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  • 2000-2004  (2)
  • 1970-1974  (1)
  • 1955-1959  (5)
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  • 1
    Electronic Resource
    Electronic Resource
    Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background The cysteinyl leukotrienes (CysLT) are lipid mediators that have been implicated in the pathogenesis of allergic diseases. Pharmacological studies using CysLTs indicate that two classes of receptors, named CysLT1 and CysLT2 receptor, exist. The former is sensitive to the CysLT1 antagonist currently used to treat asthma and allergic rhinitis. Recently, the cDNA for human CysLT1 and CysLT2 receptor have been cloned, making it now possible to study the gene expression of CysLTs receptors.Objective We have used reverse transcription and polymerase chain reaction (RT-PCR) to study the gene expression of CysLT1 and CysLT2 receptor and in situ hybridization to determine the distribution of CysLT1 receptor mRNA in human nasal mucosa. In addition, the distribution of the CysLT1 receptor protein was studied by immunohistochemistry.Methods Human turbinates were obtained after turbinectomy from six patients with nasal obstruction refractory to medical therapy. Total RNA was isolated from human nasal mucosa and both CysLT1 and CysLT2 receptor mRNA was detected in these tissues by using RT-PCR. For in situ hybridization study of human nasal mucosa, we used biotin-labelled oligonucleotides probes encoding human CysLT1 receptor cDNA. To identify the cells expressing the CysLT1 receptor protein, double immunostaining was performed by using anti-CysLT1 receptor antibody and monoclonal antileucocyte antibodies.Results RT-PCR analysis of total nasal RNA demonstrated the expression of both CysLT1 receptor and CysLT2 receptor mRNA. In situ hybridization indicated high levels of CysLT1 receptor hybridization in blood vessels and the interstitial cells, but a sparse signal in airway epithelium and submucosal glands. The immunohistochemical studies revealed that anti-CysLT1 receptor antibody labelled eosinophils, mast cells, macrophages, neutrophils and vascular endothelial cells in the nasal mucosa.Conclusion The results may have an important clinical implication and also promote further investigation of the regulation of CysLT1 receptor in health and disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2002.01425.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of glucocorticosteroids on tumour necrosis factor-α-induced intercellular adhesion molecule-1 expression in cultured primary human nasal epithelial cells (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective In order to confirm the direct effect of glucocorticosteroids on epithelial intercellular adhesion molecule-1 (ICAM-1) expression, we examined ICAM-1 expression on primary cultured human nasal epithelial cells (HNECs) at both protein and mRNA levels.Material and methods HNECs were stimulated with recombinant human TNF-α (20 pg/mL–20 ng/mL) for specified time periods (0, 12, 24, and 48 h) and ICAM-1 mRNA and the soluble ICAM-1 (sICAM-1) concentrations were measured by quantitative RT-PCR and ELISA, respectively. We also evaluated surface expression of ICAM-1 by flow cytometry 48 h after stimulation and determined the effect of dexamethasone (DEX) on TNF-α-induced ICAM-1 expression.Results Significant increases in ICAM-1 gene expression in HNECs were initially detected at 24 h, peaking at 48 h after the stimulation. The TNF-mediated-ICAM-1 mRNA and ICAM-1 surface expression at 48 h was significantly inhibited by co-incubation with human recombinant soluble TNF receptor I. Similarly, TNF-α-induced release sICAM-1 occurred in a time- and concentration-dependent manner. DEX 10−6 m attenuated the TNF-α-induced ICAM-1 expression at mRNA and protein levels.Conclusions Our finding suggests a potential role for topical steroids in allergic rhinitis in suppressing inflammatory reactions in the nasal mucosa by regulating ICAM-1 expression on nasal epithelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2004.01964.x
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of hydrostatic pressure on CdxHg1−xTe alloys (1973)
    Springer
    Applied physics 2 (1973), S. 151-156 
    Details
    ISSN: 1432-0630
    Keywords: Pressure effects ; CdxHg1−xTe-phase transition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The hydrostatic pressure effects on CdxHg1−xTe alloys have been investigated. In the relatively low pressure region, we find an anomaly in each Hall coefficient vs. pressure curve for the alloys (x〈0.09), which is attributed to the inversion of the Γ8/Γ6 energy bands. In the relatively high pressure region, the electrical resistivities of the alloy crystals (x〉0.09) show changes of three stages with increase of pressure. The crystal structures corresponding to the three stages are studied by an X-ray diffraction analysis. It is found that the crystal structure of the alloys exhibits transitions from the zinc-blende to the rock salt type and at last to the hexagonal cinnabar type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00883977
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  • 4
    Electronic Resource
    Electronic Resource
    Infrared spectrum of polyvinylidene chloride. II (1959)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Polymer Science 37 (1959), S. 263-271 
    Details
    ISSN: 0022-3832
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: In order to complete the more advanced assignments of the bands in the spectrum of polyvinylidene chloride, we prepared deuterated polyvinylidene chloride and obtained its spectrum. With the assumption that frequencies of the skeletal stretching modes and the CCl2-stretching modes cannot change drastically by deuteration, we have achieved the following assignments. Since the frequencies of the bands at 516, 527, 565, 580, 600, and 655 cm.-1 did not change largely by deuteration, they are assigned to the CCl2-stretching modes. We can assign the crystallization sensitive band at 753 cm.-1 to the CH2-rocking mode, because it was shifted to 607 cm.-1 by deuteration. The other crystallization sensitive band at 884 cm. -1, which was shifted to 822 cm.-1 by deuteration, is assigned to the skeletal stretching mode. From the frequency changes by deuteration, we could conclude that our previously reported assignments of the bands at 1046, 1071, 1357, 1407, 2966, and 3010 cm. -1 are reasonable.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1959.1203713120
