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  • 2000-2004  (1)
  • 1975-1979  (1)
  • animal models  (1)
  • mouse  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Angiogenesis Assays: Problems and Pitfalls (2000)
    Springer
    Cancer and metastasis reviews 19 (2000), S. 167-172 
    Details
    ISSN: 1573-7233
    Keywords: angiogenesis ; methodology ; animal models ; assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Many studies of angiogenesis inducers and inhibitors rely on in vitro or in vivo models as indicators of efficacy. However, as valuable as these models are, there are limitations to each one of these. This overview describes some of the principal methods now in use and discusses the advantages and some of the limitations of these methods. It is suggested that multiple assays, involving both in vitro and in vivo assays, are at present the best way to minimize the problems inherent in any specific assay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026574416001
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    An acid phosphatase locus expressed in mouse kidney (Apk) and its genetic location on chromosome 10 (1978)
    Springer
    Biochemical genetics 16 (1978), S. 239-245 
    Details
    ISSN: 1573-4927
    Keywords: mouse ; acid phosphatase ; Apk, chromosome 10 ; lysosomal enzymes ; isozymes ; allozymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A genetic locus controlling the electrophoretic mobility of an acid phosphatase in mouse kidney is described. This locus, called acid phosphatase-kidney (Apk), is not expressed in erythrocytes, liver, spleen, heart, lung, brain, skeletal muscle, stomach, or testes. The product of Apk hydrolyzes the substrate naphthol AS-MX phosphoric acid but is not active on a-naphthylphosphate or 4-methylumbelliferylphosphate. It is not inactivated by 50 C for 1 hr, nor is its electrophoretic mobility altered by incubation with neuraminidase. The locus is invariant among 31 inbred strains (Apk a), with a variant allele (Apk m) observed only in Mus musculus molossinus. Codominant expression was observed in F1 hybrids of M. m. molossinus and inbred strains. Apk was mapped on Chr 10, near the neurological mutant waltzer (v).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484081
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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