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  • 1
    Electronic Resource
    Electronic Resource
    Demonstration of adenosin 3′,5′-monophosphate dependent protein-phosphokinase in human platelets (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 1114-1115 
    Details
    ISSN: 1432-1440
    Keywords: Platelets ; Cyclic AMP ; Protein-phosphokinases ; Blutplättchen (Mensch) ; c-AMP ; Protein-Phosphokinase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In menschlichen Blutplättchen wurde eine Enzymreaktion gefunden, die die Eigenschaften typischer Proteinkinasen anderer Zellen und Gewebe zeigt: Phosphorylation basischer Proteine (Histon) in Serin- und Threoninresten, Magnesiumabhängigkeit und Stimulation durch Adenosin 3′,5′-monophosphat. Dieses Enzym könnte ein wichtiges Bindeglied zwischen der intracellulären c-AMP-Konzentration und der Plättchen-Funktion darstellen.
    Notes: Summary An enzyme reaction in human platelets is demonstrated which possesses the properties of protein-phosphokinases isolated from other cells: phosphorylation of basic proteins in phosphoserine and -threonine linkages, magnesium dependency and stimulation by adenosine 3′,5′-monophosphate. It is suggested that this enzyme might be responsible for the expression of the cAMP effects on the platelets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486857
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Detection of lymphocytes with increased DNA-Synthesis in the peripheral blood of patients with active chronic hepatitis (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 190-193 
    Details
    ISSN: 1432-1440
    Keywords: Aktivated Lymphocytes ; DNA-Synthesis ; activ chronic hepatitis ; Aktivierte Lymphocyten ; DNS-Synthese ; aktive chronische Hepatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über die erstmalige Beobachtung von „in vivo aktivierten Lymphocyten“ [IVAL] bei aktiver chronischer Hepatitis berichtet. Solche Lymphocyten mit einem erhöhten „Ruhestoffwechsel“ wurden bei 30% unserer Patienten mit dieser Erkrankung beobachtet. Eine Persistenz der Lymphocytenaktivität ist mit einer schlechten Prognose kombiniert. Die Deutung dieser Zellen als Träger der spezifischen Immunität, vergleichbar der Transplantat-Abstoßungs-Reaktion wird diskutiert.
    Notes: Summary The first observation of “in vivo activated lymphocytes” [IVAL] in cases of active chronic hepatitis is reported. Lymphocytes with an elevated metabolism were observed in about 30% of patients with this disease. The persistence of such active lymphocytes was associated with a bad prognosis. The role of these cells as mediators of specific immunity comparable to the graft rejection is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01614396
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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