to human µ-opioid receptor (hMOR) in HEK293 cells, our analyses revealed no marked functional differences between N40D and wild-type receptor. Morphine, morphine-6-glucuronide and β-endorphin revealed similar binding affinities and potencies for both receptors. Both the N40D-variant receptor and hMOR exhibited robust receptor internalization in the presence of the opioid peptide [d-Ala2,N-MePhe4,Glyol5]enkephalin (DAMGO) and β-endorphin but not in response to morphine or morphine-6-glucuronide. After prolonged treatment with morphine, morphine-6-glucuronide or β-endorphin both receptors showed similiar desensitization time courses. In addition, the receptor resensitization rates were nearly identical for both receptor types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2004.02340.x
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  • 9
    Electronic Resource
    Electronic Resource
    Alkylidenediquinocyclopropanes. Synthesis and properties (1977)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 99 (1977), S. 6290-6296 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00461a018
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  • 10
    Electronic Resource
    Electronic Resource
    PbTe based superlattice structures with high thermoelectric efficiency (2002)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 80 (2002), S. 1216-1218 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report on an enhanced thermoelectric figure of merit ZT=σS2T/λ (where σ is electrical conductivity, S is thermopower, T is absolute temperature, and λ is thermal conductivity) for PbTe/PbSe0.20Te0.80 superlattices (SLs) and PbTe doping SLs due to a reduction of the thermal conductivity λ parallel to the layer planes. Despite a small decrease of the power factors σS2 due to a reduction of σ in these superlattices, the figure of merit is higher as compared to the corresponding bulk materials and reaches maximum values in the temperature range between 400 and 570 K.© 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1448388
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