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  • 5
    Electronic Resource
    Electronic Resource
    Infrared spectrum of polyvinyl chloride. I (1959)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Polymer Science 37 (1959), S. 273-280 
    Details
    ISSN: 0022-3832
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: In order to assign the infrared spectrum of polyvinyl chloride, we obtained the polarized infrared spectra of polyvinyl chloride, the spectral changes of the molten sample, and the infrared spectrum of polyvinyl bromide. The polarized infrared spectra of polyvinyl chloride which we had obtained showed satisfactory agreement with previous reports. The infrared spectra of polyvinyl chloride and polyvinyl bromide resembled each other. From the frequency defferences of the corresponding bands of both polymers, we assigned the bands at 690, 635, and 615 cm.-1 to the C—Cl-stretching modes in the spectrum of polyvinyl chloride. We found four bands in the CH- and CH2-stretching region of polyvinyl chloride as Krimm and Liang stated in their paper.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1959.1203713121
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  • 6
    Electronic Resource
    Electronic Resource
    Infrared spectrum of polyvinyl chloride. II (1959)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Polymer Science 37 (1959), S. 281-294 
    Details
    ISSN: 0022-3832
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: In order to assign the CH, CH2-vibration modes and the skeletal modes in the spectrum of polyvinyl chloride, we obtained deuterated polyvinyl chloride and the infrared spectrum of it, and we assumed that frequencies of the skeletal modes and the C-Cl stretching modes may not change drastically by deuteration. The frequencies of the bands of polyvinyl chloride at 1428, 1333, and 1255 cm.-1 were largely shifted by deuteration and we assign the 1428 cm.-1 band to the CH2-bending mode and the bands at 1333 and 1255 cm.-1 to the CH-deformation modes. As the frequency of the band at 1094 cm.-1 was not largely shifted, we assign it to the skeletal stretching mode. As the band at 969 cm.-1 separated into two components at 937 and 787 cm.-1 by deuteration, we believe that this band consists of two overlapped bands, one caused by the skeletal stretching mode and the other by the CH2-rocking mode. Both the band of polyvinyl chloride at 837 cm.-1 and the band of the deuterated polymer at 806 cm.-1 disappear when they are molten. We think these two bands correspond to each other and assigned them to the skeletal stretching modes.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1959.1203713122
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  • 7
    Electronic Resource
    Electronic Resource
    Infrared spectrum of polyvinylidene chloride. I (1959)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Polymer Science 37 (1959), S. 251-261 
    Details
    ISSN: 0022-3832
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: In order to assign the infrared spectrum of polyvinylidene chloride, we studied the properties of the bands in the spectrum of this polymer and the spectrum of polyvinylidene bromide. We found that many bands disappeared or became weak in the region of 400 to 700 cm.-1, when polyvinylidene chloride was molten. From the relation between the absorption intesities and the density of the polymer, we could prove that the two bands at 753 and 884 cm.-1 are crystallization-sensitive bands. The doubt at 1046 and 1071 cm.-1 in the spectrum of polyvinylidene chloride showed an interesting behavior, i.e., one component at 1046 cm.-1 appeared more strongly than the other at 1071 cm.-1 in the spectrum of the unstretched sample, and their intensity relation was inversed by stretching the sample. The infrared spectrum of polyvinylidene bromide resembled very well to the spectrum of polyvinylidene chloride. We assigned several bands in the spectrum of polyvinylidene chloride from their polarizations and spectral regions, i.e., the doublet at 1046 and 1071 cm.-1 is assigned to the skeletal stretching mode, the parallel brand at 1357 cm.-1 to the CH2--wagging mode, the perpendicular band at 1407 cm.-1 to the CH2--bending mode, the band at 2966 cm. -1 to the CH2-symmetric stretching mode, and the band at 3010 cm.-1 to the CH2-antisymmetric stretching mode.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1959.1203713119
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  • 8
    Electronic Resource
    Electronic Resource
    Infrared spectra of vinylidene chloride-vinyl chloride copolymer (1959)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Polymer Science 36 (1959), S. 389-405 
    Details
    ISSN: 0022-3832
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Observation of the infrared spectra of vinylidene chloride and vinyl chloride copolymers permitted clarification of some points which were rather ambiguous from the study of the homopolymers, and gave some information on the bands of the copolymers. In particular, the band at 868 cm.-1, which had been considered to be that of polyvinylidene chloride, was observed only in the copolymer. Depending on the mode of arrangement of vinylidene chloride and vinyl chloride in the copolymer, the CH-deformation frequency appears at 1206, 1245, or 1255 cm.-1. The same behavior was observed with vinylidene chloride-vinyl bromide copolymers. With the copolymer rich in vinylidene chloride, the band at 1206 cm.-1 can be used for determination of vinyl chloride content. In deuterated vinylidene chloride-vinyl chloride copolymer, the CD2-bending frequency due to the —CDCl—CD2—CCl2—sequence appears at 1081 cm.-1.
    Additional Material: 27 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1959.1203613033
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