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  • 1
    Electronic Resource
    Electronic Resource
    ANTIARRHYTHMIC PROPERTIES OF 5-(3-TERT-BUTYLAMINO-2-HYDROXY)PROPOXY-3,4-DIHYDRO-CARBOSTYRIL HYDROCHLORIDE (OPC- 1085), A NEWLY SYNTHESIZED, POTENT β-ADRENORECEPTOR ANTAGONIST (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 4 (1977), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The antiarrhythmic properties of 5–(3-tert-butylarnino-2-hydroxy)propoxy-3,4-dihydrocarbostyril hydrochloride (OPC-1085) were compared with those of propranolol and pindolol using various kinds of preparations for experimental arrhythmia in dogs.2. Although OPC-1085 was the most potent drug to antagonize adrenaline-induced arrhythmia in animals anaesthetized with either pentobarbitone sodium or halothane, it was scarcely effective on ouabain-induced arrhythmia in pentobarbitone sodium anaesthetized animals.3. When these compounds were administered intravenously to conscious dogs 24 h after two-stage ligation of the anterior descending artery, ectopic ventricular beats of coronary ligation-induced arrhythmia were reduced while regular sinus beats were simultaneously increased.4. OPC-1085 was very effective on aconitine-induced arrhythmia in dogs anaesthetized with pentobarbitone sodium. The effective dose was similar to that of propranolol but about fifteen times less than that of pindolol.5. It is concluded that different potencies among these β-adrenoreceptor antagonists against various kinds of experimental arrhythmias cannot be simply deduced from any one of the following properties; β-adrenoreceptor antagonism, intrinsic myocardial stimulation, local anaesthetic and so-called quinidine-like effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1977.tb02684.x
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  • 2
    Electronic Resource
    Electronic Resource
    Tooth contacts at the mandibular retruded position, influence of operator's skill on bite registration (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 30 (2003), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary  Occlusal conditions at the retruded contact position (RCP) have been thought to be among the aetiological factors for temporomandibular disorders. However, the role of these occlusal factors still remain unclear. The purpose of a series of studies was to investigate the locations of RCP contacts and to discuss their implication by the authors. In the study reported here, the influence of the operator's skill on bite registration was surveyed. Eighty-six dental students were selected as subjects. One specialist in prosthetic dentistry moved the subject's mandible up and down while guiding it gently backward until it rotated on its retruded axis. Once the initial tooth contacts were established, the operator checked them by using a thin articulating paper (direct method). On the other hand, six younger operators following precise instruction from the specialist about the technique of jaw guidance examined each of the subjects for location of RCP contacts using the indirect method. Silicone-based impression material was used for bite registration while the subject kept the jaw at this contact position (indirect method). Wilcoxon signed rank test was applied to evaluate differences between the expert operator and six younger operators regarding locations of RCP contacts. Results from the expert operator (direct method) showed that tooth contact at the first premolar was most frequently observed and the number of subjects who possessed unilateral tooth contacts was more than that with bilateral tooth contacts. On the other hand, in the case of the indirect method performed by younger operators, tooth contact patterns significantly differed from those of the direct method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2842.2003.01045.x
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  • 3
    Electronic Resource
    Electronic Resource
    Relationship between oral function and occlusal support in denture wearers (2000)
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 27 (2000), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Patients with removable partial dentures or complete dentures do not demonstrate masticatory function to the same level as patients with a full set of natural teeth. The purpose of this study was to characterize the relationship between reduction of masticatory function, in terms of masticatory performance and bite force, and the existence of remaining natural occlusal supports as assessed by the Eichner index. One hundred and eighteen removable partial denture and complete denture wearers were selected for analyses. These subjects were divided into four groups depending upon the number of occlusal supports. Seventy dentate subjects with full occlusal support were designated as a comparison group. Bilateral bite force was measured at the first molar region in all subjects. Masticatory performance was assessed using the modified Masticatory Performance Index. Peanuts were used as the test food. Both bite force and masticatory performance were significantly associated with group classification. Moreover, both bite force and masticatory performance of the four denture groups were significantly reduced compared to the comparison group and this tendency was remarkable for the denture groups without occlusal support. These results suggest that the existence of functional tooth units may be a key factor in preservation of masticatory function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.2000.00602.x
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of nocturnal bruxism on the stomatognathic system. Part I: a new device for measuring mandibular movements during sleep (2001)
    Oxford UK : Blackwell Science Ltd
    Journal of oral rehabilitation 28 (2001), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to investigate the influence of bruxism on the stomatognathic system. A new device for measuring nocturnal mandibular movements was developed using a PIN photodiode sensor, integrated with polysomnography including electromyography (EMG), electroencephalography (EEG) and electro oculography (EOG). One bruxing event was defined depending upon EMG activities above 5% maximum voluntary contraction (MVC), and mandibular movement for each event was classified into three patterns (clenching, grinding and mix). Three subjects were selected for this study. Two of these reported a bruxing habit and one subject had some symptoms of temporomandibular dysfunction (TMD). Mandibular movement was analysed for these subjects. Frequency and duration of the bruxism events were 4·5–10·9 and 47·8–174·9 s h–1 respectively. Clenching type bruxism was most frequently observed for all three subjects and EMG activities during clenching were stronger than grinding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.2001.00757.x
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  • 5
    Electronic Resource
    Electronic Resource
    Mandibular positions and jaw-closing muscle activity during sleep (2000)
