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  • 2000-2004  (2)
  • 1975-1979  (11)
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  • 1
    Electronic Resource
    Electronic Resource
    Shape and volume of fragments Fab' and (Fab')2 of anti-poly(D-alanyl) antibodies in the presence and absence of tetra-D-alanine as determined by small-angle x-ray scattering (1975)
    s.l. : American Chemical Society
    Biochemistry 14 (1975), S. 1326-1333 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00677a035
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The Role of Antigenic Structure in B Lymphocyte Activation (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 23 (1975), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-065X.1975.tb00158.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Enzymatic degradation of collagen-guided tissue regeneration membranes by periodontal bacteria (2003)
    Oxford, UK : Munksgaard International Publishers
    Clinical oral implants research 14 (2003), S. 0 
    Details
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Bacterial infection in the vicinity of guided tissue regeneration barrier membranes was shown to have a negative effect on the clinical outcomes of this increasingly used technique. Several oral and specifically periodontal bacteria were shown to adhere to such membranes in vivo and in vitro with a higher affinity to membranes constructed from collagen. The present study examined the role of periodontal bacteria and their enzymes in the degradation of commercially used collagen membranes. Degradation of two collagen membranes [BiomendTM (Calcitek®, Colla-Tec Inc., Plainsboro, NJ) and Bio-GideTM (Geistlich Biomaterials, Wolhousen, Switzerland)] labeled by fluorescein isothiocyanate was examined by measuring soluble fluorescence. Porphyromonas gingivalis, Treponema denticola and Actinobacillus actinomycetemcomitans and their enzymes were evaluated. Collagenase from Clostridium hystolyticum was used as a positive control. While whole cells of P. gingivalis were able to degrade both types of membranes, T. denticola could degrade Bio-Gide membranes only and A. actinomycetemcomitans whole cells could degrade none of the membranes. Fractionation of P. gingivalis cells revealed that cell membrane associated proteases were responsible for the degradation of the two collagen membranes. In T. denticola, the purified major phenylalanine protease was found to be responsible for the degradation of Bio-Gide membranes. These results suggest that proteolytic bacterial enzymes may take part in the degradation of collagen barrier membranes used for guided tissue regeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0501.2003.140302.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Inhibition of tumor growth by poly(ethylene glycol) derivatives of anti-ErbB2 antibodies (2000)
    Springer
    Cancer immunology immunotherapy 49 (2000), S. 226-234 
    Details
    ISSN: 1432-0851
    Keywords: Key words Anti-ErbB2 ; PEG ; Tumor ; Fab′
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Poly(ethylene glycol) (PEG) modification of substances with antitumor activity was shown to enhance penetration into growing solid tumors and extend antitumor effects. Accordingly, PEG was introduced as a modifier to two types of monoclonal antibodies (N12 and L26) specific to the ErbB2 (HER2) oncoprotein. These antibodies suppress the growth of tumors overexpressing ErbB2 (e.g. N87 human tumor) and the effect of PEG on their antitumor activity was evaluated. Methoxy-PEG-maleimide conjugated to sulfhydryl groups at the hinge region of the antibodies impaired their antibody binding to N87 tumor cells and did not enhance the antitumor inhibitory activity in tumor-bearing mice. A branched N-hydroxysuccinimide-activated PEG (PEG2), conjugated through amino groups of the protein, was used for binding to the whole antibody (Ab) or to its monomeric Fab′ fragment. When tested against N87 cells in vitro, the binding activity and antitumor cytotoxic effects of Ab-PEG2 were mostly preserved. PEG2 modification did not seem to alter the tumor-inhibitory activity of the antibodies in vivo and the same pattern of tumor development was observed during the first few weeks following administration. However, the stimulating effects of PEG were observed at later stages of tumor growth since tumor development was either slowed down or completely arrested. Furthermore, a second tumor implanted into the same mice during this later stage was significantly or completely inhibited, as compared to results in mice injected with the unmodified antibody. The Fab′-PEG2 monomeric derivative was also shown to be effective in inhibiting the growth of a second tumor. The extended and prolonged enhancing effect of PEG on the antitumor activity of antibodies or Fab′ fragments directed against ErbB2 may be of importance in the treatment of ErbB2-overexpressing neoplasms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620000112
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The relationship between HLA antigens and Bermuda grass hayfever (1978)
    Springer
    Immunogenetics 7 (1978), S. 259-264 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01844013
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The challenge of the combined use of synthetic antigens and synthetic adjuvants (1979)
    Springer
    Springer seminars in immunopathology 2 (1979), S. 119-132 
    Details
    ISSN: 1432-2196
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201977
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Binding of histamine- and other ligand-conjugated macromolecules to lymphocytes (1975)
    Springer
    Molecular and cellular biochemistry 7 (1975), S. 119-126 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary The presence of histamine receptors on lymphocyte membranes was investigated using conjugates of histamine and macromolecules tritiated or iodinated with I125. Histamine-RSA conjugate binds to lymphocytes and causes patching and capping of the bound conjugate. It was found, however, that free histamine did not inhibit the binding of histamine-rabbit serum albumin to mouse lymphocytes, nor did His-RSA interfere with the binding of free histamine. In addition conjugates between RSA and other small molecules, such as ethylamine, ethanolamine, tyramine and glycine, were found to bind to the same sites on lymphocyte membrane as did His-RSA. Ethylamine-RSA like His-RSA when coupled to Sepharose, was capable of removing antibody producing cells from spleen cells of mice immunized against sheep red blood cells. In addition, when spleen cells from such immunized mice were passed through ethylamine or histamine-RSA-Sepharose and the unbound cells were subsequently injected into X-irradiated mice, a 1.8 fold increase in the immunological response was noted. We conclude that the selective binding to lymphocytes of the various ligand-macromolecular conjugates may be due to some general properties of the cell membrane and not to any specific receptors. Nevertheless, these conjugates can be used as a tool to remove selectively antibody producing cells as well as some regulatory cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01792078
