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  • 2000-2004  (2)
  • 1975-1979  (2)
  • Benzodiazepines  (2)
  • Hepatocellular carcinoma  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Portal Vein Thrombosis Caused by Microwave Coagulation Therapy for Hepatocellular Carcinoma: Report of a Case (2000)
    Springer
    Surgery today 30 (2000), S. 844-848 
    Details
    ISSN: 1436-2813
    Keywords: Key Words Portal vein thrombosis ; Microwave coagulation therapy ; Hepatocellular carcinoma ; Fibrinolytic therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Microwave coagulation therapy (MCT) is one of the treatment modalities for patients with hepatocellular carcinoma (HCC). A 67-year-old man with liver cirrhosis underwent MCT during a laparotomy for a deeply located HCC (2.5 cm in diameter) at the border of the anterior and posterior segments of the right hepatic lobe. Two weeks after MCT, he complained of abdominal fullness. Portal vein thrombosis (PVT) was diagnosed because he had massive ascites and an echogenic mass in the portal vein on abdominal ultrasonography. PVT was successfully treated by fibrinolytic therapy with a selective infusion of urokinase via the superior mesenteric artery (SMA). There have been few reports on PVT as a complication of MCT. Attention should be paid to the possible occurrence of PVT as a critical complication after MCT for liver tumors adjacent to the portal vein. Fibrinolytic therapy via the SMA is thus considered to be an effective approach for PVT after MCT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950070071
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Head twitches induced by benzodiazepines and the role of biogenic amines (1976)
    Springer
    Psychopharmacology 49 (1976), S. 259-261 
    Details
    ISSN: 1432-2072
    Keywords: Head twitches ; Benzodiazepines ; Serotonin ; Dopamine ; Norepinephrine ; GABA ; Glycine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clonazepam, one of the benzodiazepines, induced head twitches in mice in a dose-dependent manner and sustained them for at least 120 min. Some of the benzodiazepines such as nitrazepam, fludiazepam, and nimetazepam also significantly induced head twitches at doses higher than 10 mg/kg, but other benzodiazepines like diazepam, flurazepam, oxazepam, medazepam, and chlordiazepoxide did not significantly induce head twitches at doses up to 60 mg/kg. The head twitches induced by clonazepam were more strongly blocked by an antiserotonin drug, cyproheptadine than catecholamine receptor blocking drugs, haloperidol, propranolol, and phentolamine, and were not blocked by GABA receptor blocking drugs, bicuculline and picrotoxin, as well as by a glycine receptor blocking drug, strychnine. Clonazepam also increased the head twitches induced by mescaline, a serotonin receptor stimulant. These results indicate that the head twitches induced by clonazepam might be mediated via serotonergic neuron systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426826
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of benzodiazepines on central serotonergic neuron systems (1977)
    Springer
    Psychopharmacology 53 (1977), S. 121-126 
    Details
    ISSN: 1432-2072
    Keywords: Benzodiazepines ; Serotonin ; Mescaline ; Head twitches ; Muscle relaxation ; Anticonvulsion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intracerebral (i.c.) injection of serotonin (5-HT) into mice induced head twitches in a dose-dependent manner at 10 min after injection. The head twitches induced by 5-HT (i.c.) were potentiated by the pretreatment of isocarboxazid (3 mg/kg i.p.), and inhibited by cyproheptadine (0.3 mg/kg i.p.), a 5-HT antagonist. Benzodiazepines such as fludiazepam and diazepam potentiated the head twitches induced by 5-HT (i.c.) in a dose-dependent manner. Mescaline (50 mg/kg i.p.) also induced head twitches in mice at 15 and 30 min after injection. Benzodiazepines potentiated the head twitches induced by mescaline in a dose-dependent manner. Cyproheptadine blocked the potentiating effect of benzodiazepines on the head twitches induced by both 5-HT (i.c.) and mescaline. By repeated administration of fludiazepam or diazepam for 5 days, the potentiating effect of both drugs on the head twitches induced by mescaline was unchanged and their anticonvulsant effects were not modified. In contrast, the potency of both drugs on muscle relaxation was significantly decreased by repeated administration. Benzodiazepines failed to change the uptake of 5-HT into the synaptosomal fractions from the rat brain. These results suggest that the pharmacological action of benzodiazepines is derived at least in part from their activating effect on 5-HT receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426480
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Identification of novel polymorphisms in the AXIN1 and CDX-2 genes (2000)
    Springer
    Journal of human genetics 45 (2000), S. 254-256 
    Details
    ISSN: 1435-232X
    Keywords: Key words Single nucleotide polymorphism ; Colorectal cancer ; Hepatocellular carcinoma ; Axin ; Cdx-2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Axin and Cdx-2 play important roles in the tumorigenesis of human liver and colon. We have identified seven novel single-nucleotide polymorphisms (SNPs) in the AXIN1 gene and three in the CDX-2 gene. The identification of SNPs in these cancer-associated genes establishes a basis for future investigations to detect losses of heterozygosity in tumors; these SNPs may also provide genetic background information associated with cancer risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380070036
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    Paper (German National Licenses)
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