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 27 (2000), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to clarify the relationship between the mandibular position with tooth contacts and jaw-closing muscle activity during sleep using electromyography and newly devised equipment for detecting tooth contacts and also to confirm the validity of this system. Five males volunteered for this study and three of them reported their bruxing during sleep. Occurrences of tooth contacts at eccentric mandibular positions in addition to the intercuspal position during sleep were detected using micro photo sensors and sensor targets prepared for the individuals. Electromyographic activities (EMG) from right and left masseter and anterior tempolar muscles were also recorded. Results of the polygraphic recordings demonstrated that the mandibular positions during bruxism could be distinguished clearly whether it's in the right or left position, or has no lateral deviation, and further, that bruxing events could be categorized based on mandibular position pattern. The relationship between the mandibular position and muscle activity could be evaluated using this system. The study suggested the validity of the system for measuring nocturnal bruxing events.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2842.2000.00550.x
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  • 6
    Electronic Resource
    Electronic Resource
    Tooth contacts at the mandibular retruded position, comparison of two different methods for bite registration (2002)
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 29 (2002), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Occlusal conditions at the retruded contact position (RCP) have been thought to be among the aetiological factors for temporomandibular disorders. However, the role of these occlusal factors remains still unclear. The purpose of this series of studies was to investigate the locations of RCP contacts and to discuss their meaning. In this part of the study, two different methods for bite registration at the RCP have been compared. Twenty dentists were selected as subjects for this study. One expert operator moved the subject's mandible up and down while guiding it gently backward until rotating on its retruded axis. Once the initial tooth contacts were established, the operator checked them using a thin articulating paper (direct method). Silicone-based impression material was used for bite registration while the subject kept the jaw at this contact position (indirect method). Differences between the two registration methods regarding locations of tooth contacts were evaluated. Results from the direct method showed that tooth contact at the first premolar was most frequently observed. Statistical difference was not shown between the two registration methods regarding locations of RCP contacts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2842.2002.00917.x
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  • 7
    Electronic Resource
    Electronic Resource
    Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase (2002)
    [s.l.] : Nature Publishing Group
    Nature medicine 8 (2002), S. 1288-1295 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Adiponectin (Ad) is a hormone secreted by adipocytes that regulates energy homeostasis and glucose and lipid metabolism. However, the signaling pathways that mediate the metabolic effects of Ad remain poorly identified. Here we show that phosphorylation and activation of the 5′-AMP-activated ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm788
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of electrostatic field on the diffraction contrast of imperfections in quartz (1975)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 8 (1975), S. 623-627 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: AT-cut oscillator plates were examined by X-ray diffraction topography under an applied electrostatic field of more than 5 kV/mm. Growth layers, cellular structures and some misfit boundaries, which are hardly observable without the field, can be detected with remarkable contrast. After the field has been switched off, the effects decrease with a relaxation time of about 10 h. Not only the converse piezo-electric effect due to an instantaneous field, but also ionic or electronic charges account for the contrast change. The present technique is useful for studying crystal imperfections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889875011508
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  • 9
    Electronic Resource
    Electronic Resource
    Aciculin and its relation to dystrophin: immunocytochemical studies in human normal and Duchenne dystrophy quadriceps muscles (2000)
    Springer
    Acta neuropathologica 99 (2000), S. 654-662 
    Details
    ISSN: 1432-0533
    Keywords: Key words Aciculin ; Dystrophin ; Binding site ; Normal and dystrophic muscles ; Ultrastructural ¶localization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aciculin is a novel adherens junction antigen extracted from human uterine smooth muscle that is reported to associate biochemically with dystrophin. We attempted to determine (i) the immunostainability of anti-aciculin antibody for the 6 histochemically normal human muscles and seven muscles from boys with Duchenne muscular dystrophy(DMD) and 11 disease control muscles, (ii) the ultrastructural localization of aciculin in normal skeletal myofibers, (iii) aciculin’s spacial relationship with dystrophin and β-spectrin, and (iv) if the aciculin is ultrastructurally colocalized with dystrophin, the distance from the aciculin epitope to the epitope of the dystrophin N- or C-terminal domain. For this, rabbit anti-aciculin antibody was generated against the synthetic peptide of aciculin fragment D [4]. Immunohistochemical staining showed that the immunostainability of DMD muscles for anti-aciculin antibody was markedly decreased as compared with normal and disease control muscles. Single and double immunogold labeling electron microscopy of 6 histochemically normal human quadriceps femoris muscles revealed that aciculin was present along the inner surface of muscle plasma membrane and that aciculin formed doublets more frequently with dystrophin (23.5 ± 1.8%; group mean ± SE) than with β-spectrin (12.8 ± 1.1%; P 〈 0.01 two tailed t test). Rabbit anti-aciculin antibody frequently formed doublets with monoclonal antibodies against the N- or C-terminal domain of dystrophin at the muscle cell surface. These results suggest that aciculin is associated with dystrophin and may interact with both the N- and C-terminal domains of dystrophin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051176
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  • 10
    Electronic Resource
    Electronic Resource
    Antimicrobial activity of metal derivatives of sulfonamides (1978)
    Springer
    Cellular and molecular life sciences 34 (1978), S. 472-473 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Antimicrobial activities of a series of metal derivatives of some sulfa drugs were examined. Such metal derivatives showed higher antimicrobial activity than the parent sulfa drugs, and among the metals, gold derivatives are seen to be the most effective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01935934
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