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    The effect of leukocyte hydrolases on bacteria (1975)
    Springer
    Inflammation 1 (1975), S. 41-56 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acid hydrolases of human blood leukocytes are highly lytic toStaph. albus, Staph. aureus, andStrep. faecalis. On the other hand, group A and viridans streptococci, encapsulated staphylococci, a variety of Gramnegative rods, andMyc. smegmatis are highly resistant to lysis by leukocyte extracts. The lytic effect of the leukocyte extracts can be mimicked by an artificial “cocktail” which contains crude trypsin, lysolecithin, phospholipase C, and lysozyme. This enzyme mixture is lytic to certain Gram-negative bacteria and encapsulated staphylococci which are resistant to lysis by leukocyte enzymes. Both the leukocyte lysates and the artificial cocktail are more lytic to bacteria harvested from the logarithmic phase of growth than to older cells.Staph. albus andStrep. faecalis, which are not lysed to any appreciable extent by extracts of rabbit intestines, lymphocytes, and platelets, undergo extensive lysis upon the addition of lysozyme, indicating that these cells contain preparatory prolytic agents which are activated by lysozyme. On the other hand, the lysis ofStaph. aureus by extracts of all these cells is less dependent upon lysozyme, indicating that other non-lysozyme-dependent lytic factors are involved in the lysis of this microorganism by certain tissue extracts. It is suggested that the resistance to lysis by leukocyte enzymes of bacterial cell-wall constituents may contribute to the pathogenesis of chronic sequellae, and that artificial enzyme cocktails be used for in vivo treatment of certain chronic inflammatory processes induced by bacteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00918058
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    The effect of leukocyte hydrolases on bacteria (1975)
    Springer
    Inflammation 1 (1975), S. 57-69 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lysis of14C-labeledStaph. aureus by human blood leukocyte lysates, by extracts of rabbit small intestines and pancreas, and by the “cocktail” of enzymes (containing trypsin, lysolecithin, and lysozyme) is strongly inhibited by anionic polyelectrolytes (e.g., heparin, chondroitin sulfate, liquoid (polyanethole sulfonic acid), and DNA). Most of the lytic agents employed were inhibited by cationic polyelectrolytes (e.g., histone, protamin sulfate and polylysin), as well as by gold thiomalate, normal human serum, synovial fluids obtained from patients with knee-joint trauma, extracts of coffee, tea, and cocoa, Ultracorten- and Dexamethasone. On the other hand, some antiinflammatory agents tested (e.g., indomethacin, aspirin, hydrocortisone acetate and succinate, and prednisolone acetate and tributyl acetate) were not inhibitory. All the cationic polyelectrolytes employed and liquoid were also strong inhibitors of lysozyme. Since mixtures of cationic and anionic polyelectrolytes at equimolar concentrations failed to inhibit bacteriolysis, it is postulated that the balance between charged macromolecular substances, which are likely to accumulate in inflammatory foci, may determine the fate of cellular components of bacteria in inflamed tissues. The possible role played by lysosomal enzymes and by tissue inhibitors in tissue damage and in the survival of bacteria in chronic inflammatory lesions is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00918059
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  • 10
    Electronic Resource
    Electronic Resource
    The effect of leukocyte hydrolases on bacteria (1978)
    Springer
    Inflammation 3 (1978), S. 59-80 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Small amounts of human leukocyte extracts (ENZ), inflammatory exudates, lysozyme (LYZ), and a variety of neutral proteases are capable of releasing (solubilizing) lipopolysaccharides (LPS) fromSalmonella typhi. LPS activity was determined by its capacity to sensitize red blood cells (RBC) passively to agglutination by antisalmonella serum. While the LPS-releasing capacity of ENZ, inflammatory exudates, and trypsin can be inhibited by phenyl-methyl-sulfonyl fluoride (PMSF, a known protease inhibitor), that of papain and LYZ is inhibited by heat treatment. On the other hand, excess amounts of ENZ, inflammatory exudate, and proteases failed to release substantial amounts of active LPS. The failure of large amounts of the releasing agents to yield LPS is due to the presence in the bacterial extracts of inhibitors to LPS which can, however, be removed by treatment with phenol. Thus the full amount of LPS can be recovered. The release of LPS by small amounts of ENZ is strongly inhibited by anionic and cationic polyelectrolytes (heparine, chondroitin sulfate, histone) as well as by normal serum and by antisalmonella serum. The inhibitors for LPS present in serum are not associated with antibodies to LPS but with other still unidentified serum proteins. Excess amounts of inflammatory exudates and anionic and cationic polyelectrolytes are also capable of blocking the receptors for LPS upon the RBC surface. The inhibition can however be overcome by trypsin and by anionic polyelectrolytes. The capacity of LPS to bind to RBC depends upon the state of activation of the LPS molecule and on the availability of unmasked receptor sites. While the activation of the LPS molecule can be achieved by pretreatment with small amounts of ENZ or by NaOH the unmasking of receptor sites upon RBC can be achieved by treatment with small amounts of ENZ or by neutral proteases. LPS released from the bacteria either by phenol or by ENZ can be separated into two fractions by gel filtration on Sephadex G-200. While the bulk of the LPS is associated with a fraction with a molecular weight similar to that of DNA, a smaller fraction which may represent deaggregated LPS has a molecular weight lower than hemoglobin. The role played by anionic and cationic polyelectrolytes by serum proteins and by activators of LPS and of LPS receptors, upon mammalian cells, in the initiation of passive immune cytolysis is discussed in relation to the pathogenesis of tissue damage induced in inflammatory sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00917322
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