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  • 2000-2004  (3)
  • 1970-1974  (2)
  • 1925-1929
  • Analytical Chemistry and Spectroscopy  (1)
  • Biochemistry and Biotechnology  (1)
  • GRGDS  (1)
  • Head and Neck Squamous Cell Carcinoma  (1)
  • Lagrange interpolation polynomial  (1)
Materialart
Erscheinungszeitraum
  • 2000-2004  (3)
  • 1970-1974  (2)
  • 1925-1929
  • 1980-1984  (3)
Jahr
Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Annals of the Institute of Statistical Mathematics 52 (2000), S. 557-573 
    ISSN: 1572-9052
    Schlagwort(e): Chebyshev polynomials ; convex combination ; extremal problems for polynomials ; Lagrange interpolation polynomial ; optimal discrimination designs
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract The extrapolation design problem for polynomial regression model on the design space [−1,1] is considered when the degree of the underlying polynomial model is with uncertainty. We investigate compound optimal extrapolation designs with two specific polynomial models, that is those with degrees |m, 2m}. We prove that to extrapolate at a point z, |z| 〉 1, the optimal convex combination of the two optimal extrapolation designs |ξ m * (z), ξ2m * (z)} for each model separately is a compound optimal extrapolation design to extrapolate at z. The results are applied to find the compound optimal discriminating designs for the two polynomial models with degree |m, 2m}, i.e., discriminating models by estimating the highest coefficient in each model. Finally, the relations between the compound optimal extrapolation design problem and certain nonlinear extremal problems for polynomials are worked out. It is shown that the solution of the compound optimal extrapolation design problem can be obtained by maximizing a (weighted) sum of two squared polynomials with degree m and 2m evaluated at the point z, |z| 〉 1, subject to the restriction that the sup-norm of the sum of squared polynomials is bounded.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Biotechnology letters 22 (2000), S. 1553-1556 
    ISSN: 1573-6776
    Schlagwort(e): fibroblast cell ; gel ; GRGDS ; integrin family ; N-isopropylacrylamide
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Abstract High molecular weight N-isopropylacrylamide copolymers with small amounts of acrylic acid (typically 2–5 mol% in feed) were synthesized by free radical polymerization in benzene and then conjugated with adhesion molecules of Gly-Arg-Gly-Asp-Ser (GRGDS) peptides. Aqueous polymer solutions (5, 6, 8 and 10% w/v) in culture medium (pH 7.4, ionic strength; 0.15 M) with 3T3-L1 fibroblast cells were mixed and poured in Millicells, which supported the gel formation without a significant gel induction time at 36 °C (gelation temperature). The initially formed gel was translucent and became more opaque as the temperature increased. The interaction between fibroblast cells and an artificial matrix of GRGDS containing p(NiPAAm-co-AAc) copolymer gel resulted in effective cell attachment, proliferation and growth. This study supported that specific attachment is the result of the interaction between the integrin families on the fibroblast and the RGD sequence on the p(NiPAAm-co-AAc) copolymer gel.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 0219-1032
    Schlagwort(e): DNA Methylation ; Head and Neck Squamous Cell Carcinoma ; p16INK4a
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Inactivation of the p16INK4a gene by mutation and deletion is common in head and neck squamous cell carcinoma (HNSCC). The present study demonstrates that hypermethylation of the 5′ CpG islands can serve as an alternative mechanism for the inactivation of the p16INK4a gene in this tumor. We studied 11 HNSCC cell lines and 17 oral squamous cell carcinoma (OSCC) primary tumors for p16INK4a gene status by protein/mRNA and DNA genetic/epigenetic analyses to determine the incidence of its inactivation. Our study indicates that: (1) inactivation of p16 protein is frequent in HNSCC cell lines (6/11, 54.5%) and OSCC primary tumors (15/17, 88.2%), (2) inactivation of p16INK4a protein is commonly associated with the presence of gene alteration such as mutation, homozygous deletion and especially aberrant methylation, and (3) genomic sequencing of bisulfite-modified DNA shows that the carcinoma develops a heterogeneous pattern of hypermethylation.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 15 (1973), S. 879-888 
    ISSN: 0006-3592
    Schlagwort(e): Chemistry ; Biochemistry and Biotechnology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The steady state, nonlinear diffusion equations which describe reactions in constrained enzyme solutions are of great interest in many biological and engineering applications. As in other types of nonlinear differential equations, exact analytical solutions do not exist except in some simplified cases. In this paper, a general procedure is presented for solving numerically for the substrate concentration profile and effectiveness factor utilizing the transformation method suggested by Na and Na. Design correlations for enzyme solutions constrained within spherical membranes are included. The use of a unique definition of the Thiele Modulus in these charts permits the clear illustration of the effects of substrate concentration and external mass transfer resistances on the overall effectiveness factor for the catalyst particle.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 350-351 
    ISSN: 1052-9306
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: An unusual morphine analog was extracted and separated from an opium-like sample. The high resolution mass spectrum of the unknown substance confirmed the empirical formula as C17H18O2NCl. Mass spectra and retention factor values in thin-layer chromatography of both unknown and authentic standards were compared, which lead to the identification of the unknown as β-chloromorphide.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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