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  • 2000-2004  (3)
  • 1975-1979  (7)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 17 (1977), S. 341-353 
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 99 (1977), S. 2809-2811 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 100 (1978), S. 6002-6007 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 100 (1978), S. 4746-4749 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    CNS drug reviews 9 (2003), S. 0 
    ISSN: 1527-3458
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: BP 897 is a potent (Ki= 0.92 nM) dopamine D3 receptor compound developed for the treatment of cocaine abuse and craving. BP 897 has a high selectivity for the dopamine D3 versus D2 receptors (70-fold) and a moderate affinity for 5-HT1A receptors, (Ki= 84 nM), adrenergic-α1 (Ki= 60 nM) and -α2 adrenoceptors (Ki= 83 nM). BP 897 displays significant intrinsic activity at the human dopamine D3 receptor by decreasing forskolin-stimulated cAMP levels and by stimulating mitogenesis of dopamine D3-expressing NG108–15 cells. Although these findings suggest that BP 897 is a partial agonist, recent studies in Chinese Hamster Ovary (CHO) cells with expressed dopamine D3 receptors demonstrated that BP 897 is devoid of any intrinsic activity but potently inhibits dopamine agonist effects (pIC50= 9.43 and 9.51) in agonist-induced acidification rate or increase of GTPγS binding, respectively. In addition, BP 897 inhibits in vivo (EC50= 1.1 mg/kg, i.v.) agonist-induced decrease of firing rate of dopaminergic neurons in the substantia nigra.It has been clearly shown that BP 897, 1 mg/kg, i.p., reduces cocaine-seeking behavior in rats, without producing reinforcement on its own. In rhesus monkeys, BP 897 is not self-administered (up to 30 μg/kg, i.v.) but reduces cocaine self-administration. The potential usefulness of BP 897 in the treatment of drug-seeking behavior is further supported by its effects in drug conditioning models. Although BP 897 reduces L-DOPA-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys, it provokes a return of parkinsonian symptoms. At high doses BP 897 has been reported to produce catalepsy in rats. Pharmacokinetic and toxicological data have not yet been published. These interesting preclinical findings with BP 897 provide additional validation for dopamine D3 receptor as a therapeutic target for the treatment of cocaine abuse and its associated central nervous system (CNS) disorders. BP 897 recently entered phase II clinical studies.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract When exposed to oil-contaminated seawater, marine animals accumulate a wide variety of petroleum hydrocarbons in their tissues. Generally, the aromatic hydrocarbons are accumulated to a greater extent and are retained longer than the alkanes. In all species tested, accumulation of aromatic hydrocarbons appears to be dependent primarily on a partitioning of the hydrocarbons between the exposure water and the tissue lipids. Current evidence indicates that binding of hydrocarbons to tissue lipids is by hydrophobic interactions and not by covalent bonding. Bioaccumulation factors (tissue: water concentration ratio) increase in proportion to the increase in molecular weight of the aromatic hydrocarbons. When returned to oil-free seawater, marine animals rapidly release the accumulated hydrocarbons from their tissues. Release rates are species-dependent. Shrimp and fish, which can metabolize aromatic hydrocarbon, release them more rapidly than clams and oysters, which apparently lack the detoxifying enzymes. Release of hydrocarbons to background or undetectable levels requires from 2 to 60 days. The high molecular weight aromatic hydrocarbons are released more slowly than the low molecular weight hydrocarbons.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 32 (1976), S. 498-500 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 35 (2000), S. 3467-3478 
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A new class of braided composites has been designed to maximise thetotal energy absorbed during tensile failure. Braided loops oflight, continuous fiber tows are configured in such a way that theymust be drawn through relatively large displacements before they comeinto direct contact with one another. Upon loop contact, thematerial hardens locally, forcing further damage to develop by thesame process elsewhere. In this way the entire gauge section absorbsenergy before ultimate failure. Levels of energy absorption per unitvolume reach 30 MJ/m3 and, per unit mass, 18 J/g. The mechanismsinvolved in damage delocalisation and failure are detailed andmodeled at a very simple level. While the current values of energyabsorption are already attractive, the simple models indicate muchhigher values for composites that have been optimised.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Social psychiatry and psychiatric epidemiology 35 (2000), S. 353-357 
    ISSN: 1433-9285
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract   Background: Study of the contribution of retrospective perceptions of dysfunctional parenting in relation to adult psychopathology has been greatly facilitated by the development of the 25-item Parental Bonding Instrument (PBI; Parker et al. 1979). Method: The present study employed confirmatory factor analytic techniques to evaluate competing models of the basic dimensions underlying different versions of the PBI, in a psychiatric sample from a mood disorders program and with a new modification of the PBI employed in the US National Comorbidity Survey. Results: The results indicated that a three-factor model originally identified in a 16-item version of the PBI modified for epidemiological research (Kendler 1996) showed the best fit to the data. The three dimensions of care, overprotection, and authoritarianism also explained the underlying structure of the NCS-modified, eight-item PBI that is now part of the NCS public use dataset available to psychopathology researchers. Conclusions: The replicability of findings across gender, age, and clinical versus community samples attests to the robustness of this three-factor structure of parenting styles.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary When a [psi -] strain of yeast mutates to [psi +], the efficiency of suppression by certain ochre suppressors is increased. The [psi +] phenotype is inherited extrachromosomally. There is a nuclear gene, PNM, which, when mutant, causes loss of the [psi +] phenotype. PNM - is dominant to PNM + and a heterozygous diploid gradually loses the ability over successive generations, to produce PNM + [psi +] spores. This paper describes the kinetics of this elimination and the data obtained are discussed in relation to two models of the molecular nature of the [psi] genetic determinant—one considering the [psi] determinant as an autonomous nucleic acid, the other treating the possibility that the [psi] nucleic acid is that which codes for rRNA in the nuclear genome.
    Type of Medium: Electronic Resource
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